Abstract: The present invention relates to a pharmaceutical composition for preventing or treating fibrosis and, more specifically, to a pharmaceutical composition for preventing or treating fibrosis, comprising mitochondria as an active ingredient. When the pharmaceutical composition of the present invention comprising exogenous mitochondria as an active ingredient is administered to a subject suffering from fibrosis such as pulmonary fibrosis, hepatic fibrosis and renal fibrosis, the fibrosis of tissues may be inhibited. In addition, the pharmaceutical composition of the present invention effectively inhibits the expression of fibronectin, CTGF2, ?-SMA, collagen 1A and the like during treatment of TGF-?. Therefore, the pharmaceutical composition according to the present invention may be effectively used in the prevention or treatment of fibrosis.

Abstract: The present invention relates to a mitochondrion containing a compound having the anticancer efficacy and uses thereof. It was confirmed that the mitochondrion efficiently deliver the compound to the tumor, and the anticancer effect of the mitochondrion containing the compound was confirmed. In particular, when an antibody or a fragment thereof that specifically binds to a tumor is bound to the surface of mitochondrion, the compound may be delivered specifically to the tumor. Therefore, the mitochondrion containing the compound according to the present invention may be effectively used for the treatment of cancer because the side effects of the compound are few.

Abstract: In the present specification, a composition for improving skin transparency and a composition for reducing skin dullness are disclosed. The composition contains a mixed extract of Rosa multiflorae Fructus, black sesame, plum, quince, and pine nut as an active ingredient, wherein the Rosa multiflorae Fructus and black sesame may be germinated. Also, the composition has the effect of improving skin that has become dull due to the effects of aging, the external environment, stress, etc., so that the skin is made clear and transparent.

Abstract: Provided are a composition including coumestrol extracted from soybeans as an active ingredient, and a method of inhibiting cortisone reductase by applying it to skin of a subject.

Abstract: In the present specification, a composition for improving skin transparency and a composition for reducing skin dullness are disclosed. The composition contains a mixed extract of Rosa Multiflorae Fructus, black sesame, plum, quince, and pine nut as an active ingredient, wherein the Rosa Multiflorae Fructus and black sesame may be germinated. Also, the composition has the effect of improving skin that has become dull due to the effects of aging, the external environment, stress, etc., so that the skin is made clear and transparent.

Abstract: A device for face for forming a relatively high potential difference between power terminals of different polarities without a voltage booster circuit to make a lot of current flow through human skin such that function of iontophoresis may be remarkably improved and simultaneously for driving electrically-driven modules of a mask individually without an external power supply to stimulate entirely or partially. The massage device for face includes a mask including an accommodation formed therein and a terminal exposing hole of a terminal for making current to human skin, and at least one electrically-driven module accommodated in the accommodation of the mask, exposing two terminals of different polarities to the outside through the terminal exposing hole, a driving unit having a rotary shaft and a coil wrapping the rotary shaft, and increasing a potential difference between the two terminals using an induced electromotive force of the coil.

Abstract: Disclosed is a device for face for forming a relatively high potential difference between power terminals of different polarities without a voltage booster circuit to make a lot of current flow through human skin such that function of iontophoresis may be remarkably improved and simultaneously for driving electrically-driven modules of a mask individually without an external power supply to stimulate entirely or partially. The massage device for face includes a mask including an accommodation formed therein and a terminal exposing hole of a terminal for making current to human skin, and at least one electrically-driven module accommodated in the accommodation of the mask, exposing two terminals of different polarities to the outside through the terminal exposing hole, a driving unit having a rotary shaft and a coil wrapping the rotary shaft, and increasing a potential difference between the two terminals using an induced electromotive force of the coil.

Abstract: Disclosed is a composition for external skin application for preventing skin aging comprising pine knot extract as an effective ingredient. The composition prevents and improves wrinkles through of skin cell proliferation and collagen biosynthesis, and may be widely applied in the field of skin beauty care and cosmetics.