Patents by Inventor Gabor Gigler

Gabor Gigler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240091138
    Abstract: Topical formulation containing pregabalin for long-term analgesic activity. The composition is prepared using high pressure homogenization, which changes the structure of the composition. The analgesic effect of the compounds of the present invention is significantly increased compared to reference formulations homogenized with equipment of the same quantitative composition but less shearing forces.
    Type: Application
    Filed: January 24, 2022
    Publication date: March 21, 2024
    Applicant: EGIS GYÓGYSZERGYÁR ZRT.
    Inventors: Anita GULYÁS, Krisztina MÓRICZ, Dániel ULEJ, Gábor GIGLER, Edit PAPP, Adrienn PÁLVÖLGYI, István GACSÁLYI
  • Publication number: 20240082190
    Abstract: The present invention relates to a topical pharmaceutical composition comprising pregabalin and a reduced micellar phospholipid as an active ingredient, which results in a prolonged analgesic effect of pregabalin. The product can reduce neuropathic pain by at least 5 hours.
    Type: Application
    Filed: January 24, 2022
    Publication date: March 14, 2024
    Applicant: EGIS GYÓGYSZERGYÁR ZRT.
    Inventors: Anita GULYÁS, Krisztina MÓRICZ,, Dániel ULEJ, Gábor GIGLER, Edit PAPP, Adrienn PÁLVÖLGYI, István GACSÁLYI, Zoltán VARGA, András Ferenc WACHA, Attila BÓTA,
  • Publication number: 20240082192
    Abstract: Topical formulation containing pregabalin for long-term analgesic activity. The composition is prepared using high shear mixers or homogenizers such as HPH or ultrasonic devices, which changes the structure of the composition. The analgesic effect of the compounds of the present invention is significantly increased compared to reference formulations homogenized with equipment of the same quantitative composition but less shearing forces.
    Type: Application
    Filed: January 24, 2022
    Publication date: March 14, 2024
    Applicant: EGIS GYÓGYSZERGYÁR ZRT.
    Inventors: Anita GULYÁS, Krisztina MÓRICZ, Dániel ULEJ, Gábor GIGLER, Edit PAPP, Adrienn PÁLVÖLGYI, István GACSÁLYI, Zoltán VARGA, András Ferenc WACHA, Attila BÓTA
  • Publication number: 20240082191
    Abstract: The present invention relates to a topical pharmaceutical composition comprising pregabalin and a reduced micellar phospholipid as an active ingredient, which results in a prolonged analgesic effect of pregabalin. The product can reduce neuropathic pain by at least 5 hours.
    Type: Application
    Filed: January 24, 2022
    Publication date: March 14, 2024
    Applicant: EGIS GYÓGYSZERGYÁR ZRT.
    Inventors: Anita GULYÁS, Krisztina MÓRICZ, Dániel ULEJ, Gábor GIGLER, Edit PAP, Adrienn PÁLVÖLGYI, István GACSÁLYI, Zoltán VARGA, András Ferenc WACHA, Attila BÓTA
  • Patent number: 9926332
    Abstract: Compounds of formula (I) having a selective dual action on the central GABAergic system, and a process for their preparation and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: March 27, 2018
    Assignee: Egis Gyogyszergyar Zrt.
    Inventors: Agnes Kenez, Ferenc Bertha, Jozsef Barkoczy, Ferenc Antoni, Istvan Gacsalyi, Balazs Mihalik, Gabor Gigler, Krisztina Moricz, Gabor Nemeth, Agnes Angyalne Pataki, Gabor Laszlo Kapus, Adrienn Palvolgyi, Istvan Ling, Janos Petho, Gyula Simig, Balazs Volk, Lax Gyorgyi Kovanyine, Andras Dancso
  • Publication number: 20170002020
    Abstract: Compounds of formula (I) having a selective dual action on the central GABAergic system, and a process for their preparation and to pharmaceutical compositions containing them.
    Type: Application
    Filed: January 20, 2015
    Publication date: January 5, 2017
    Applicant: Egis Gyogyszergyar Zrt.
    Inventors: Agnes KENEZ, Ferenc BERTHA, Jozsef BARKOCZY, Ferenc ANTONI, Istvan GACSALYI, Balazs MIHALIK, Gabor GIGLER, Krisztina MORICZ, Gabor NEMETH, Agnes ANGYALNE PATAKI, Gabor Laszlo KAPUS, Adrienn PALVOLGYI, Istvan LING, Janos PETHO, Gyula SIMIG, Balazs VOLK, Lax Gyorgyi KOVANYINE, Andras DANCSO
  • Patent number: 8318743
    Abstract: The invention relates the use of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazole-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H)pyridazinone of the Formula (I) or pharmaceutically acceptable salts thereof for the preparation of medicaments suitable for the improvement of cognitive function or obtaining neuroprotective effect. The medicaments containing 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazol-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H)pyridazinone of the Formula (I) or therapeutically acceptable salt thereof can be used for the treatment or prevention of neuronal death, mental decline, sclerosis multiplex, Creuzfeld-Jacobs disease, Huntington-syndrome, amyotrophic lateral sclerosis, Parkinson-disease, memory disturbance, loss of memory, amnesia, stroke or for the improvement of memory function or learning ability.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: November 27, 2012
    Assignee: Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
    Inventors: Istvan Gacsalyi, Gabor Gigler, Marta Agoston, Hajnalka Kompagne, Szabolcs Kertesz, Krisztina Moricz, Gyoergy Levay, Gabor Szenas, Lászlo Gabor Harsing, Jozsef Barkoczy, Gyula Simig
  • Publication number: 20120252784
    Abstract: Novel 2,3,4-benzothiadiazepines-2,2-dioxides and processes for the preparation thereof are disclosed. The compounds influence the central nervous system and may be used to treat or prevent Alzheimer's disease, Parkinson's disease or Huntington's disease, senile dementia not of the Alzheimer's type, vascular dementia, post-stroke dementia, Korsakoff's syndrome, Down's syndrome, schizophrenia, panic disorder, post-traumatic stress disorder, anxiety or depression.
    Type: Application
    Filed: March 13, 2012
    Publication date: October 4, 2012
    Inventors: Jozsef FETTER, Ferenc BERTHA, Balazs MOLNAR, Gyula SIMIG, Jozsef BARKOCZY, Balazs VOLK, Gyoergy LEVAY, Istvan GACSALYI, Gabor GIGLER, Hajnalka KOMPAGNE, Bernadett MARKO, Katalin NAGY, Peter KIRICSI, Laszlo Gabor HARSING, Gabor SZENASI
  • Publication number: 20120108607
    Abstract: The present invention relates to the enantiomers of 5,7-dichloro-3-{4-[4-(4-chlorophenyl)-piperazin-1-yl]butyl}-3-ethyl-1,3-dihydro-2H-indol-2-one of the Formula (II) pharmaceutically acceptable salts thereof, process for the preparation thereof, medicinal products containing said enantiomers and the use thereof and their pharmaceutically acceptable salts in the treatment of the disorders of the central nervous system.
    Type: Application
    Filed: February 5, 2010
    Publication date: May 3, 2012
    Inventors: Balázs Volk, József Barkóczy, István Gacsalyi, Elemér Fogassy, József Schindler, Gábor Gigler, Hajnalka Kompagne, Iidikó Nagyné Gyoenos, Katalin Pallagi, Márta Porcs-Makkay, Gábor Szénási, Tibor Mezel, Gyula Lukács, Gyoergy Lévay, András Egyed, László Gábor Hársing
  • Patent number: 7960375
    Abstract: The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula —NH—R?, wherein R? stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives. The compounds according to the invention possess AMPA/kainate receptor inhibiting activity.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: June 14, 2011
    Assignee: Egis Gyogyszergyar Rt.
    Inventors: Jozsef Barkoczy, Istvan Ling, Gyula Simig, Gabor Szenasi, Gabor Gigler, Szabolcs Kertesz, Gyula Szücs, Geza Szabo, Miklos Vegh, Laszlo Gabor Harsing
  • Patent number: 7910591
    Abstract: The present invention is concerned with new indol-2-one derivatives of Formula (I), which have favorable activity profile for the prophylaxis and treatment of disorders in the central nervous or in the cadiovascular system.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: March 22, 2011
    Assignee: EGIS Gyogyszergyar NYRT.
    Inventors: Balázs Volk, József Barkóczy, Gyula Simig, Tibor Mezei, Rita Kapillerné Dezsöfi, István Gacsályi, Katalin Pallagi, Gábor Gigler, György Lévay, Krisztina Móricz, Csilla Leveleki, Nóra Sziray, Gábor Szenasi, András Egyed, László Gábor Hársing
  • Patent number: 7786129
    Abstract: The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein R1 stands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); R4 stands for alkyl having 1-7 carbon atom(s); R5 represents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R6, R7 and R8 each stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or R6 and R7 together represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: August 31, 2010
    Assignee: Egis Gyogyszergyar Nyrt
    Inventors: Balázs Volk, József Barkóczy, Gyula Simig, Tibor Mezei, Rita Kapillerné Dezsöfi, Endréné Flórian, István Gacsályi, Katalin Pallagi, Gábor Gigler, György Lévay, Krisztina Móricz, Csilla Leveleki, Nóra Sziray, Gábor Szénási, András Egyed, László Gábor Hársing
  • Publication number: 20100075975
    Abstract: The invention relates the use of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazole-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H) pyridazinone of the Formula (I) or pharmaceutically acceptable salts thereof for the preparation of medicaments suitable for the improvement of cognitive function or obtaining neuroprotective effect. The medicaments containing 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazol-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H) pyridazinone of the Formula (I) or therapeutically acceptable salt thereof can be used for the treatment or prevention of neuronal death, mental decline, sclerosis multiplex, Creuzfeld-Jacobs disease, Huntington-syndrome, amyotrophic lateral sclerosis, Parkinson-disease, memory disturbance, loss of memory, amnesia, stroke or for the improvement of memory function or learning ability.
    Type: Application
    Filed: July 3, 2007
    Publication date: March 25, 2010
    Inventors: István Gacsalyi, Gábor Gigler, Márta Agoston, Hajnalka Kompagne, Szabolcs Kertesz, Krisztina Moricz, György Levay, Gábor Szenas, László Gábor Harsing, József Barcoczy, Gyula Simig
  • Publication number: 20090306144
    Abstract: New 3,3-disubstituted indol-2-one derivatives of the general formula (I) Compounds according to the invention are useful for the prophylaxis or treatment of the disorders of the central nervous system.
    Type: Application
    Filed: July 28, 2009
    Publication date: December 10, 2009
    Inventors: Balazs VOLK, József Barkóczy, Gyula Simig, Tibor Mezei, Rita Kapillerné Dezsòfi, István Gacsályi, Katalin Pallagi, Gábor Gigler, György Lévay, Krisztina Móricz, Csilla Leveleki, Nóra Sziray, Gabor Szénási, András Egyed, Lászió Gábor Hársing
  • Publication number: 20090281137
    Abstract: The present invention is related to new 3,3-disubstituted indol-2-one derivatives of the general Formula (I) The new compounds are useful for the treatment or prophylaxis of the central nervous system, the gastrointestinal system or the cardiovascular system.
    Type: Application
    Filed: July 9, 2009
    Publication date: November 12, 2009
    Inventors: Balázs Volk, József Barkóczy, Gyula Simig, Tibor Mezei, Rita Kapillerné Dezsófi, István Gacsályi, Katalin Pallagi, Gábor Gigler, Gyôrgy Lévay, Krisztina Móricz, Csilla Leveleki, Nóra Sziray, Gábor Szénási, András Egyed, László Gábor Hársing
  • Publication number: 20090233913
    Abstract: The present invention relates to dihydro-2,3-benzodiazepine compounds of high enantiomeric purity according to the general formula (I), which contain an asymmetric centre at the position 4 of the dihydro-2,3-benzodiazepine compound, and the preparation thereof and the used intermediates as well. These compounds have anti-convulsiveA muscle relaxant and neuroprotective effect due their non-competitive AMPA antagonistic properties.
    Type: Application
    Filed: December 29, 2006
    Publication date: September 17, 2009
    Inventors: Istvan Ling, Jozsef Barkoczy, Zoltan Greff, Gabor Szenasi, Gabor Gigler, Szabolcs Kertesz, Gyula Szucs, Mihaly Albert, Gabor Kapus, Geza Szabo, Miklos Vegh, Marta Agoston, Gyorgy Levay, Krisztina Moricz, Laszlo Gabor Harsing
  • Publication number: 20080161323
    Abstract: The present invention is concerned with new indol-2-one derivatives of Formula (I), which have favourable activity profile for the prophylaxis and treatment of disorders in the central nervous or in the cadiovascular system.
    Type: Application
    Filed: May 11, 2005
    Publication date: July 3, 2008
    Applicant: EGIS GYOGYSZERGYAR RT.
    Inventors: Balazs Volk, Jozsef Barkoczy, Gyula Simig, Tibor Mezei, Rita Kapillerne Dezsofi, Istvan Gacsalyi, Katalin Pallagi, Gabor Gigler, Gyorgy Levay, Krisztina Moricz, Csilla Leveleki, Nora Sziray, Gabor Szenasi, Andras Egyed, Laszlo Gabor Harsing
  • Publication number: 20080153814
    Abstract: The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula —NH—R?, wherein R? stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives. The compounds according to the invention possess AMPA/kainate receptor inhibiting activity.
    Type: Application
    Filed: July 29, 2004
    Publication date: June 26, 2008
    Inventors: Jozsef Barkoczy, Istvan Ling, Gyula Simig, Gabor Szenasi, Gabor Gigler, Szabolcs Kertesz, Gyula Szucs, Geza Szabo, Miklos Vegh, Laszio Gabor Harsing
  • Publication number: 20070265300
    Abstract: The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I). Compounds according to the invention are useful for the prophylaxis or treatment of the disorders of the central nervous system.
    Type: Application
    Filed: May 10, 2005
    Publication date: November 15, 2007
    Applicant: Egis gyogyszergyar rt.
    Inventors: Balazs Volk, Jozsef Barkoczy, Gyula Simig, Tibor Mezei, Rita Kapillerne Dezsofi, Istvan Gacsalyi, Katalin Pallagi, Gabor Gigler, Gyorgy Levay, Krisztina Moricz, Csilla Leveleki, Nora Sziray, Gabor Szenasi, Andras Egyed, Laszlo Harsing
  • Publication number: 20070244102
    Abstract: The invention relates to a combined analgesic pharmaceutical composition which comprises as component: A) (1R,2S,4R)-(?)-2-[N,N-(dimethylaminoethoxy)]-2-phenyl-1,7-7-trimethylbicyclo[2.2.1]heptane or a pharmaceutically acceptable acid addition salt thereof and as component B) morphine, an opioide type analgesic and/or a non-opioide type analgesic in admixture with suitable pharmaceutical carriers and/or auxiliary agents. Deramciclane increases the analgesic effect of morphine.
    Type: Application
    Filed: March 12, 2004
    Publication date: October 18, 2007
    Inventors: Istvan Gacsalyi, Gabor Gigler, Laszlo Harsing, Gyorgy Levay, Gabor Szenasi