Abstract: One aspect of the present invention relates to a double stranded iRNA agent comprising an antisense strand which is complementary to a target gene; a sense strand which is complementary to said antisense strand; and one or more lipophilic moieties conjugated to one or more internal positions on at least one strand, optionally via a linker or carrier. Another aspect of the invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic moieties-conjugated double-stranded iRNAs.

Abstract: Reproduction accuracy of, for example a digital stereo audio signal, is improved by transmitting sample data as sub-signals such as frequency subband signals. In one or more subbands, corresponding components such as left and right stereo channels are combined so that only one composite signal is transmitted per subband. An indicator signal is transmitted, indicating which subbands are combined. Scale factor signals for all subbands, and for the relative intensity of the respective subband signals which were combined, may also be transmitted. In the receiver a subband signal is derived for each channel from the composite signal, before synthesis of the full channel signals which will be reproduced.