Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: An example method is performed by a first medical device and includes generating first data indicating a physiological parameter of a subject; generating a filter configured to remove an artifact associated with a treatment; and generating second data by applying the filter to the first data. The example method further includes determining that a second medical device is administering the treatment to the subject. In response to determining that the second medical device is administering the treatment to the subject, the first medical device outputs an indication that filtering is available; receives an input signal selecting the filtering; and in response to receiving the input signal, displays the second data.

Abstract: An example method is performed by a computing device executing instructions stored in data storage, and includes receiving physiologic monitoring data from a plurality of sensors coupled to a patient, receiving information indicating a measurement of patient motion during the patient care event, determining whether the measurement of patient motion is above a threshold, based on determining whether the measurement of patient motion is above the threshold, generating, for the physiologic monitoring data, a respective quality indicator, analyzing, by the computing device, (i) a combination of the physiologic monitoring data from the plurality of sensors and (ii) the respective quality indicator for the physiologic monitoring data to generate a response dependent upon the combination of the physiologic monitoring data as weighted by the respective quality indicator, and based on analyzing, outputting caregiver feedback by the computing device according to the response.

Abstract: An example method is performed by a medical device and includes detecting an analog signal indicating a physiological parameter of a subject; converting the analog signal to first data; and determining a treatment parameter characterizing a treatment administered to the subject by a second medical device. The method further includes generating a filter characterized by the treatment parameter; generating second data by applying the filter to the first data; and displaying, on a user interface, the first data and the second data, wherein the second data is emphasized on the user interface.

Abstract: Various systems, methods, and devices related to modifying views of a multi-lead electrocardiogram (ECG), as well as identifying notations associated with the multi-lead ECG, are described. An example method includes displaying graphical elements in a first arrangement. The graphical elements respectively depict electrical signals indicative of an electrical activity of a heart. The example method further includes detecting a signal indicative of a display selection, and, based on the display selection, rearranging the graphical elements from the first arrangement to a second arrangement.

Abstract: A wearable cardioverter defibrillator monitor case includes a housing configured to surround a defibrillator electronics assembly, a front cover removably attachable to the housing, and a rear cover removably attachable to the housing. The wearable cardioverter defibrillator case has a shock indicator positioned on the housing at an interface between the housing and the front cover.

Abstract: There is provided a fit testing method comprising: providing a respirator donned by a wearer; providing a sensor in electrical communication with a sensing element, where the sensor is configured to monitor a particulate concentration parameter of a gas space within the respirator, and a second particulate concentration parameter of a gas space outside the respirator, where the sensor is attached to the respirator such that the respirator such that the weight of the sensor is supported by the respirator; and providing a reader configured to communicate with the sensor, where the reader is configured to provide a respirator fit parameter based on a comparison of the particulate concentration within the respirator to the particulate concentration parameter outside the respirator.

Abstract: Systems and methods described herein relate to determining physiological parameters and associated reliability of the physiological parameters and displaying the data in a manner that conveys the reliability information to a user. The reliability index is determined and then used to determine one or more display attributes for displaying the underlying parameter data while also conveying the reliability information. The implementations described herein provide for displaying physiological parameters in a manner that is easily digested and understood while also conveying a reliability in such data, without filling or cluttering a display with background or additional data that is typically used in a manual method to evaluate the data on the display.

Abstract: The present disclosure relates generally to methods of using modulators of COT (cancer Osaka thyroid) for treating, stabilizing, or lessening the severity or progression of liver disease, in particular, Nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH).

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Abstract: A wearable cardioverter defibrillator monitor case includes a housing configured to surround a defibrillator electronics assembly, a front cover removably attachable to the housing, and a rear cover removably attachable to the housing. The wearable cardioverter defibrillator case has a shock indicator positioned on the housing at an interface between the housing and the front cover.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Abstract: An example method is performed by a computing device executing instructions stored in data storage, and includes receiving physiologic monitoring data from a plurality of sensors coupled to a patient, receiving information indicating a measurement of patient motion during the patient care event, determining whether the measurement of patient motion is above a threshold, based on determining whether the measurement of patient motion is above the threshold, generating, for the physiologic monitoring data, a respective quality indicator, analyzing, by the computing device, (i) a combination of the physiologic monitoring data from the plurality of sensors and (ii) the respective quality indicator for the physiologic monitoring data to generate a response dependent upon the combination of the physiologic monitoring data as weighted by the respective quality indicator, and based on analyzing, outputting caregiver feedback by the computing device according to the response.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: A prehospital telemedicine system comprises a physiologic monitor; an electronic patient care reporting system (ePCR) system; and a point-of-care blood analyzer communicatively coupled to the physiologic monitor and the ePCR system. The point-of-care blood analyzer is configured to perform an analysis of a blood sample based on an indication of a need for a specific blood analysis provided by one of the physiologic monitor and the ePCR system, and to automatically transmit a result of the analysis to a remote data receiving system. The indication of a need for a specific blood analysis may be based upon any one of the following: vital signs data obtained for a patient by the physiologic monitor; and/or current documentation or past medical history captured on or available through the ePCR system.

Abstract: Methods for providing guidance to a user wearing a head mounted display (HMD) are provided. One example method includes using a camera of the HMD to track the user wearing the HMD in a real-world space, and identifying a safe zone within the real-world space for interacting with a virtual reality space via the HMD. The method further includes detecting movements of the user in the real-world space. The method includes integrating content into the virtual reality space. The content is configured to provide guidance in direction of movement of the user toward the safe zone of the real-world space. If the user continues to move away from safe zone, pausing presentation of the virtual reality space, and resuming the presentation when the user is in the safe zone.