Abstract: One embodiment provides a method for treating atherosclerotic vascular disease in a subject in need thereof by administering to the subject an effective amount of a pharmaceutical composition comprising one or more inhibitors of macropinocytosis to inhibit or reduce receptor-independent LDL macropinocytosis in the subject. In one embodiment, the one or more inhibitors of macrophage macropinocytosis is imipramine or a derivative thereof or any additional macropinocytosis inhibitors independent of their effects on NHE1 activity. In some embodiments the macropinocytosis is macrophage macropinocytosis. A representative atherosclerotic vascular disease is atherosclerosis.

Abstract: A method and system for modelling atomic or molecular level structures, or the atomic or molecular energies or forces in such structures. The method and system use a Gaussian Process to estimate properties at the atom or molecular level in such structures.

Abstract: A method and system, for modelling atomic or molecular level structures or the atomic or molecular energies or forces in such structures is disclosed. The method and system use a Gaussian Process to estimate properties at the atom or molecular level in such structures.

Abstract: The invention is directed to compositions for use in dental preparations which comprise an anti-osteoporotic agent, particularly ipriflavone, an anti-phlogistic agent, particularly triamcinolone, and, optionally, a natural or synthetic chemotherapeutic agent or local anaesthetic. The invention is also directed to methods for preparation of the compositions and methods of their use for treating caries and for the healing of acute, subacute or chronic inflammatory lesion of pulp, dental radix or the bony substance surrounding them.