Patents by Inventor Günter Billen

Günter Billen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of fexofenadine and of intermediates used therein
    Patent number: 10696633
    Abstract: A new process for the preparation of fexofenadine and of related intermediates, which can be used in the preparation of fexofenadine, is provided.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: June 30, 2020
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Hermut Wehlan, Kai Rossen, Guenter Billen
  • PROCESS FOR THE PREPARATION OF FEXOFENADINE AND OF INTERMEDIATES USED THEREIN
    Publication number: 20180297951
    Abstract: A new process for the preparation of fexofenadine and of related intermediates, which can be used in the preparation of fexofenadine, is provided.
    Type: Application
    Filed: October 21, 2016
    Publication date: October 18, 2018
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Hermut WEHLAN, Kai ROSSEN, Guenter BILLEN
  • Crystalline forms of 2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carboxylic acid [ (S)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl ]-amide
    Patent number: 9067918
    Abstract: The present invention relates to polymorphs and hydrates of 2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carboxylic acid [(S)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide, processes for their preparation and their use, in particular in pharmaceutical compositions.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: June 30, 2015
    Assignee: SANOFI
    Inventors: Olaf Ritzeler, Mandy Mohnicke, Guenter Billen, Bruno Baumgartner, Martin Brockelmann, Norbert Nagel
  • Crystalline forms of 2-(2-methylamino-pyrimidin-4-yl)-1H-Indole-5-carboxylic acid [ (S)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino) -ethyl ] -amide
    Publication number: 20140336211
    Abstract: The present invention relates to polymorphs and hydrates of 2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carboxylic acid [(S)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide, processes for their preparation and their use, in particular in pharmaceutical compositions.
    Type: Application
    Filed: December 4, 2012
    Publication date: November 13, 2014
    Inventors: Olaf Ritzeler, Mandy Mohnicke, Guenter Billen, Bruno Baumgartner, Martin Brockelmann, Norbert Nagel
  • Process for the preparation of 6-substituted-1-(2H)-isoquinolinones
    Patent number: 8716481
    Abstract: The present invention relates to a process for making 6-substituted-1-(2H)-isoquinolinone derivatives of formula (I) wherein R1 and n are as described in the specification. The present invention further relates to novel intermediates which are used in the process according to the invention and to processes for preparing such intermediates.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: May 6, 2014
    Assignee: Sanofi
    Inventors: Kai Rossen, Hermut Wehlan, Oliver Plettenburg, Volker Kraft, Guenter Billen, Simon Gessler
  • METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES
    Publication number: 20140005392
    Abstract: This disclosure relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification, and intermediates thereof.
    Type: Application
    Filed: August 29, 2013
    Publication date: January 2, 2014
    Applicant: Sanofi
    Inventors: Joachim GRAESER, Guenter BILLEN, Adolf LINKIES, Tobias METZENTHIN
  • Method for producing 2-(2-aminopyrimidin-4-yl)-1H-indole-5-carboxylic acid derivatives
    Patent number: 8546567
    Abstract: This disclosure relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification, and intermediates thereof.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: October 1, 2013
    Assignee: Sanofi
    Inventors: Joachim Graeser, Guenter Billen, Adolf Linkies, Tobias Metzenthin
  • 3-[4-(PHENYLAMINOOXALYLAMINO)PHENYL]HEX-4-YNOIC ACIDS, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT
    Publication number: 20130172248
    Abstract: The invention relates to 3-[4-(phenylaminooxalylamino)phenyl]hex-4-ynoic acids, and to physiologically compatible salts thereof. The invention relates to compounds of the formula I in which R1, R2, R3 and R4 are each defined as specified, and to physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
    Type: Application
    Filed: January 4, 2013
    Publication date: July 4, 2013
    Inventors: Elisabeth DEFOSSA, Viktoria DIETRICH, Thomas KLABUNDE, Stefanie KEIL, Siegfried STENGELIN, Guido HASCHKE, Andreas HERLING, Johanna KUHLMANN-GOTTKE, Stefan BARTOSCHEK, Simon GESSLER, Angela DUDDA, Guenter BILLEN, Thomas OLPP, Joerg RIEKE-ZAPP
  • Method for the production of 1,4-benzothiepin-1,1-dioxide derivatives
    Patent number: 8461312
    Abstract: The invention relates to a method for producing 1,4-benzothiepin-1,1-dioxide derivatives substituted with benzyl groups.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: June 11, 2013
    Assignee: Sanofi
    Inventors: Guenter Billen, Wendelin Frick, John Patrick Larkin, Guy Lemaitre, Francoise Bendetti, Philippe Boffelli, Jean-Yves Godard, Christian Masson, Veronique Crocq, Sylvaine Lafont, Jos Hulshof
  • METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES
    Publication number: 20120271051
    Abstract: This disclosure relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification, and intermediates thereof.
    Type: Application
    Filed: July 3, 2012
    Publication date: October 25, 2012
    Applicant: SANOFI
    Inventors: Joachim GRAESER, Guenter BILLEN, Adolf LINKIES, Tobias METZENTHIN
  • Substituted 8-aminoalkylthioxanthines, and their use as inhibitors of dipeptidyl peptidase IV
    Patent number: 8236810
    Abstract: The invention 8-aminothioxanthines and the derivatives of formula I wherein the various R groups and substituents are comprised of a number of different (C1-C10)-alkyl, cycloalkyl, aryl, alkene, alkyne, etc. groups and derivatives thereof which are hereinafter more specifically defined for the treatment of metabolic disorders such as type-2 diabetes, hyperglycemia, arteriosclerotic diseases and the like.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: August 7, 2012
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Karl Schoenafinger, Gerhard Jaehne, Elisabeth Defossa, Guenter Billen, Christian Buning, Georg Tschank, Ulrich Werner
  • Method for producing 2-(2-aminopyrimidin-4-yl)-1H-indole-5-carboxylic acid derivatives
    Patent number: 8232395
    Abstract: This invention relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: July 31, 2012
    Assignee: Sanofi
    Inventors: Joachim Graeser, Guenter Billen, Adolf Linkies, Tobias Metzenthin
  • Method for producing enantiomeric form of 2,3-diaminopropionic acid derivatives
    Patent number: 8053590
    Abstract: The invention relates to a method for producing enantiomers form of 2,3-diaminopropionic acid derivatives of formula (I) by asymmetric hydrogenation from compounds of formula (II).
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: November 8, 2011
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Joerg Rieke-Zapp, Guenter Billen
  • METHOD FOR THE PRODUCTION OF 1,4-BENZOTHIEPIN-1,1-DIOXIDE DERIVATIVES
    Publication number: 20110245486
    Abstract: The invention relates to a method for producing 1,4-benzothiepin-1,1-dioxide derivatives substituted with benzyl groups.
    Type: Application
    Filed: April 29, 2009
    Publication date: October 6, 2011
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Guenter Billen, Wendelin Frick, John Patrick Larkin, Guy Lemaitre, Francoise Bendetti, Philippe Boffelli, Jean-Yves Godard, Christian Masson, Veronique Crocq, Sylvaine Lafont, Jos Hulshof
  • PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES
    Publication number: 20110021779
    Abstract: The present invention relates to a process for making 6-substituted-1-(2H)-isoquinolinone derivatives of formula (I) wherein R1 and n are as described in the specification. The present invention further relates to novel intermediates which are used in the process according to the invention and to processes for preparing such intermediates.
    Type: Application
    Filed: June 17, 2010
    Publication date: January 27, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Kai ROSSEN, Hermut WEHLAN, Oliver PLETTENBURG, Volker KRAFT, Guenter BILLEN, Simon GESSLER
  • METHOD FOR PRODUCING ENANTIOMERIC FORM OF 2,3-DIAMINOPROPIONIC ACID DERIVATIVES
    Publication number: 20090203918
    Abstract: The invention relates to a method for producing enantiomers form of 2,3-diaminopropionic acid derivatives of formula (I) by asymmetric hydrogenation from compounds of formula (II).
    Type: Application
    Filed: April 6, 2009
    Publication date: August 13, 2009
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Joerg RIEKE-ZAPP, Guenter BILLEN
  • Process for the preparation of diphenyl azetidinone derivatives
    Patent number: 7563888
    Abstract: The present invention is a process for the preparation of diphenylazetidinone derivatives of the formula (I) or forms thereof comprising the substituents X, R1 and/or R2 as defined herein. More specifically, the invention comprises methods for the preparation of these compounds by cyclization of certain ?-amino carboxamides or ?-amino carboxylic esters. These diphenylazetidinone compounds are useful in the treatment of high blood serum cholesterol levels and the maintenance of the reduced cholesterol levels achieved thereby.
    Type: Grant
    Filed: November 7, 2006
    Date of Patent: July 21, 2009
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Joachim-Heiner Jendralla, Guenter Billen, Wendelin Frick, Bernd Junker, Theodor Andreas Wollman
  • Method for producing enantiomeric form of 2,3-diaminopropionic acid derivatives
    Patent number: 7514578
    Abstract: The invention relates to a method for producing enantiomeris form of 2, 3-diaminopropionic acid derivatives of formula (I) by asymetric hydrogenation from compounds of formula (II).
    Type: Grant
    Filed: January 10, 2007
    Date of Patent: April 7, 2009
    Assignee: sanofi-aventis Deutschland GmbH
    Inventors: Joerg Rieke-Zapp, Guenter Billen
  • Method for producing 1,4-diphenyl azetidinone derivatives
    Patent number: 7488818
    Abstract: The present invention is directed to the preparation of novel compounds useful in the treatment of hyperlipidemia, arteriosclerosis, hypercholesterolemia, and other related metabolic disorders. More specifically, the present invention is a novel process for the preparation of 1,4-diphenylazetidinone derivatives from ?-substituted amino amides which are protected in the presence of silylating agents and at least one cyclization catalyst whose structural formula is represented by one of the general formula: wherein the various R-groups are defined herein.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: February 10, 2009
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Andreas Lindenschmidt, David William Will, Gerhard Jaehne, Theodor Andreas Wollmann, Wendelin Frick, Bernd Junker, David Rigal, Guenter Billen, Heiner Jendralla
  • METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES
    Publication number: 20080214813
    Abstract: This invention relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification.
    Type: Application
    Filed: December 3, 2007
    Publication date: September 4, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Joachim GRAESER, Guenter BILLEN, Adolf LINKIES, Tobias METZENTHIN