Patents by Inventor G. Steven Bova
G. Steven Bova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190367990Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide.Type: ApplicationFiled: December 20, 2018Publication date: December 5, 2019Inventors: Srinivasan Yegnasubramanian, G. Steven Bova, Martin Aryee, William B. Isaacs, William G. Nelson
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Patent number: 10196698Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide.Type: GrantFiled: May 18, 2017Date of Patent: February 5, 2019Assignee: The Johns Hopkins UniversityInventors: Srinivasan Yegnasubramanian, G. Steven Bova, Martin Aryee, William B. Isaacs, William G. Nelson
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Publication number: 20180100196Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide.Type: ApplicationFiled: May 18, 2017Publication date: April 12, 2018Inventors: Srinivasan Yegnasubramanian, G. Steven Bova, Martin Aryee, William B. Isaacs, William G. Nelson
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Publication number: 20140274767Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide.Type: ApplicationFiled: January 23, 2014Publication date: September 18, 2014Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Srinivasan Yegnasubramanian, G. Steven Bova, Martin Aryee, William B. Isaacs, William G. Nelson
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Patent number: 7252212Abstract: A liquid storage and dispensing system, and methods for its use in the storage, shipping, and accurate dispensing by manual or automated methods, of, for example, precious biologic samples such as protein, DNA or RNA, with minimal contamination, oxidation, and evaporation, the system having: an essentially cylindrical storage barrel with a flange at its open end and a port and delivery tip at the closed end; a piston with a seal, where the piston closely matches the shape of the closed end of the barrel to minimize dead volume; and a cover to seal the delivery tip during storage such as cryostorage.Type: GrantFiled: May 3, 2004Date of Patent: August 7, 2007Inventors: Muniswamappa Anjanappa, David T. Bach, G. Steven Bova, Steven L. Paul, James J. Bach
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Publication number: 20040256415Abstract: A liquid storage and dispensing system, and methods for its use in the storage, shipping, and accurate dispensing by manual or automated methods, of, for example, precious biologic samples such as protein, DNA or RNA, with minimal contamination, oxidation, and evaporation, the system having: an essentially cylindrical storage barrel with a flange at its open end and a port and delivery tip at the closed end; a piston with a seal, where the piston closely matches the shape of the closed end of the barrel to minimize dead volume; and a cover to seal the delivery tip during storage such as cryostorage.Type: ApplicationFiled: May 3, 2004Publication date: December 23, 2004Inventors: Muniswamappa Anjanappa, David T. Bach, G. Steven Bova, Steven L. Paul, James J. Bach
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Patent number: 6773903Abstract: A process and apparatus for cell purification and ablation is disclosed. The present invention comprises a laser system which directs radiant energy at computer or manually selected individual cells thereby disrupting DNA, RNA and protein structure in those cells. The present invention produces a purified tissue section containing relatively intact DNA, RNA or protein from only the untreated cells. This purified sample is suitable for amplification of material by PCR or other techniques for the analysis of molecular genetic features in the selected cells of interest.Type: GrantFiled: October 24, 2001Date of Patent: August 10, 2004Inventor: G. Steven Bova
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Publication number: 20040044650Abstract: A method of distributing research data from a common database to a user of the common database is provided. Data concerning research results and data upon which the research results are based are stored in a local database and are linked to each other. Data concerning research results and data upon which the research results are based are selectively extracted from the local database to the common database. Research data are then selected by a user of the common database from the extracted data concerning research results and from the data upon which the extracted data are based and the selected research data are distributed to the user.Type: ApplicationFiled: September 4, 2003Publication date: March 4, 2004Applicant: The John Hopkins University, a Maryland corporationInventor: G. Steven Bova
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Patent number: 6675166Abstract: A method of distributing research data from a common database to a user of the common database is provided. Data concerning research results and data upon which the research results are based are stored in a local database and are linked to each other. Data concerning research results and data upon which the research results are based are selectively extracted from the local database to the common database. Research data are then selected by a user of the common database from the extracted data concerning research results and from the data upon which the extracted data are based and the selected research data are distributed to the user.Type: GrantFiled: December 4, 2000Date of Patent: January 6, 2004Assignee: The John Hopkins UniversityInventor: G. Steven Bova
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Publication number: 20030203461Abstract: A process and apparatus for cell purification and ablation is disclosed. The present invention comprises a laser system which directs radiant energy at computer or manually selected individual cells thereby disrupting DNA, RNA and protein structure in those cells. The present invention produces a purified tissue section containing relatively intact DNA, RNA or protein from only the untreated cells. This purified sample is suitable for amplification of material by PCR or other techniques for the analysis of molecular genetic features in the selected cells of interest.Type: ApplicationFiled: May 5, 2003Publication date: October 30, 2003Inventor: G. Steven Bova
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Publication number: 20020025511Abstract: A process and apparatus for cell purification and ablation is disclosed. The present invention comprises a laser system which directs radiant energy at computer or manually selected individual cells thereby disrupting DNA, RNA and protein structure in those cells. The present invention produces a purified tissue section containing relatively intact DNA, RNA or protein from only the untreated cells. This purified sample is suitable for amplification of material by PCR or other techniques for the analysis of molecular genetic features in the selected cells of interest.Type: ApplicationFiled: October 24, 2001Publication date: February 28, 2002Inventor: G. Steven Bova
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Publication number: 20010049681Abstract: A method of distributing research data from a common database to a user of the common database is provided. Data concerning research results and data upon which the research results are based are stored in a local database and are linked to each other. Data concerning research results and data upon which the research results are based are selectively extracted from the local database to the common database. Research data are then selected by a user of the common database from the extracted data concerning research results and from the data upon which the extracted data are based and the selected research data are distributed to the user.Type: ApplicationFiled: December 4, 2000Publication date: December 6, 2001Inventor: G. Steven Bova
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Patent number: 6316234Abstract: A process and apparatus for cell purification and ablation is disclosed. The present invention comprises a laser system which directs radiant energy at computer or manually selected individual cells thereby disrupting DNA, RNA and protein structure in those cells. The present invention produces a purified tissue section containing relatively intact DNA, RNA or protein from only the untreated cells. This purified sample is suitable for amplification of material by PCR or other techniques for the analysis of molecular genetic features in the selected cells of interest.Type: GrantFiled: October 28, 1999Date of Patent: November 13, 2001Inventor: G. Steven Bova
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Patent number: 6040139Abstract: A process and apparatus for cell purification and ablation is disclosed. The present invention comprises a laser system which directs radiant energy at computer or manually selected individual cells thereby disrupting DNA, RNA and protein structure in those cells. The present invention produces a purified tissue section containing relatively intact DNA, RNA or protein from only the untreated cells. This purified sample is suitable for amplification of material by PCR or other techniques for the analysis of molecular genetic features in the selected cells of interest.Type: GrantFiled: September 19, 1995Date of Patent: March 21, 2000Inventor: G. Steven Bova