Patents by Inventor Gabor Patonay
Gabor Patonay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11738095Abstract: This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.Type: GrantFiled: February 2, 2017Date of Patent: August 29, 2023Assignee: Emory UniversityInventors: Leland W. K. Chung, Lucjan Strekowski, Chunmeng Shi, Maged Henary, Gabor Patonay, James J. Krutak, Xiaojian Yang, Guodong Zhu, Ruoxiang Wang, Haiyen E. Zhau
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Patent number: 10377901Abstract: Provided herein are heterocyclic near infrared compounds, including near IR compounds defined by Formulae I-V described herein. The near infrared compounds can include a cyanine group, a phthalocyanine group, a naphthalocyanine group, a squaraine group, a carbocyanine group, or a combination thereof. In some embodiments, the near infrared compound can be charged. In some embodiments, the near infrared compound can comprise a cationic group. Compositions comprising the near infrared compounds are also disclosed. In some embodiments, the composition can contain the near infrared compound, a polymer, and an acceptable carrier. In some embodiments, the polymer can include an anionic group. The compositions can be used as a coating for marking a surface, such as an ink. The compositions can also be used on articles for detecting, identifying, or authenticating the article. Methods of making the compositions described herein are also disclosed.Type: GrantFiled: August 12, 2015Date of Patent: August 13, 2019Assignee: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: Maged Henary, Gabor Patonay
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Publication number: 20180327427Abstract: This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[S—CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.Type: ApplicationFiled: July 23, 2018Publication date: November 15, 2018Applicant: Lahjavida, LLCInventors: James J. Krutak, Lyle Small, Maged Henary, Gabor Patonay
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Patent number: 10030036Abstract: This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.Type: GrantFiled: May 12, 2010Date of Patent: July 24, 2018Assignee: Lahjavida, LLCInventors: James J. Krutak, Lyle Small, Maged Henary, Gabor Patonay
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Publication number: 20170354747Abstract: This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.Type: ApplicationFiled: February 2, 2017Publication date: December 14, 2017Inventors: Leland W.K. Chung, Lucjan Strekowski, Chunmeng Shi, Maged Henary, Gabor Patonay, James J. Krutak, Xiaojian Yang, Guodong Zhu, Ruoxiang Wang, Haiyen E. Zhau
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Publication number: 20170233577Abstract: Provided herein are heterocyclic near infrared compounds, including near IR compounds defined by Formulae I-V described herein. The near infrared compounds can include a cyanine group, a phthalocyanine group, a naphthalocyanine group, a squaraine group, a carbocyanine group, or a combination thereof. In some embodiments, the near infrared compound can be charged. In some embodiments, the near infrared compound can comprise a cationic group. Compositions comprising the near infrared compounds are also disclosed. In some embodiments, the composition can contain the near infrared compound, a polymer, and an acceptable carrier. In some embodiments, the polymer can include an anionic group. The compositions can be used as a coating for marking a surface, such as an ink. The compositions can also be used on articles for detecting, identifying, or authenticating the article. Methods of making the compositions described herein are also disclosed.Type: ApplicationFiled: August 12, 2015Publication date: August 17, 2017Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: Maged Henary, Gabor Patonay
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Publication number: 20150376209Abstract: This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.Type: ApplicationFiled: May 12, 2010Publication date: December 31, 2015Inventors: JAMES J. KRUTAK, Lyle Small, Maged Henary, Gabor Patonay
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Publication number: 20150335765Abstract: This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.Type: ApplicationFiled: July 31, 2015Publication date: November 26, 2015Inventors: Leland W.K. Chung, Lucjan STREKOWSKI, Chunmeng SHI, Maged HENARY, Gabor PATONAY, James J. KRUTAK, Xiaojian YANG, Guodong ZHU, Ruoxiang WANG, Haiyen E. ZHAU
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Publication number: 20150183736Abstract: This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.Type: ApplicationFiled: March 12, 2015Publication date: July 2, 2015Inventors: Leland W.K. Chung, Lucjan STREKOWSKI, Chunmeng SHI, Maged HENARY, Gabor PATONAY, James J. KRUTAK, Xiaojian YANG, Guodong ZHU, Ruoxiang WANG, Haiyen E. ZHAU
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Publication number: 20110262354Abstract: This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.Type: ApplicationFiled: July 10, 2008Publication date: October 27, 2011Inventors: Leland W. K. Chung, Ruoxiang Wang, Haiyen E. Zhau, Lucjan Strekowski, Maged Henary, Gabor Patonay, James J. Krutak, Xiaojian Yang, Guodong Zhu
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Patent number: 6086737Abstract: To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.Type: GrantFiled: July 11, 1995Date of Patent: July 11, 2000Assignee: Li-Cor, Inc.Inventors: Gabor Patonay, Narasimhachari Narayanan, John A. Brumbaugh, Lyle Richard Middendorf
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Patent number: 5959296Abstract: An apparatus for detecting an invisible, near infrared fluorescing mark disposed on a background comprises: includes an excitation source for exciting the mark, having sufficient power to excite the mark and provide a fluorescent signal the mark from a; a signal detector for detecting the fluorescent signal from the mark; a and power modulator means for varying the power if the excitation source between zero and the maximum power level to produce a decodable fluorescent signal from the mark disposed on the background. A process for decoding an invisible mark having a near infrared fluorescing material includes the steps of: providing at least one invisible, near infrared fluorescing mark disposed on at least one portion of a background; exciting the mark with a laser having a maximum power level sufficient to provide a fluorescent signal from the mark; detecting the fluorescent signal and concurrently varying the power of the laser between zero and its maximum power, to obtain a decodable fluorescent signal.Type: GrantFiled: June 20, 1997Date of Patent: September 28, 1999Assignee: Eastman Chemical CompanyInventors: Michael John Cyr, James John Krutak, Sr., Horst Clauberg, Randy Barnett Meade, James Edward Moore, Gabor Patonay
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Patent number: 5800995Abstract: To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.Type: GrantFiled: August 30, 1996Date of Patent: September 1, 1998Assignee: Li-Cor, Inc.Inventors: Gabor Patonay, Narasimhachari Narayanan, Lucjan Strekowski, Lyle Richard Middendorf, Malgorzata Lipowska
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Patent number: 5703229Abstract: Provided are new compounds useful as near infrared fluorophoric markers. In the practice of this invention a method is also provided for tagging thermoplastic containers using near infrared fluorescing compounds or copolymerized residues readily capable of detection. The new compounds are phthalocyanine and naphthalocyanine derivatives which are covalently bonded to substituted silicon and aluminum compounds. The methods, compositions, and compounds described herein thus provide a total system useful for marking, for identification purposes, the various classes of thermoplastic wastes, so that they can be identified, sorted, and subsequently recycled.Type: GrantFiled: February 29, 1996Date of Patent: December 30, 1997Assignee: Eastman Chemical CompanyInventors: James J. Krutak, Michael R. Cushman, Clarence A. Coates, William W. Parham, Max A. Weaver, Gabor Patonay
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Patent number: 5639874Abstract: To sequence DNA automatically, DNA marked with near infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a scanning light frequency within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission frequency of the marked DNA. The light is modulated from said laser at a predetermined modulation frequency and fluorescent light emitted by said DNA bands at said modulation frequency is detected, whereby background noise from the medium through which the light is transmitted is discriminated against.Type: GrantFiled: June 28, 1994Date of Patent: June 17, 1997Assignee: Li-Cor, Inc.Inventors: Lyle Richard Middendorf, Gabor Patonay
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Patent number: 5571388Abstract: To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.Type: GrantFiled: March 1, 1994Date of Patent: November 5, 1996Assignee: Li-Cor, Inc.Inventors: Gabor Patonay, Narasimhachari Narayanan, Lucjan Strekowski, Lyle R. Middendorf, Malgorzata Lipowska
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Patent number: 5553714Abstract: Provided is a method for tagging thermoplastic containers using near infrared fluorescing compounds or copolymerized residues readily capable of detection. Also provided is a method for identifying a thermoplastic container. Also provided are thermoplastic polymer compositions comprised of the near infrared fluorescing compounds or residues and articles comprised of such compositions.Type: GrantFiled: November 14, 1994Date of Patent: September 10, 1996Assignee: Eastman Chemical CompanyInventors: Michael R. Cushman, James J. Krutak, William W. Parham, Clarence A. Coates, Max A. Weaver, Gabor Patonay
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Patent number: 5461136Abstract: Provided is a method for tagging thermoplastic containers using near infrared fluorescing compounds or copolymerized residues readily capable of detection. Also provided is a method for identifying a thermoplastic container. Also provided are thermoplastic polymer compositions comprised of the near infrared fluorescing compounds or residues and articles comprised of such compositions. Also provided are new compounds useful as near infrared fluorophoric markers in the practice of this invention. The methods, compositions, and compounds of the present invention thus provide a total system useful for marking, for identification purposes, the various classes of thermoplastic wastes, so that they can be identified, sorted, and subsequently recycled.Type: GrantFiled: June 27, 1994Date of Patent: October 24, 1995Assignee: Eastman Chemical CompanyInventors: James J. Krutak, Michael R. Cushman, Clarence A. Coates, William W. Parham, Max A. Weaver, Gabor Patonay
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Patent number: 5423432Abstract: Provided are water-dissipatable, sulfo-containing polyesters and polyester-amides having copolymerized therein thermally stable near infrared flourophoric compounds. The polymers are useful in coating or ink compositions, which are in turn useful for marking articles for identification/authentication purposes. Also provided is a method for invisibly marking such articles and a method for detecting and sorting articles by utilizing the near infrared flourophoric ink or coating compositions.Type: GrantFiled: May 5, 1994Date of Patent: June 13, 1995Assignee: Eastman Chemical CompanyInventors: James J. Krutak, Michael R. Cushman, William W. Parham, Clarence A. Coates, Max A. Weaver, Gabor Patonay
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Patent number: 5397819Abstract: Provided is a method for tagging thermoplastic containers using near infrared fluorescing compounds or copolymerized residues readily capable of detection. Also provided is a method for identifying a thermoplastic container. Also provided are thermoplastic polymer compositions comprised of the near infrared fluorescing compounds or residues and articles comprised of such compositions. Also provided are new compounds useful as near infrared fluorophoric markers in the practice of this invention. The methods, compositions, and compounds of the present invention thus provide a total system useful for marking, for identification purposes, the various classes of thermoplastic wastes, so that they can be identified, sorted, and subsequently recycled.Type: GrantFiled: November 24, 1993Date of Patent: March 14, 1995Assignee: Eastman Chemical CompanyInventors: James J. Krutak, Michael R. Cushman, Clarence A. Coates, William W. Parham, Max A. Weaver, Gabor Patonay