Abstract: A device for extracting an interstitial fluid sample from the skin of a mammal subject is disclosed. The device comprises at least one micro-needle comprising a tip portion configured to be inserted into the skin of the mammal subject, and a passage configured to transport the interstitial fluid from the skin to a retaining material arranged in a channel of a body of the device. The retaining material is fluidically connected to the passage and configured to absorb and store the interstitial fluid sample transported by the passage. A holder configured to receive such a device is also disclosed.

Abstract: A microneedle particle arranged to be rolled and massaged on a subject's skin to penetrate the stratum corneum is disclosed. The microparticle comprises a support body, and a plurality of microneedles protruding from the support body (20), each microneedle comprising a tip. The support body maintains the microneedles and tips in a predetermined conformation allowing the microneedle particle to be rolled on the skin. The microneedles have an average tip sharpness radius of less than 20 ?m, an average microneedle length of less than 100 ?m, and an average tip sharpness to microneedle length ratio of 1:5 to 1:200. Formulations and kits for said use are provided. A microneedle particle manufacturing method using a non-linear two-photon absorption process, a non-therapeutic cosmetic method of skin treatment, and a method of drug delivery through the skin for said microneedle particle are disclosed.

Abstract: Disclosed herein is a microfluidic device and a method for transporting and sampling a defined volume of plasma, providing a fluid passageway from an inlet to an outlet comprising a first region with the inlet with a first high flow resistance configured to receive and collect a whole blood sample and to separate plasma; and a second region with the outlet lower flow resistance. The second region is in fluid connection with the first region and configured to meter the separated plasma by comprising a metering channel.

Abstract: A method for assembling one or more microchips into respective holes in a substrate surface of a separate receiving substrate for microchip insertion that is out-of-plane in relation to the substrate surface. The microchips are placed on the substrate surface and moved by one or more magnetic fields affecting a ferromagnetic layer of each microchip so that the microchips become out-of-plane oriented in relation to the substrate surface and are assembled into the holes.

Abstract: A spray nozzle chip comprising: a first layer provided with a first layer orifice, and a mechanically flexible nozzle layer provided with a nozzle orifice, wherein the first layer has a valve seat arranged aligned with the nozzle orifice, wherein the spray nozzle chip has a valve functionality obtained by movement of the nozzle layer relative to the valve seat due to pressure changes, and wherein the nozzle layer is arranged at a distance from the valve seat when the nozzle layer is in a default non-pressurised state, whereby a gap with a gap length (L) is formed between the nozzle layer and the valve seat, wherein the gap length (L) is smaller than a dimension of a specific bacterial type, to thereby seal against bacterial ingrowth through the nozzle orifice of the specific bacterial type.

Abstract: A capillary driven microfluidic device with blood plasma separation means that can be used to separate, meter and transfer a blood sample. The blood separation means can be arranged as a capillary pump by the configuration of a porous membrane and the microfluidic device.

Abstract: A biopsy device for sampling cells or tissue in a subject, the biopsy device comprising: a tubular member defining a lumen; and an elongated member movably arranged within the lumen of the tubular member, wherein a distal portion of the elongated member comprises a tissue capture arrangement including a plurality of rigid protrusions.

Abstract: A method for forming a monolithic swirl nozzle configured to aerosolize a pharmaceutical drug. The swirl nozzle comprises an inlet for receiving the pharmaceutical drug to be aerosolized; a swirl chamber connected to the inlet and configured to aerosolize the pharmaceutical drug provided by the inlet; and an outlet connected to the swirl chamber and configured to discharge the aerosolized pharmaceutical drug. The method comprises providing a photoactivatable material and forming the swirl nozzle by selectively activating voxels in the photoactivatable material.

Abstract: A microneedle (100) for extracting a blood sample from the skin (10) of a mammal subject is disclosed. The microneedle comprises at least one substantially flat blade (110) comprising at least one cutting edge (120a, 120b) configured to incise the skin of the mammal subject, and at least one microchannel (130) comprising an opening (132) and a passage (134). The at least one microchannel is arranged adjacent to the at least one blade and configured to be inserted into the skin of the mammal subject together with the at least one blade. The passage is configured to transport the blood sample away from the opening via capillary action. A device (200) for extracting a blood sample from a mammal subject comprising a microneedle is also disclosed.

Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.

Abstract: A device for extracting an interstitial fluid sample from the skin of a mammal subject is disclosed. The device comprises at least one micro-needle comprising a tip portion configured to be inserted into the skin of the mammal subject, and a passage configured to transport the interstitial fluid from the skin to a retaining material arranged in a channel of a body of the device. The retaining material is fluidically connected to the passage and configured to absorb and store the interstitial fluid sample transported by the passage. A holder configured to receive such a device is also disclosed.

Abstract: A microbiopsy device for extracting a tissue sample, the microbiopsy device comprising a main body extending between a distal end and a proximal end and adapted to have or assume a shape of substantially uniform transverse width along the length of the main body, wherein the distal end is arranged to enter tissue; the proximal end comprises a mounting interface adapted for connection with an elongated member, or is integrally formed with a solid elongated member; the transverse width of the main body is smaller than 1 mm; and the main body comprises a recess extending in a longitudinal direction of the main body and defining a cavity arranged to capture tissue therein.

Abstract: A method for transferring an atomically thin layer comprising providing a target substrate and a donor substrate on which a first atomically thin layer has been formed. The method further comprises disposing an adhesion layer at the donor substrate or at the target substrate. The method further comprises bringing the target substrate and the donor substrate together. Further, the method comprises bonding together the donor substrate, the adhesion layer and the target substrate and removing the donor substrate.

Abstract: The microfluidic device has a first reservoir that preferably includes a first liquid. The first liquid is being held by a capillary stop valve in the first reservoir. A second reservoir is in fluid communication with the first reservoir. The second reservoir has a second liquid and a sample support disposed therein. The second reservoir has an inlet opening defined therein. A draining unit is adjacent to the second reservoir. The draining unit is in fluid communication with the second reservoir. The draining unit has a first absorption member disposed therein.

Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.

Abstract: Method and arrangement for assembling one or more microchips (415; 615; 715; 815; 915; 1015) into one or more holes (422; 722), respectively, in a substrate surface (421; 721) of a separate receiving substrate (420; 720; 820; 1020). The holes (422; 722) of the substrate is for microchip insertion out-of-plane in relation to said substrate surface. Each of said microchips is provided with a ferromagnetic layer (213; 613) of ferromagnetic material. The microchips are placed (503) on said substrate surface (421; 721) and it is applied and moved (504) one or more magnetic fields affecting said ferromagnetic layer (213; 613) of each microchip such that the microchips thereby become out-of-plane oriented in relation to said substrate surface (421; 721) and move over the substrate surface (421; 721) until assembled into said holes (422; 722).

Abstract: Disclosed is a method of making a crack structure on a substrate, the crack structure being usable as a tunnelling junction structure in a nanogap device, including the controlled fracture or release of a patterned layer under built-in stress, thereby forming elements separated by nanogaps or crack-junctions. The width of the crack-defined nanogap is controlled by locally release-etching the film at a notched bridge patterned in the film. The built-in stress contributes to forming the crack and defining of the width of the crack-defined nanogap. Further, by design of the length of the bridge in a range between sub-??? to >25???, the separation between the elements, defined by the width of the crack-defined nanogaps, can be controlled for each individual crack structure from <2 nm to >100 nm. The nanogaps can be used for tunneling devices in combination with nanopores for DNA, RNA or peptides sequencing.

Abstract: The present invention relates to a method for forming a 3D optical component comprising the steps of: forming over a substrate a liquid layer of a polymer in a solvent, drying said polymer for removing at least a portion of said solvent and thereby creating a layer having a first dissolution rate, exposing by multi-photon absorption using an electromagnetic radiation source a predefined volume of said layer, thereby causing the volume to have a second dissolution rate which is different to said first dissolution rate, dissolve the non-exposed areas with a liquid solution for forming the 3D optical component, wherein said polymer is Hydrogen silsesquioxane, HSQ, and said dried layer having a thickness of at least 1 ?m.

Abstract: A method for transferring an atomically thin layer comprising providing a target substrate and a donor substrate on which a first atomically thin layer has been formed. The method further comprises disposing an adhesion layer at the donor substrate or at the target substrate. The method further comprises bringing the target substrate and the donor substrate together. Further, the method comprises bonding together the donor substrate, the adhesion layer and the target substrate and removing the donor substrate.

Abstract: The microfluidic device has a first reservoir that preferably includes a first liquid. The first liquid is being held by a capillary stop valve in the first reservoir. A second reservoir is in fluid communication with the first reservoir. The second reservoir has a second liquid and a sample support disposed therein. The second reservoir has an inlet opening defined therein. A draining unit is adjacent to the second reservoir. The draining unit is in fluid communication with the second reservoir. The draining unit has a first absorption member disposed therein.