Abstract: A nanocomposite is provided, the nanocomposite comprising collagen nanoparticles loaded with theophylline. The nanocomposite is generally spherical and can have an average particle diameter ranging from about 30 nm to about 40 nm. The collagen nanoparticles can be derived from a marine source, such as mullet fish. The nanocomposite can be useful for treating bronchial asthma.

Abstract: A nanocomposite comprising collagen nanoparticles loaded with abscisic acid (ABA). can have an average particle diameter ranging from about 125 nm to about 185 nm. Collagen in the collagen nanoparticles can be derived from a marine source. The nanocomposite can effectively treat and prevent cardiac ischemia.

Abstract: The disclosure of the present patent application relates generally to the extraction and purification of abscisic acid (ABA) from strawberries and its application in medicine and disease treatment in mammals and specifically humans. The extraction and purification process uses gel column chromatography to provide a highly pure composition of ABA, and the application of such includes treating heart disease.

Abstract: A method of synthesizing silymarin-loaded collagen collagen nanoparticles can include dissolving silymarin in an alcohol to provide a solution, mixing the solution with acetic acid to provide an acetic acid mixture, and adding the glutaraldehyde to the mixture to provide silymarin nanoparticles. The silymarin nanoparticles can be dissolved in a further alcohol and mixed for a period of time to provide a silymarin nanoparticle mixture. Then, the silymarin nanoparticles can be mixed with collagen nanoparticles to provide a silymarin/collagen mixture. Glutaraldehyde can be added to the collagen mixture to provide the nanocomposite formulation.

Abstract: A method of treating and preventing Alzheimer's disease (AD) in a subject can include administering to a subject in need thereof a therapeutically effective amount of a nanocomposite formulation including nanosilymarin (silymarin nanoparticles) encapsulated within a collagen-based-polymeric nanoparticulate drug delivery system. The nanocomposite formulation can effectively treat and prevent Alzheimer's disease (AD) at dose ranging from about 100 mg/kg/day to about 300 mg/kg/day.