Abstract: The invention is directed to a stable complex with controlled particle size, increased apparent solubility and increased dissolution rate comprising as active compound Sirolimus or derivatives thereof, which is useful in the prophylaxis of organ rejection in patients receiving renal transplants, in the treatment of psoriasis, facial angiofibromas associated with tuberous sclerosis, fibrofolliculomas found in Birt-Hogg-Dubé Syndrome, chronic erosive oral lichen planus, Early Stage Cutaneous T-cell Lymphoma, Treatment of Autoimmune Active Anterior Uveitis, dry eye syndrome, age-related macular degeneration, diabetic macular edema, noninfectious uveitis, telangiectasia, inflammatory skin diseases (dermatitis, including psoriasis and lichen ruber planus), Pachyonychia Congenita and in the suppression of angiogenesis pathways.

Abstract: The invention relates to a nanostructured (nanoparticular) composition comprising Indomethacine, its pharmaceutically acceptable salts and co-crystals, processes for the preparation thereof, and compositions useful for pharmaceutical applications. The size of the nanoparticles according to the invention is smaller than 500 nm. Indomethacine (INN) or Indomethacine (USAN, previously BAN) is a non-steroidal anti-inflammatory drug (NSAID), which is used for the treatment of fever, inflammation, spasm, swells and inflammations. The machanism of action of Indomethacine is the inhibition of the synthesis of prostaglandin. It is marketed under the trade names of Indocin, Indocid, Indochron E-R, and Indocin-SR.

Abstract: The present invention is directed to nanostructured Aprepitant compositions, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Aprepitant according to the invention have an average particle size of less than about 200 nm. The stable nanostructured particles of the invention are presented by increased solubility, dissolution rate, permeability and bioequivalent or enhanced biological performance characterized by significantly decreased fed/fasted effect compared to the reference and marketed drug. Aprepitant is a chemical compound that belongs to a class of drugs called substance P antagonists (SPA). It mediates its effect by acting on neurokinin 1 receptor. Aprepitant is manufactured by Merck & Co. under the brand name Emend for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting.

Abstract: The present invention is directed to nanostructured Aprepitant compositions, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Aprepitant according to the invention have an average particle size of less than about 200 nm. The stable nanostructured particles of the invention are presented by increased solubility, dissolution rate, permeability and bioequivalent or enhanced biological performance characterized by significantly decreased fed/fasted effect compared to the reference and marketed drug. Aprepitant is a chemical compound that belongs to a class of drugs called substance P antagonists (SPA). It mediates its effect by acting on neurokinin 1 receptor. Aprepitant is manufactured by Merck & Co. under the brand name Emend for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting.

Abstract: The present invention is directed to nanostructured Ezetimibe compositions, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Ezetimibe according to the invention have an average particle size of less than about 400 nm. The stable nanostructured particles of the invention are presented by increased solubility, dissolution rate, permeability and bioequivalent or enhanced biological performance compared to the marketed drug. Ezetimibe is an anti-hyperlipidemic medication that is used to lower cholesterol levels. It acts by decreasing cholesterol absorption in the intestine.

Abstract: The present invention is directed to nanostructured Atorvastatin, its pharmaceutically acceptable salts and compositions of them, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Atorvastain, its pharmaceutically acceptable salts and compositions of them according to the invention have an average particle size of less than about 600 nm. The stable amorphous nanostructured particles of the present invention are characterized by increased solubility and bioequivalent biological performance compared to the marketed crystalline drug. Atorvastatin is a member of the drug class known as statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms.

Abstract: The present invention relates to a composition comprising: (a) a fragrance oil wherein the fragrance oil comprises: (i) greater than about 50%, by weight of the fragrance oil, of perfume raw materials with high odour impact perfume raw materials which have an odour detection threshold of less than, or equal to, about 50 parts per billion; (ii) less than about 5%, by weight of the fragrance oil, of top note perfume raw materials wherein the top note perfume raw materials have a boiling point of less than about 250° C. at 1 atmosphere pressure (b) an entrapment material which is selected from the group consisting of polymers; capsules, microcapsules, and nanocapsules; liposomes; pro-perfumes; film formers; absorbents; cyclic oligosaccharides and mixtures thereof. (c) greater than about 50%, by weight, of a volatile solvent.

Abstract: The present invention relates to a composition comprising: (a) a fragrance oil wherein the fragrance oil comprises: (i) one or more perfume raw materials with a high odour impact which have an odour detection threshold of less than, or equal to about 50 parts per billion (ii) less than about 4%, by weight of the fragrance oil, of top note perfume raw materials where in the top note perfume raw materials have a boiling point of less than 250° C.

Abstract: A composition comprising: (a) a fragrance oil wherein the fragrance oil comprises greater than 0.5% of a top note perfume raw material, or mixture of top note perfume raw materials, with a boiling point of less than, or equal to, 250° C. at 1 atmosphere pressure; (b) an entrapment material which is selected from the group consisting of polymers; capsules, microcapsules and nanocapsules; liposomes; film formers; absorbents; cyclic oligosaccharides and mixtures thereof; (c) greater than 50% volatile solvent; wherein the perfume raw material and the entrapment material exist in an associated form on the substrate and wherein the weight ratio of the top note perfume raw material to the entrapment material within the associated form is in the range from about 1:20 to about 20:1.

Abstract: The invention provides a method for improving release, on a surface, of a fragrance from an entrapment structure of at least one fragrance oil and at least one entrapment material. The method destabilizes the entrapment structure by providing at least one trigger molecule which preferentially associates with the entrapment material; and/or at least one release agent which at least partially disrupts the entrapment structure. The invention also provides a composition for improving release of a fragrance from a surface. The composition comprises at least one fragrance oil; at least one entrapment material, the at least one fragrance oil and the at least one entrapment material being capable, in use, of forming an entrapment structure on the surface.

Abstract: A composition comprising: (a) from about 0.01% to about 99%, by weight, of a fragrance oil, wherein the fragrance oil comprises about 5% or greater, by weight of fragrance oil, of a top note perfume raw material, or mixture of top note perfume raw materials, and wherein the top note perfume raw materials have a boiling point of less than, or equal to, about 250° C. at 1 atmosphere pressure; (b) an entrapment material which is selected from the group consisting of polymers; capsules, microcapsules and nanocapsules; liposomes; pro-perfumes selected from more than 1 type of pro-chemistry; film formers; absorbents; cyclic oligosaccharides and mixtures thereof; (c) greater than about 50% volatile solvent.

Abstract: A composition comprising: (a) a fragrance oil comprising: (i) top note perfume raw material, or mixture of perfume raw materials, with a boiling point of less than, or equal to, about 250° C. at 1 atmosphere pressure; (ii) middle or base note perfume raw material, or mixture of perfume raw materials, with a boiling point of greater than 250° C. at 1 atmosphere pressure; (b) an entrapment material which is selected from the group consisting of polymers; capsules, microcapsules and nanocapsules; liposomes; pro-perfumes selected from more than 1 type of pro-chemistry; film formers; absorbents; cyclic oligosaccharides and mixtures thereof; (c) greater than 50% volatile solvent; wherein the weight ratio of the top note perfume raw materials to middle or base note perfume raw materials within the fragrance oil is in the range from about 1:20 to about 20:1.

Abstract: The present invention relates to a composition comprising: (a) a fragrance oil wherein the fragrance oil comprises: (i) one or more perfume raw materials with a high odour impact which have an odour detection threshold of less than, or equal to about 50 parts per billion (ii) less than about 5%, by weight of the fragrance oil, of top note perfume raw materials where in the top note perfume raw materials have a boiling point of less than 250° C.

Abstract: The present invention relates to a composition comprising: (a) a fragrance oil wherein the fragrance oil comprises: (i) greater than about 50%, by weight of the fragrance oil, of perfume raw materials with high odour impact perfume raw materials which have an odour detection threshold of less than, or equal to, about 50 parts per billion; (ii) less than about 5%, by weight of the fragrance oil, of top note perfume raw materials wherein the top note perfume raw materials have a boiling point of less than about 250° C. at 1 atmosphere pressure (b) an entrapment material which is selected from the group consisting of polymers; capsules, microcapsules, and nanocapsules; liposomes; pro-perfumes; film formers; absorbents; cyclic oligosaccharides and mixtures thereof. (c) greater than about 50%, by weight, of a volatile solvent.

Abstract: A composition comprising: (a) a fragrance oil comprising: (i) top note perfume raw material, or mixture of perfume raw materials, with a boiling point of less than, or equal to, about 250° C. at 1 atmosphere pressure; (ii) middle or base note perfume raw material, or mixture of perfume raw materials, with a boiling point of greater than 250° C. at 1 atmosphere pressure; (b) an entrapment material which is selected from the group consisting of polymers; capsules, microcapsules and nanocapsules; liposomes; pro-perfumes selected from more than 1 type of pro-chemistry; film formers; absorbents; cyclic oligosaccharides and mixtures thereof; (c) greater than 50% volatile solvent; wherein the weight ratio of the top note perfume raw materials to middle or base note perfume raw materials within the fragrance oil is in the range from about 1:20 to about 20:1.

Abstract: The present invention provides a method of applying a fragrance to a surface such as skin and/or hair. The method comprises applying to one area of the surface a first composition wherein the first composition comprises at least one first fragrance oil; at least one first cyclic oligosaccharide, wherein the at least one first fragrance oil and the at least one first cyclic oligosaccharide form a complex, which complex is dissolved or dispersed in the first composition; and a first solvent, wherein the first solvent has a dielectric constant at 25° C. of greater than or equal to 43. The method also comprises simultaneously or sequentially, in either order, applying to the one area or an area adjacent thereto a second composition wherein the second composition comprises at least one second fragrance oil; and a second solvent wherein the at least one second fragrance oil is soluble or is dispersed at 25° C. in the second solvent.

Abstract: According to the present invention there is provided fragrance compositions comprising (a) fragrance; and (b) cyclic oligosaccharides having one or more unsubstituted alkyl substituents; wherein the weight ratio of (a) to (b) is at least about 1:1. The compositions of the present invention provide a long-lasting fragrance while at the same time having a ‘burst’ of fragrance on application.

Abstract: The invention provides a method for improving release, on a surface, of a fragrance from an entrapment structure of at least one fragrance oil and at least one entrapment material. The method destabilises the entrapment structure by providing at least one trigger molecule which preferentially associates with the entrapment material; and/or at least one release agent which at least partially disrupts the entrapment structure.

Abstract: The present invention provides a method of applying a fragrance to a surface such as skin and/or hair. The method comprises applying to one area of the surface a first composition wherein the first composition comprises at least one first fragrance oil; at least one first cyclic oligosaccharide, wherein the at least one first fragrance oil and the at least one first cyclic oligosaccharide form a complex, which complex is dissolved or dispersed in the first composition; and a first solvent or a mixture thereof, wherein the first solvent or the mixture thereof has a dielectric constant at 25° C. of greater than or equal to 43, preferably greater than or equal to 45.

Abstract: A composition comprising: