Patents by Inventor Gabor Butora

Gabor Butora has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIPID NANOPARTICLE COMPOSITIONS AND METHODS OF FORMULATING THE SAME
    Publication number: 20240016827
    Abstract: Provided herein are compositions and methods of reducing adduct formation.
    Type: Application
    Filed: June 2, 2023
    Publication date: January 18, 2024
    Applicant: ModernaTX, Inc.
    Inventors: Meredith Packer, Dipendra Gyawali, Serenus Hua, Gabor Butora, Gregory John Mercer
  • Trinucleotide mRNA cap analogs
    Patent number: 11866754
    Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: January 9, 2024
    Assignee: ModernaTX, Inc.
    Inventors: Gabor Butora, Matthew Stanton, Edward John Miracco
  • POLYNUCLEOTIDES CONTAINING A MORPHOLINO LINKER
    Publication number: 20230323344
    Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.
    Type: Application
    Filed: September 6, 2022
    Publication date: October 12, 2023
    Inventors: Gabor BUTORA, Andrew W. Fraley, Edward John Miracco, Jennifer Nelson, Amy Rhoden Smith, Matthew Stanton
  • Lipid nanoparticle compositions and methods of formulating the same
    Patent number: 11622972
    Abstract: Provided herein are compositions and methods of reducing adduct formation.
    Type: Grant
    Filed: June 27, 2022
    Date of Patent: April 11, 2023
    Assignee: MODERNATX, INC.
    Inventors: Meredith Packer, Dipendra Gyawali, Serenus Hua, Gabor Butora, Gregory John Mercer
  • Lipid nanoparticle compositions and methods of formulating the same
    Patent number: 11524023
    Abstract: Provided herein are compositions and methods of reducing adduct formation.
    Type: Grant
    Filed: October 22, 2021
    Date of Patent: December 13, 2022
    Assignee: MODERNATX, INC.
    Inventors: Meredith Packer, Dipendra Gyawali, Serenus Hua, Gabor Butora, Gregory John Mercer
  • LIPID NANOPARTICLE COMPOSITIONS AND METHODS OF FORMULATING THE SAME
    Publication number: 20220339185
    Abstract: Provided herein are compositions and methods of reducing adduct formation.
    Type: Application
    Filed: June 27, 2022
    Publication date: October 27, 2022
    Applicant: ModernaTX, Inc.
    Inventors: Meredith Packer, Dipendra Gyawali, Serenus Hua, Gabor Butora, Gregory John Mercer
  • Polynucleotides containing a morpholino linker
    Patent number: 11434486
    Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: September 6, 2022
    Assignee: ModernaTX, Inc.
    Inventors: Gabor Butora, Andrew W. Fraley, Edward John Miracco, Jennifer Nelson, Amy Rhoden Smith, Matthew Stanton
  • LIPID NANOPARTICLE COMPOSITIONS AND METHODS OF FORMULATING THE SAME
    Publication number: 20220273693
    Abstract: Provided herein are compositions and methods of reducing adduct formation.
    Type: Application
    Filed: October 22, 2021
    Publication date: September 1, 2022
    Inventors: Meredith Packer, Dipendra Gyawali, Serenus Hua, Gabor Butora, Gregory John Mercer
  • HIGH PURITY RNA COMPOSITIONS AND METHODS FOR PREPARATION THEREOF
    Publication number: 20220096521
    Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
    Type: Application
    Filed: November 10, 2021
    Publication date: March 31, 2022
    Applicant: ModernaTX, Inc.
    Inventors: Stephen Hoge, William Issa, Edward J. Miracco, Jennifer Nelson, Amy E. Rabideau, Gabor Butora
  • HIGH PURITY RNA COMPOSITIONS AND METHODS FOR PREPARATION THEREOF
    Publication number: 20220096522
    Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
    Type: Application
    Filed: November 10, 2021
    Publication date: March 31, 2022
    Applicant: ModernaTX, Inc.
    Inventors: Stephen Hoge, William Issa, Edward J. Miracco, Jennifer Nelson, Amy E. Rabideau, Gabor Butora
  • High purity RNA compositions and methods for preparation thereof
    Patent number: 11202793
    Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: December 21, 2021
    Assignee: ModernaTX, Inc.
    Inventors: Stephen Hoge, William Issa, Edward J. Miracco, Jennifer Nelson, Amy E. Rabideau, Gabor Butora
  • STEROL PURIFICATION
    Publication number: 20210347810
    Abstract: The invention relates to sterol esters and methods for producing purified sterols that can be utilized in methods for producing a lipid nanoparticle.
    Type: Application
    Filed: September 19, 2019
    Publication date: November 11, 2021
    Inventors: Gabor BUTORA, Jin LIM, Gary SHEN, Alison VOLKERT
  • High purity RNA compositions and methods for preparation thereof
    Patent number: 10653712
    Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: May 19, 2020
    Assignee: ModernaTX, Inc.
    Inventors: Stephen Hoge, William Issa, Edward J. Miracco, Jennifer Nelson, Amy E. Rabideau, Gabor Butora
  • Phosphate replacement MRNA cap analogs
    Patent number: 10570388
    Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the cap analogs.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: February 25, 2020
    Assignee: ModernaTX, Inc.
    Inventors: Gabor Butora, Matthew Stanton, Thomas Steele
  • Phosphate replacement mRNA cap analogs
    Patent number: 10563195
    Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the cap analogs.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: February 18, 2020
    Assignee: ModernaTX, Inc.
    Inventors: Gabor Butora, Matthew Stanton, Thomas Steele
  • Phosphate replacement mRNA cap analogs
    Patent number: 10428106
    Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: October 1, 2019
    Assignee: ModernaTX, Inc.
    Inventors: Gabor Butora, Matthew Stanton, Thomas Steele
  • ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF
    Publication number: 20190255194
    Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
    Type: Application
    Filed: March 1, 2019
    Publication date: August 22, 2019
    Inventors: Atanu ROY, Christopher R. CONLEE, Antonin DE FOUGEROLLES, Andrew W. FRALEY, Gabor BUTORA, Matthew STANTON
  • HIGH PURITY RNA COMPOSITIONS AND METHODS FOR PREPARATION THEREOF
    Publication number: 20190247417
    Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
    Type: Application
    Filed: September 14, 2017
    Publication date: August 15, 2019
    Applicant: ModernaTX, Inc.
    Inventors: Stephen Hoge, William Issa, Edward J. Miracco, Jennifer Nelson, Amy E. Rabideau, Gabor Butora
  • MRNA CAP ANALOGS AND METHODS OF MRNA CAPPING
    Publication number: 20190225644
    Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
    Type: Application
    Filed: October 17, 2016
    Publication date: July 25, 2019
    Inventors: Gabor BUTORA, Matthew STANTON, Thomas STEELE
  • MRNA CAP ANALOGS WITH MODIFIED PHOSPHATE LINKAGE
    Publication number: 20190218546
    Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
    Type: Application
    Filed: October 17, 2016
    Publication date: July 18, 2019
    Inventors: Gabor BUTORA, Matthew STANTON, Thomas STEELE