Patents by Inventor Günter Fuhr
Günter Fuhr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240027977Abstract: The invention relates to a method implemented in a control system of a machine for processing input values in an overall system with a working level and an evaluation level comprising inputting first input values to the working level and determining first output values; forming first situation data; inputting the first situation data to the evaluation level and determining first evaluations indicating whether the first situation data satisfy predetermined first conditions; influencing the determination of the first output values based on the first evaluations; inputting second input values to the working level and determining second output values, wherein the determination of the second output values is influenced by the first output values; forming second situation data; inputting the second situation data to the evaluation level and determining second evaluations indicating whether the second situation data satisfy predetermined second conditions, the determining of the second evaluations being influenceType: ApplicationFiled: November 19, 2021Publication date: January 25, 2024Inventors: Heiko ZIMMERMANN, GüNTER FUHR, Antonie FUHR
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Publication number: 20220292331Abstract: Provided are methods in a system of at least a second and a third artificial intelligence unit, comprising: inputting first input values to at least one second artificial intelligence unit, and obtaining output values based on the input values from the at least one second artificial intelligence unit; at least temporarily storing situation data, the situation data comprising first input values and/or second output values of the at least one second unit; using the situation data as input values of the third artificial intelligence unit, the third artificial intelligence unit generating third output values in response to the input values; and checking whether the second output values of the at least one second unit satisfy one or more predetermined conditions based on the third output values. Also provided is a system for carrying out such a method.Type: ApplicationFiled: March 9, 2020Publication date: September 15, 2022Applicants: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V., UNIVERSITÄT DES SAARLANDESInventors: Heiko ZIMMERMANN, Günter FUHR, Antonie FUHR
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Publication number: 20220245429Abstract: Provided is a method in a system of at least two artificial intelligence units, comprising inputting input values to at least a first artificial intelligence unit and a second artificial intelligence unit; obtaining first output values of the first artificial intelligence unit; forming one or more modulation functions based on the output values of the first artificial intelligence unit; applying the formed one or more modulation functions to one or more parameters of the second artificial intelligence unit, the one or more parameters influencing the processing of input values and the obtaining of output values in the second artificial intelligence unit; and finally obtaining second output values of the second artificial intelligence unit.Type: ApplicationFiled: March 9, 2020Publication date: August 4, 2022Applicants: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V., UNIVERSITÄT DES SAARLANDESInventors: Heiko ZIMMERMANN, Günter FUHR, Antonie FUHR
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Patent number: 9752814Abstract: The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, including a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooling chamber (1), a first temperature sensor (8-10) for measuring the temperature (T2-T4) in the cooling chamber (1), a second temperature sensor (7) for measuring the temperature (Ti) of the coolant (3) delivered to the cooling chamber (I), and a regulator (11) for regulating the temperature. The regulator (11) is embodied as a multiple regulator which detects several temperatures (T1-T4) as control variables and/or adjusts several heating performances (P1, P2) as manipulated variables. The invention further relates to a corresponding operating method.Type: GrantFiled: October 7, 2013Date of Patent: September 5, 2017Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG, E.V.Inventors: Uwe Schon, Heiko Zimmermann, Guenter Fuhr
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Publication number: 20140033739Abstract: The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, including a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooling chamber (1), a first temperature sensor (8-10) for measuring the temperature (T2-T4) in the cooling chamber (1), a second temperature sensor (7) for measuring the temperature (Ti) of the coolant (3) delivered to the cooling chamber (I), and a regulator (11) for regulating the temperature. The regulator (11) is embodied as a multiple regulator which detects several temperatures (T1-T4) as control variables and/or adjusts several heating performances (P1, P2) as manipulated variables. The invention further relates to a corresponding operating method.Type: ApplicationFiled: October 7, 2013Publication date: February 6, 2014Applicant: Fraunhofer-Gesellschaft Zur Foerderung der angewandten Forschung, e.V.Inventors: Uwe SCHON, Heiko ZIMMERMANN, Guenter FUHR
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Patent number: 8546117Abstract: A method for forming a three-dimensional cell arrangement (1) of biological cells is disclosed, including the steps of preparation of the cell arrangement (1) on a flexible substrate (10) and deformation of the substrate (10), wherein the deformation of the substrate (10) is brought about by an attractive force exerted by the cells (2) on the substrate (10). A substrate (10), is also disclosed, made from a flexible material and including a substrate surface (11) for adhesion of a cell arrangement (1) of biological cells, wherein the substrate surface (11) has a number of force attachment points arranged to exert an attraction force which may be transmitted from the cells to the substrate (10) and the substrate (10) has a flexibility such that the substrate (10) is deformable with the action of the attraction force.Type: GrantFiled: June 6, 2008Date of Patent: October 1, 2013Assignee: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.Inventors: Charli Kruse, Philipp Ciba, Guenter Fuhr
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Patent number: 8283132Abstract: The invention relates to a method for treating a biological cell (1) including a cytoskeleton (3) enveloped by a cell membrane (2). The method includes the following steps: the biological cell (1) and a tool (10) are mutually oriented such that the tool (10) comes into contact with the biological cell (1); the tool (10) and the biological cell (1) are displaced in relation to each other; and a gap is formed in the molecular composite of the cell membrane (2) of the biological cell (1). During the displacement of the tool (10), the cytoskeleton (3) of the biological cell (1) has a state of equilibrium. The invention also relates to a cell manipulator for carrying out the inventive method.Type: GrantFiled: November 2, 2005Date of Patent: October 9, 2012Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forshung e.V.Inventors: Günter Fuhr, Hagen Thielecke
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Patent number: 7984616Abstract: A cryostorage device (100) is described that includes at least one data storage device (200) and at least one sample receptacle device (300) with at least one sample chamber (301, 302, etc.) for the uptake of a suspension sample, the at least one sample chamber (301, 302, etc.) being connected to the data storage device (200) and having a elongated, hollow shape that extends from an inlet end (320) over a predetermined length to an outlet end (330) and being attached to the at least one data storage device (200) in a flexible and movably hanging manner.Type: GrantFiled: April 20, 2005Date of Patent: July 26, 2011Assignee: Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung E.V.Inventors: Günter Fuhr, Heiko Zimmermann
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Patent number: 7892815Abstract: A conditioning device (100) for biological cells includes a support (10), adapted to support at least one biological cell (1) in a supporting zone (11), and a contact device (20), adapted to support at least one conditioning sample (3) and to displace the at least one conditioning sample (3) relative to the support (10) in such a manner that the at least one conditioning sample (3) touches the at least one biological cell (1), the contact device (20) including at least two mechanical supporting elements (21, 22) that can be displaced from various spatial directions towards the support (10). The invention also relates to methods for conditioning, especially imprinting or differentiating biological cells and to uses of the conditioning device.Type: GrantFiled: September 17, 2008Date of Patent: February 22, 2011Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung e.V.Inventors: Guenter Fuhr, Heiko Zimmermann
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Publication number: 20100196946Abstract: A conditioning device (100) for biological cells includes a support (10), adapted to support at least one biological cell (1) in a supporting zone (11), and a contact device (20), adapted to support at least one conditioning sample (3) and to displace the at least one conditioning sample (3) relative to the support (10) in such a manner that the at least one conditioning sample (3) touches the at least one biological cell (1), the contact device (20) including at least two mechanical supporting elements (21, 22) that can be displaced from various spatial directions towards the support (10). The invention also relates to methods for conditioning, especially imprinting or differentiating biological cells and to uses of the conditioning device.Type: ApplicationFiled: September 17, 2008Publication date: August 5, 2010Applicant: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.Inventors: Guenter Fuhr, Heiko Zimmermann
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Publication number: 20100190249Abstract: A method for forming a three-dimensional cell arrangement (1) of biological cells is disclosed, including the steps of preparation of the cell arrangement (1) on a flexible substrate (10) and deformation of the substrate (10), wherein the deformation of the substrate (10) is brought about by an attractive force exerted by the cells (2) on the substrate (10). A substrate (10), is also disclosed, made from a flexible material and including a substrate surface (11) for adhesion of a cell arrangement (1) of biological cells, wherein the substrate surface (11) has a number of force attachment points arranged to exert an attraction force which may be transmitted from the cells to the substrate (10) and the substrate (10) has a flexibility such that the substrate (10) is deformable with the action of the attraction force.Type: ApplicationFiled: June 6, 2008Publication date: July 29, 2010Applicant: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.Inventors: Charli Kruse, Philipp Ciba, Guenter Fuhr
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Patent number: 7634917Abstract: The invention relates to a cryoapparatus for freezing and/or thawing a sample (1), especially in the cryopreservation of a biological sample (1), with a coolable cooling space (3) and with a sample container (10) arranged in the cooling space (3) for temporarily receiving the sample (1) when freezing or thawing the sample (1). It is suggested that the sample container (10) can be tempered separately from the cooling space. Furthermore, the invention includes an associated operating method.Type: GrantFiled: September 30, 2005Date of Patent: December 22, 2009Assignee: Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung E.V.Inventors: Günter Fuhr, Heiko Zimmermann, Young-Joo Oh, Uwe Schön
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Patent number: 7596957Abstract: The invention relates to a device and method for handling a probe, in particular, for treating, examining, inserting or extracting a cryoprobe. According to the invention, said probe is surrounded by an ambient gas, during handling, and an air-conditioning device (33) cools, dries and/or at least partially replaces the ambient gas by a protective gas, in order to prevent deterioration of the probe by the ambient gas during handling.Type: GrantFiled: July 19, 2004Date of Patent: October 6, 2009Assignee: Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung e.V.Inventors: Günter Fuhr, Uwe Schön, Heiko Zimmermann, Young-Joo Oh
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Publication number: 20090226994Abstract: The present invention relates to a method and device for non-intrusively manipulating suspended particles and/or cells and/or viruses, which are supplied to a micro-chamber or to a micro-channel (46) of a substrate, said micro-chamber or micro-channel (46) having at least a bottom wall as well as lateral walls. At least one acoustic wave (41) is applied via at least one acoustic transducer (42, 44) from outside of said substrate to an inner volume of said micro-chamber or micro-channel (46), a frequency of said acoustic wave (41) being selected to generate a standing and/or stationary acoustic wave in said volume. In the present method and device the acoustic wave (41) is applied laterally to said volume. The present device and method allow an efficient coupling of energy into the channels as well as an improved control of standing and/or stationary acoustic wave fields along the channels.Type: ApplicationFiled: July 7, 2005Publication date: September 10, 2009Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V.Inventors: Robert Lemor, Christian Günther, Günter Fuhr, Martin Wiklund, Hans Hertz
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Publication number: 20090148880Abstract: The invention relates to a method for treating a biological cell (1) including a cytoskeleton (3) enveloped by a cell membrane (2). The method includes the following steps: the biological cell (1) and a tool (10) are mutually oriented such that the tool (10) comes into contact with the biological cell (1); the tool (10) and the biological cell (1) are displaced in relation to each other; and a gap is formed in the molecular composite of the cell membrane (2) of the biological cell (1). During the displacement of the tool (10), the cytoskeleton (3) of the biological cell (1) has a state of equilibrium. The invention also relates to a cell manipulator for carrying out the inventive method.Type: ApplicationFiled: November 2, 2005Publication date: June 11, 2009Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.Inventors: Günter Fuhr, Hagen Thielecke
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Patent number: 7458285Abstract: The invention relates to a sample receiving device (100), particularly for the cryoconservation of at least one sample, including a bundle (10) consisting of a plurality of hose-shaped flexible sample chambers (11, 12, . . . ) and a holding device (20) with which the bundle (10) of the sample chambers is joined. The holding device (20) has a plurality of holding frames (21, 22, . . . ) which are arranged in a longitudinal direction of the bundle (10).Type: GrantFiled: June 23, 2004Date of Patent: December 2, 2008Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung e.V.Inventors: Günter Fuhr, Heiko Zimmermann, Thomas Fixemer
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Publication number: 20080064034Abstract: The invention relates to methods for testing substances using multicellular in vitro test systems, in particular systems that resemble organs, and to devices and kits for carrying out said methods.Type: ApplicationFiled: March 2, 2005Publication date: March 13, 2008Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDInventors: Charli Kruse, Günter Fuhr
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Publication number: 20070267419Abstract: The invention relates to a cryoapparatus for freezing and/or thawing a sample (1), especially in the cryopreservation of a biological sample (1), with a coolable cooling space (3) and with a sample container (10) arranged in the cooling space (3) for temporarily receiving the sample (1) when freezing or thawing the sample (1). It is suggested that the sample container (10) can be tempered separately from the cooling space. Furthermore, the invention comprises an associated operating method.Type: ApplicationFiled: September 30, 2005Publication date: November 22, 2007Applicant: Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung e. V.Inventors: Günter Fuhr, Heiko Zimmermann, Young-Joo Oh, Uwe Schön
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Patent number: 7070684Abstract: A microsystem adapted for dielectrophoretic manipulation of particles in a suspension liquid wherein the microsystem has a channel with channel walls and a longitudinal extension. An electrode arrangement is present which has at least one microelectrode on at least one of the channel walls. This acts to generate a field barrier which crosses the channel at least partly. The microelectrode has a band-shape or has a multitude of straight electrode sections connected to each other. The band-shape has a predetermined curvature or the straight electrode sections are arranged with predetermined different angles so that the field barrier has a predetermined curvature relative to the longitudinal extension of the channel.Type: GrantFiled: June 28, 1999Date of Patent: July 4, 2006Assignee: Evotec Technologies GmbHInventors: Günter Fuhr, Thomas Schnelle, Rolf Hagedorn, Torsten Müller
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Patent number: 6991906Abstract: To measure or exert optically-induced forces on at least one particle in the focus of an optical cage, the following steps are taken: a) the focus is positioned in a microelectrode arrangement with a three-dimensional electrical field that has a field gradient which forms an electrical capture area, and the focus is at a distance from the capture are and b) the amplitude of the electrical field, the light power of the light beam forming the optical cage, and/or the distance of the capture area from the focus are varied to detect which varied field property moves the particle from the focus to the capture area or vice versa, or at least to temporarily move the particle into the capture area.Type: GrantFiled: December 21, 1998Date of Patent: January 31, 2006Assignee: Evotec Biosystems AGInventors: Günter Fuhr, Thomas Schnelle, Torsten Müller, Hermine Hitzler, Karl-Otto Greulich, Shamoi Monajembashi