Abstract: This invention relates to cleaning the induction systems, the combustion chambers and exhaust systems of internal combustion engines. And, more particularly, to chemicals and mixtures of chemicals for removing the different types of carbon deposits encountered in internal combustion engines used in “road vehicles”. Carbon deposits were taken from the induction systems of these road vehicles for the purpose of bench testing such carbon and product development. More specifically, chemicals (i.e., solvents) and chemical mixes (i.e., solutions) have been accurately tested on such harvested carbon deposits for their ability to remove the various types of carbon deposits that accumulate within road vehicle internal combustion engines. Additionally this invention also relates to apparatus for delivering chemicals and chemical mixes.

Abstract: The present device is an electronically controlled safety system for use in firearms, comprising a shape memory actuator configured to connect a mechanical locking interface to a trigger mechanism interface comprising a point of connection to a firearm's trigger mechanism. This shape memory actuator can be controlled by use of an authentication system comprised of an RFID module and a control module. The user of the firearm can provide authorization to place the firearm in the armed position by placing an RFID tag having an activation code near the RFID module, which can then activate the shape memory actuator through the control module. When the mechanical locking interface is connected to the trigger mechanism interface a firearm's trigger mechanism is locked in place and the firearm is in a safe position and when the mechanical locking interface is not connected to the trigger mechanism is in an armed position.

Abstract: Methods for treating one or more diseases associated with neutral sphingomyelinase 2 (nSMase2) in a subject in need of treatment thereof, the method comprising administering to the subject a therapeutically effective amount of 2,6-dimethoxy-4-(5-phenyl-4-thiophen-2-yl-1H-imidazol-2-yl)-phenol (DPTIP) or a pharmaceutically acceptable salt thereof, are disclosed.

Abstract: A cake cutter includes a handle having an L-shaped blade extending therefrom. The blade includes a first section axially extending from an end of the handle and a second section perpendicularly extending from a distal end of the first section. Integrally molded with a central portion of each blade section is a raised ridge that is positioned a predetermined distance from either end of the blade section. Accordingly, the user can cut a precisely sized slice of cake or casserole by aligning the ridges with an outer edge of a cake.

Abstract: The present device is an electronically controlled safety system for use in firearms comprising a shape memory actuator configured to connect a mechanical locking interface to a trigger mechanism interface comprising a point of connection to a firearm's trigger mechanism. This shape memory actuator can be controlled by use of an authentication system comprising an RFID module and a control module. The user of the firearm can provide authorization to place the firearm in the armed position by placing an RFID tag having a certain activation code near the RFID module, which can then activate the shape memory actuator through the control module. When the mechanical locking interface is connected to the trigger mechanism interface a firearm's trigger mechanism is locked in place and the firearm is in a safe position and when it is not connected to the trigger mechanism it is in an armed position.

Abstract: A crossbar assembly for facilitating isolation of a sensor assembly from vibration of a payload mounting system on a vehicle comprising an outer crossbar segment, an inner crossbar segment, an isolator, and a damper. The outer crossbar segment comprises a payload mount interface operable to mount to a payload mount, and an outer isolator interface operable to mount to an isolator. The inner crossbar segment comprises a structure interface to mount to a structure, and an inner isolator interface operable to mount to the isolator. The isolator can be supported by the outer and inner crossbar segments. The damper is adjacent the isolator. The isolator is operable to deform in response to relative movement between the outer and inner crossbar segments. The isolator operates to partially decouple the outer crossbar segment from the inner crossbar segment and the damper dampens vibrations propagating between the outer and inner crossbar segments.

Abstract: A crossbar system for facilitating isolation of a sensor assembly from external vibrations of a support structure. The crossbar system comprises first and second crossbar assemblies and a payload mount, Each of the first and second crossbar assemblies comprises a crossbar segment and a slip plate damper. Each crossbar segment comprises a payload mount interface at a first end of the crossbar assembly and a first support structure interface at a second end of the crossbar assembly. Each slip plate damper is disposed about the crossbar segment and is slidably coupled to the crossbar segment to constrain movement in two lateral degrees of freedom and to facilitate movement in a longitudinal degree of freedom, Each slip plate damper comprises a second support structure interface at the second end of the crossbar assembly. The payload mount is coupled to the payload mount interfaces of the first and second crossbar assemblies.

Abstract: Tools, for example, fixed cutter drill bits, may be manufactured to include hard composite portions having reinforcing particles dispersed in a continuous binder phase and auxiliary portions that are more machinable than the hard composite portions. For example, a tool may include a hard composite portion having a machinability rating 0.2 or less; and an auxiliary portion having a machinability rating of 0.6 or greater in contact with the hard composite portion. The boundary or interface between the hard composite portion and the auxiliary portion may be designed so that upon removal of the most or all of the auxiliary portion the resultant tool has a desired geometry without having to machine the hard composite portion.

Abstract: A system for fabricating an infiltrated downhole tool for introduction into a wellbore includes a mold assembly including a binder bowl, a mold, a preformed blank, and a funnel. The binder bowl has a lower portion and a plurality of apertures extending through the lower portion. The preformed blank is disposed within the infiltration chamber to provide an attachment area for a body of the infiltrated downhole tool, and the funnel is disposed intermediate the binder bowl and the mold. The system further includes a binder flow channel which extends through at least one of the preformed blank, the funnel, or a displacement core disposed within the mold assembly, the blank being concentrically arranged around the displacement core.

Abstract: A crossbar assembly for facilitating isolation of a sensor assembly from vibration of a payload mounting system on a vehicle comprises an outer crossbar segment, an inner crossbar segment, and an isolator. The outer crossbar segment comprises a payload mount interface operable to mount to a payload mount, and an outer isolator interface operable to mount to an isolator. The inner crossbar segment comprises a structure interface to mount to a structure, and an inner isolator interface operable to mount to the isolator. The isolator can be supported by the outer and inner crossbar segments. The isolator comprises an elastomeric component operable to elastically deform in response to relative movement between the outer and inner crossbar segments. The isolator operates to partially decouple the outer crossbar segment from the inner crossbar segment and dampen vibrations propagating between the outer and inner crossbar segments.

Abstract: Systems and methods for routing prescription drug claims between a pharmacy and a plurality of pharmacy benefit managers (PBMs). The systems and methods implemented by one or more processing circuits. One method includes receiving a prescription drug claim from the pharmacy, the prescription drug claim comprising routing information that causes the pharmacy to send the prescription drug claim to the prescription drug claim routing system. The method further includes obtaining a set of rules for routing the prescription drug claim. The method further includes selecting a PBM from the plurality of PBMs by applying the set of rules to the prescription drug claim. The method further includes modifying the routing information of the prescription drug claim to include updated routing information corresponding to the selected PBM and sending the prescription drug claim to the selected PBM for processing in accordance with the updated routing information.

Abstract: Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), HIV-associated neurocognitive disorder (HAND), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and, in other aspects, for treating cancer, are provided.

Abstract: The present invention relates to the carbon deposit buildup in the internal combustion engine, or more specifically the removal of such carbon from the induction system, combustion chamber, and the exhaust system. The method is one in which a high volumetric flow rate of chemical/chemical mixes are used to remove a greater amount of carbon from the engine. These preferred chemical/chemical mix flow rates are 6 to 9 Gallons per hour, which is approximately 9 times the volumetric flow rate of the industry standard of 1 gallon per hour.

Abstract: The present device is an electronically controlled safety system for use in firearms comprising a shape memory actuator configured to connect a mechanical locking interface to a trigger mechanism interface comprising a point of connection to a firearm's trigger mechanism. This shape memory actuator can be controlled by use of an authentication system comprising an RFID module and a control module. The user of the firearm can provide authorization to place the firearm in the armed position by placing an RFID tag having a certain activation code near the RFID module, which can then activate the shape memory actuator through the control module. When the mechanical locking interface is connected to the trigger mechanism interface a firearm's trigger mechanism is locked in place and the firearm is in a safe position and when it is not connected to the trigger mechanism it is in an armed position.

Abstract: Systems, methods, and apparatuses are provided herein that track an integrated deviation of a physical property of a material that corresponds to a variation or defect in the material. In one embodiment, molten steel begins to solidify and move past an instrumented region of a mold. Sensors in the mold can detect a deviation in temperature of the instrumented region of the mold that signifies a variation or defect in the surface of the slab material as it solidifies. The systems, methods, and apparatuses track the integrated temperature deviation to more clearly visualize defects that may otherwise not be detectable by simply observing the temperatures of the mold and slab material in real time.

Abstract: A radiation treatment planning system and method for generating plans to treat plural target volumes, each associated with a prescribed dose, does not require delivery of radiation to every target volume from every beam direction. Allowing target volumes to be omitted for some control points facilitates generation of treatment plans that deliver less radiation dose to non-target tissues by allowing beam shaping to more closely fit the remaining target volumes. Simulated annealing using an objective function may be applied to determine parameters such as the number of control points for which a target volume is not targeted.

Abstract: The engine lubricating system can become contaminated with carbon deposits and sludge. Sludge is where the combustion by-products that have entered the oil base saturate this oil base, thus forming a thick carbon rich substance. Sludge is not wanted within the engine. Sludge and or carbon deposits in the motor oil cause problems. Such carbon deposits form in the motor oil from heat, pressure, and namely combustion gases that have leaked pasted the piston rings. Turpentine and terpenes, hereafter referred to as “terpenes”, have shown that these chemicals can breakdown carbon which has been deposited within the engine's oil base.

Abstract: The present device is an electronically controlled safety system for use in firearms, comprising a shape memory actuator configured to connect a mechanical locking interface to a trigger mechanism interface comprising a point of connection to a firearm's trigger mechanism. This shape memory actuator can be controlled by use of an authentication system comprised of an RFID module and a control module. The user of the firearm can provide authorization to place the firearm in the armed position by placing an RFID tag having an activation code near the RFID module, which can then activate the shape memory actuator through the control module. When the mechanical locking interface is connected to the trigger mechanism interface a firearm's trigger mechanism is locked in place and the firearm is in a safe position and when the mechanical locking interface is not connected to the trigger mechanism is in an armed position.

Abstract: Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), HIV-associated neurocognitive disorder (HAND), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and, in other aspects, for treating cancer or HIV-1, are provided.

Abstract: Generating a plan for radiation treatment of multiple target volumes such as, for example, multiple brain tumors, involves optimizing a grouping of the target volumes into subsets and generating treatment plans for each subset. Resulting treatment plans may minimize radiation dose to tissues outside of the target volumes. A radiation treatment planning system may be configured to operate in this manner and to upload control signals which cause a radiation therapy device such as a linear accelerator to execute the radiation treatment plans.