Patents by Inventor G. Sridhar
G. Sridhar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10174062Abstract: The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinsae activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.Type: GrantFiled: December 19, 2016Date of Patent: January 8, 2019Assignee: Metabasis Therapeutics, Inc.Inventors: Feng Tian, Qun Dang, G. Sridhar Prasad, Wenyu Li, Brett C. Bookser, Nicholas Brian Raffaele, Mark D. Erion
-
Patent number: 10005805Abstract: The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinsae activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.Type: GrantFiled: December 19, 2016Date of Patent: June 26, 2018Assignee: Metabasis Therapeutics, Inc.Inventors: Feng Tian, Qun Dang, G. Sridhar Prasad, Wenyu Li, Brett C. Bookser, Nicholas Brian Raffaele, Mark D. Erion
-
Publication number: 20170096440Abstract: The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinsae activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.Type: ApplicationFiled: December 19, 2016Publication date: April 6, 2017Inventors: Feng Tian, Qun Dang, G. Sridhar Prasad, Wenyu Li, Brett C. Bookser, Nicholas Brian Raffaele, Mark D. Erion
-
Patent number: 9522926Abstract: The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinsae activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.Type: GrantFiled: December 29, 2014Date of Patent: December 20, 2016Assignee: Metabasis Therapeutics, Inc.Inventors: Feng Tian, Qun Dang, G. Sridhar Prasad, Wenyu Li, Brett C. Bookser, Nicholas Brian Raffaele, Mark D. Erion
-
Publication number: 20150119365Abstract: The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinsae activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.Type: ApplicationFiled: December 29, 2014Publication date: April 30, 2015Inventors: Feng Tian, Qun Dang, G. Sridhar Prasad, Wenyu Li, Brett C. Bookser, Nicholas Brian Raffaele, Mark D. Erion
-
Patent number: 8940927Abstract: The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinase activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.Type: GrantFiled: May 25, 2011Date of Patent: January 27, 2015Assignee: Metabasis Therapeutics, Inc.Inventors: Feng Tian, Qun Dang, G. Sridhar Prasad, Wenyu Li, Brett C. Bookser, Nicholas Brian Raffaele, Mark D. Erion
-
Publication number: 20110294758Abstract: The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinsae activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.Type: ApplicationFiled: May 25, 2011Publication date: December 1, 2011Applicant: Metabasis Therapeutics, Inc.Inventors: Feng Tian, Qun Dang, G. Sridhar Prasad, Wenyu Li, Brett C. Bookser, Nicholas Brian Raffaele, Mark D. Erion
-
Publication number: 20060149990Abstract: A fault identification system analyzes alarm information and the associated contextual information to identify the occurred faults. The contextual information is based on usecases, transactions, and functions associated with the electronic system under consideration. Multiple detectors that form part of knowledge repositories are used in the process of fault identification.Type: ApplicationFiled: March 2, 2006Publication date: July 6, 2006Applicant: Satyam Computer Services LimitedInventors: Veena S., G. Sridhar, V. Sridhar, K. Rao
-
Publication number: 20040260589Abstract: Enterprises procure a large number of licenses of a large number of software packages. Software package inventory is one of the high cost items in these enterprises. It is necessary to contain this recurring expenditure on software packages by optimally utilizing the procured licenses. Disclosed is a system and method for maximizing software package license utilization. The system includes components for enabling managers of an enterprise to describe their need for software packages in project plans and users to use the software packages based on such plans. Further, the system also manages unplanned demands to use software packages and maintains a near-optimal inventory of licenses of software packages.Type: ApplicationFiled: June 17, 2003Publication date: December 23, 2004Inventors: Sridhar Varadarajan, G. Sridhar, Korrapati Kalyana Rao
-
Publication number: 20040209344Abstract: The invention relates to molecules or molecular complexes which comprise binding pockets of angiotensin-converting enzyme-related carboxypeptidase or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to angiotensin-converting enzyme-related carboxypeptidase protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising angiotensin-converting enzyme-related carboxypeptidase protein or angiotensin-converting enzyme-related carboxypeptidase protein complexes.Type: ApplicationFiled: September 9, 2003Publication date: October 21, 2004Inventors: Michael W. Pantoliano, M. Dominic Ryan, Bart Lee Staker, G. Sridhar Prasad, Jin Tang, Saurabh Prabhakar Menon, Paul S. Towler, David H. Williams, Martin Fisher
-
Publication number: 20040010733Abstract: A fault identification system consisting of multiple reasoning engines and the blackboard analyzes alarm information and the associated contextual information to identify faults. The contextual information associated with an alarm is derived by analyzing the alarm along four spaces, namely, transaction-space, function-space, execution-space, and signal-space. The reasoning engines associated with these spaces infer and/or validate the occurrences of faults. Transaction reasoning engine, using the associated knowledge repository, processes the generated alarms to infer and validate faults. Monitor reasoning engine, using the associated knowledge repository, processes domain specific monitor variables to infer faults. Execution reasoning engine, using the associated knowledge repository, processes execution specific monitor variables to infer and validate faults. Function reasoning engine, using the associated knowledge repository, reasons to infer and validate faults.Type: ApplicationFiled: July 10, 2002Publication date: January 15, 2004Inventors: Veena S., G. Sridhar, V. Sridhar, K. Kalyana Rao
-
Publication number: 20030208754Abstract: An advertisement system that provides subscribers with the most relevant advertisements based on their individual purchase prediction of the various products and contextual information such as location, ongoing public events, festivals and personal events. The system customizes the advertisements to suit the audiovisual, language, and textual caption preferences of the subscribers. System provides for tracking of various promotional offers made to the subscribers from the time the offer is made to the time it is redeemed by the subscriber. System consists of methods to learn (a) purchase predictions (b) preferred streaming schedule and (c) the subscriber's preferences in terms of audiovisual aspects of the advertisements. Purchase prediction for individual subscriber is derived from historical purchase data by time series analysis and the influence of events such as co-purchases of other products and organized events such as sales exhibitions and festivals is derived based on Bayesian network models.Type: ApplicationFiled: May 1, 2002Publication date: November 6, 2003Inventors: G. Sridhar, V. Sridhar, K. Kaliana Rao
-
Patent number: 5297553Abstract: An ultrasound transducer comprising an array of individual piezoelectric transducer elements mounted upon an improved backing comprising rigid polymeric or polymer-coated particles fused into a macroscopically rigid structure having remnant tortuous permeability to provide high acoustic attenuation and to permit fluid passage into the backing structure during fabrication.Type: GrantFiled: September 23, 1992Date of Patent: March 29, 1994Assignee: Acuson CorporationInventors: John W. Sliwa, Jr., Sevig Ayter, Champa G. Sridhar, John P. Mohr, III, Samuel M. Howard, Michael H. Ikeda