Patents by Inventor Günter Mayer

Günter Mayer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220073921
    Abstract: The present invention relates to an aptamer comprising a nucleotide sequence SEQ ID NO: 1 or a fragment thereof of at least 20 contiguous nucleotides of the nucleotide sequence SEQ ID NO: 2, wherein the aptamer comprises a polyethylene glycol (PEG) moiety conjugated to the 5? or the 3? end. The invention further relates to a composition comprising the aptamer, and the use of the aptamer in the diagnosis and treatment of cancer, particularly hormone refractory prostate tumours.
    Type: Application
    Filed: January 20, 2020
    Publication date: March 10, 2022
    Applicant: RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN
    Inventors: Frédéric DUCONGÉ, Andreas LINGNAU, Holger WEBER, Michael KUBBUTAT, Günter MAYER
  • Publication number: 20210310004
    Abstract: The invention relates to a method of identifying or producing an aptamer, the method comprising the steps of: a) Providing a candidate mixture of nucleic acids; b) Contacting the candidate mixture with a target sample; c) Partitioning nucleic acids that bind to the target sample from those that do not bind; d) Amplifying the binding nucleic acids to produce a population of nucleic acids that bind the target sample; e) Single strand displacement of the amplified nucleic acids, f) optionally repeating the steps a) to e), thereby identifying or producing an aptamer, wherein the target sample provides one or more peptides and/or proteins in a denatured form.
    Type: Application
    Filed: July 29, 2019
    Publication date: October 7, 2021
    Applicant: RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN
    Inventors: Günter MAYER, Nora KARNOWSKI, Maren HAMANN, Tjasa LEGEN
  • Patent number: 10941176
    Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a target such as PARP1, HIST1H1B, HIST1H1D, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, or a complex, subunit or fragment thereof.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: March 9, 2021
    Assignee: Caris Science, Inc.
    Inventors: Heather O'Neill, Günter Mayer, Mark Miglarese, David Spetzler
  • Publication number: 20190359983
    Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a member of a ribonucleoprotein or spliceosomal complex such heterologous nuclear ribonucleoprotein U (hnRNP U).
    Type: Application
    Filed: February 2, 2018
    Publication date: November 28, 2019
    Inventors: Heather O'Neill, Günter Mayer, Sonal Tonapi, Vaishali Pannu, Mark Miglarese, David Spetzler
  • Publication number: 20190256546
    Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a target such as PARP1, HIST1H1B, HIST1H1D, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, or a complex, subunit or fragment thereof.
    Type: Application
    Filed: July 28, 2016
    Publication date: August 22, 2019
    Inventors: Heather O'Neill, Günter Mayer, Mark Miglarese, David Spetzler
  • Patent number: 9939443
    Abstract: Methods are provided for selecting aptamers that are specific to a target of interest from amongst a library of potential aptamer sequences. Aptamers disclosed can be used to detect and/or characterize biological entities of interest, e.g. microvesicles and/or surface antigens. Further disclosed are biomarkers that can be used for diagnosing different disorders including different types of cancer.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: April 10, 2018
    Assignee: Caris Life Sciences Switzerland Holdings GmbH
    Inventors: David Spetzler, Valeriy Domenyuk, Tassilo Hornung, Günter Mayer, Michael Famulok
  • Publication number: 20170298343
    Abstract: The invention relates to a method of identifying or producing an aptamer, and a reagent comprising a nucleic acid ligand capable of binding a target sample, wherein the nucleic acid ligand comprises at least one nucleobase modified to contain an azide-alkyne chemical group.
    Type: Application
    Filed: September 30, 2015
    Publication date: October 19, 2017
    Inventors: Guenter Mayer, Fabian Tolle
  • Patent number: 9790507
    Abstract: The present invention relates to an aptamer comprising a nucleotide sequence SEQ ID NO: 1, a composition comprising an aptamer, and the use of the aptamer in the diagnosis and treatment of cancer, particularly solid tumors.
    Type: Grant
    Filed: May 26, 2014
    Date of Patent: October 17, 2017
    Assignee: RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT BONN
    Inventors: Günter Mayer, Ursula Maria Katia Schöler, Mohammad Seyed Taghdisi Heidarian
  • Publication number: 20160152981
    Abstract: The present invention relates to an aptamer comprising a nucleotide sequence SEQ ID NO: 1, a composition comprising an aptamer, and the use of the aptamer in the diagnosis and treatment of cancer, particularly solid tumours
    Type: Application
    Filed: May 26, 2014
    Publication date: June 2, 2016
    Inventors: Günter Mayer, Ursula Maria Katia Schöler, Mohammad Seyed Taghdisi Heidarian
  • Publication number: 20160069889
    Abstract: Methods are provided for selecting aptamers that are specific to a target of interest from amongst a library of potential aptamer sequences. Aptamers disclosed can be used to detect and/or characterize biological entities of interest, e.g. microvesicles and/or surface antigens. Further disclosed are biomarkers that can be used for diagnosing different disorders including different types of cancer.
    Type: Application
    Filed: December 19, 2013
    Publication date: March 10, 2016
    Inventors: David SPETZLER, Valeriy DOMENYUK, Tassilo HORNUNG, Günter MAYER, Michael FAMULOK
  • Patent number: 8846645
    Abstract: The present invention relates to compounds according to general formula (I), pharmaceutical compositions comprising compounds according to general formula (I) and the use of the compounds for the treatment of a bacterial infection, particularly for use as an antibiotic.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: September 30, 2014
    Assignees: Rheinische Friedrich-Wilhelms Universität Bonn, Universität Konstanz
    Inventors: Günter Mayer, Christina Elsbeth Luense, Valentin Wittmann, Magnus S. Schmidt
  • Patent number: 8667697
    Abstract: The invention relates to an eccentric gear arrangement of a motor-driven, hand-guided hedge trimmer (1). The eccentric gear arrangement includes two shearing blades (2, 3) driven in mutually opposite directions over a displacement path (a). Each shearing blade has a connecting link (4, 5) as well as an eccentric wheel (6) having a drive wheel (7) and two eccentrics (8, 9). The eccentric wheel (6) rotates about a rotational axis (10). The two connecting links (4, 5) lie directly above one another. The two eccentrics (8, 9) are arranged on the same side of the drive wheel (7) and engage each in one of the two connecting links (4, 5). The two shearing blades (2, 3) have contact pressure surfaces (11, 12) in the region of their two connecting links (4, 5) and are offset with respect to each other in such a manner that they are exposed at least over a portion of the displacement path (a). Two downholders (13, 14) are provided which act each on one of the assigned contact pressure surfaces (11, 12).
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: March 11, 2014
    Assignee: Andreas Stihl AG & Co. KG
    Inventors: Markus Hittmann, Ralf Schenk, Reinhard Friedrich, Günter Mayer
  • Publication number: 20140066409
    Abstract: The present invention relates to compounds according to general formula (I), pharmaceutical compositions comprising compounds according to general formula (I) and the use of the compounds for the treatment of a bacterial infection, particularly for use as an antibiotic.
    Type: Application
    Filed: December 13, 2011
    Publication date: March 6, 2014
    Applicants: UNIVERSITÄT KONSTANZ, RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT BONN
    Inventors: Günter Mayer, Christina Elsbeth Luense, Valentin Wittmann, Magnus S. Schmidt
  • Patent number: 8612500
    Abstract: A method to generate a magnitude result of a mathematic operation of two decimal operands within one cycle in a decimal arithmetic logic unit structure, wherein the decimal operands are in hexadecimal sign magnitude format.
    Type: Grant
    Filed: January 14, 2008
    Date of Patent: December 17, 2013
    Assignee: International Business Machines Corporation
    Inventors: Wilhelm Haller, Ulrich Krauch, Guenter Mayer, Eric M. Schwarz
  • Publication number: 20130096901
    Abstract: A mechanism is provided for verifying design modifications to a simulation design unit included within a simulation model of an integrated electronic device. A modified description is received of a simulation design unit that failed to meet an expected physical property value during an initial simulation of the entire integrated electronic device. A simulation of the simulation design unit is executed using a list of identified input signals from a trace file. The trace file is generated during the initial simulation and indicates state values for the list of identified input signals. A determination is made as to whether the simulation of the simulation design unit fails to meet the expected physical property value. An indication is generated that modifications made to an initial description of the simulation design unit are successful in response to the simulation of the simulation design unit meeting the expected physical property value.
    Type: Application
    Filed: October 12, 2011
    Publication date: April 18, 2013
    Applicant: International Business Machines Corporation
    Inventors: Wolfgang Gellerich, Guenter Mayer, Chung-Lung K. Shum, Kai Weber
  • Patent number: 8001411
    Abstract: A method for generating a local clock domain within an operation includes steps of: receiving a clock frequency measurement for a slow portion of logic within the operation; generating a local signal to indicate commencement of the operation and to function as a clock gating signal; latching the clock gating signal to a selected cycle; generating clock domain controls based on the clock gating signal such that the operation times itscommencement on the selected cycle; and propagating the clock gating signal in ungated latches for a number of cycles, such that a second operation is restricted from being launched until the operation completes.
    Type: Grant
    Filed: September 24, 2007
    Date of Patent: August 16, 2011
    Assignee: International Business Machines Corporation
    Inventors: Sean Michael Carey, William Vincent Huott, Christian Jacobi, Guenter Mayer, Timothy Gerard McNamara, Chung-Lung Kevin Shum, Hans-Werner Tast, Michael Hemsley Wood
  • Patent number: 7755394
    Abstract: A circuit (01) combining level shift function with gated reset is described, performing a simple logic function with inputs supplied from a lower voltage (VD) and a drive out at its output (05) with a higher voltage (VC). Said circuit (01) comprises a gated reset scheme plus devices (10, 30, 40) for logic function.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: July 13, 2010
    Assignee: International Business Machines Corporation
    Inventors: Thomas Froehnel, Guenter Mayer, Rolf Sautter, Otto Wagner
  • Patent number: 7727646
    Abstract: The invention concerns a fuel cell comprising an anode chamber, a cathode chamber and a cavity for the electrolytic space, as well as combustion gas supply conduits and carbon dioxide and water discharge conduits for the anode chamber, and, for the cathode chamber, oxygen and carbon dioxide supply conduits and discharge conduits for residual oxygen and residual carbon dioxide. The anode chamber and the cathode chamber receive a metal sponge, the cathode chamber housing a metal or ceramic sponge. Said fuel cell is subdivided into an anode chamber, an outer cathode chamber and a median cathode chamber, separate cavities for electrolytic space located between the anode chamber and the median cathode chamber and the median cathode chamber and the outer cathode chamber.
    Type: Grant
    Filed: February 7, 2005
    Date of Patent: June 1, 2010
    Inventor: Günter Mayer
  • Publication number: 20090186244
    Abstract: The invention concerns a fuel cell comprising an anode chamber, a cathode chamber and a cavity for the electrolytic space, as well as combustion gas supply conduits and carbon dioxide and water discharge conduits for the anode chamber, and, for the cathode chamber, oxygen and carbon dioxide supply conduits and discharge conduits for residual oxygen and residual carbon dioxide. The anode chamber and the cathode chamber receive a metal sponge, the cathode chamber housing a metal or ceramic sponge. Said fuel cell is subdivided into an anode chamber, an outer cathode chamber and a median cathode chamber, separate cavities for electrolytic space located between the anode chamber and the median cathode chamber and the median cathode chamber and the outer cathode chamber.
    Type: Application
    Filed: February 7, 2005
    Publication date: July 23, 2009
    Inventor: Günter Mayer
  • Publication number: 20090112963
    Abstract: A method, circuit apparatus, and a design structure on which the circuit resides, is provided to perform a subtraction of two operands in a binary arithmetic unit by subdividing two operands into groups of equal numbers of bits, generating, by appropriate arithmetic operations, pairs of intermediate results for the particular groups of bits of the two operands comprising the same bit positions, respectively. A first intermediate result of each pair of intermediate results is generated under the assumption of a carry-in of ‘0’ and a second intermediate result of each pair of intermediate results is generated under the assumption of a carry-in of ‘1’. The correct intermediate result of each particular pair of intermediate results from each group of bits is selected, and the result of the subtraction of the two operands is generated by an appropriate merging of the selected correct intermediate results.
    Type: Application
    Filed: October 29, 2007
    Publication date: April 30, 2009
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Wilhelm Haller, Guenter Mayer, Veit Gernhoefer, Ulrich Krauch, Simon Fabel