Patents by Inventor Gabriel Birkus

Gabriel Birkus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3?3? CYCLIC DINUCLEOTIDES WITH AN ALKENYLENE
    Publication number: 20230303613
    Abstract: The present disclosure describes 3?3? cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of substances and other medicaments or pharmaceuticals. The disclosure also describes the use of compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. These substances can be used as adjuvants in vaccines.
    Type: Application
    Filed: April 15, 2021
    Publication date: September 28, 2023
    Inventors: Gabriel BIRKUS, Milan DEJMEK, Radim NENCKA, Tomas OTAVA, Michal SALA, Ondrej PAV
  • 3?3?-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
    Patent number: 11766447
    Abstract: The present disclosure relates to 3?3?-cyclic dinucleotides having a carbocyclic nucleotide and derivatives that can modulate the activity of the STING adaptor protein.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: September 26, 2023
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel Birkus, Petra Brehova, Milan Dejmek, Radim Nencka, Ondrej Pav, Michal Sala
  • 3'3'-CYCLIC DINUCLEOTIDE ANALOGUE COMPRISING A CYCLOPENTANYL MODIFIED NUCLEOTIDE AS STING MODULATOR
    Publication number: 20220160746
    Abstract: The present disclosure relates to 3?3?-cyclic dinucleotides having a carbocyclic nucleotide and derivatives that can modulate the activity of the STING adaptor protein.
    Type: Application
    Filed: March 4, 2020
    Publication date: May 26, 2022
    Applicant: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I
    Inventors: Gabriel BIRKUS, Petra BREHOVA, Milan DEJMEK, Radim NENCKA, Ondrej PAV, Michal SALA
  • 2'3'-CYCLIC DINUCLEOTIDES AND PRODRUGS THEREOF
    Publication number: 20220152078
    Abstract: The present disclosure relates to 2?3? cyclic phosphonate dinucleotides of Formula (I), the pharmaceutically acceptable salts, pharmaceutical composition and combinations of the substances and other medicaments or pharmaceuticals. The disclosure also relates to the compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases.
    Type: Application
    Filed: March 4, 2020
    Publication date: May 19, 2022
    Applicant: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel BIRKUS, Ondrej PAV, Ondrej KOSTOV, Petra BREHOVA, Martin Maxmilian KAISER, Ondrej SIMAK
  • 3'3'-CYCLIC DINUCLEOTIDES AND PRODRUGS THEREOF
    Publication number: 20220143061
    Abstract: The present disclosure relates to 3?3? cyclic phosphonate dinucleotides of general formula (I), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of the substances and other medicaments or pharmaceuticals. The disclosure also relates to compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases.
    Type: Application
    Filed: March 4, 2020
    Publication date: May 12, 2022
    Applicant: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel BIRKUS, Ondrej PAV, Petra BREHOVA, Ondrej SIMAK
  • 3?3?-cyclic dinucleotides
    Patent number: 11292812
    Abstract: The present invention relates to 3?3?-cyclic dinucleotides modified with a 3?-phosphonoalkyl bond and derivatives thereof, that can modulate the activity of the STING adaptor protein.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: April 5, 2022
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel Birkus, Ondrej Pav, Ivan Rosenberg, Ondrej Simak
  • 2?3? cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
    Patent number: 11203610
    Abstract: The present disclosure relates to 2?3? cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: December 21, 2021
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel Birkus, Ondrej Pav, Tomas Jandusik, Ivan Rosenberg, Radim Nencka
  • 2?3?-cyclic dinucleotides
    Patent number: 11149052
    Abstract: The present disclosure relates to 2?3?-cyclic dinucleotides modified with a 2?- or 3?-phosphonoalkyl bond and derivatives thereof, that can modulate the activity of the STING adaptor protein.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: October 19, 2021
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel Birkus, Ondrej Pav, Ivan Rosenberg, Ondrej Simak
  • 3?3? cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
    Patent number: 10966999
    Abstract: Provided herein are the 3?3? cyclic phosphonate dinucleotides of general formula J, their pharmaceutically acceptable salts, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: April 6, 2021
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel Birkus, Ondrej Pav, Tomas Jandusik, Ivan Rosenberg, Radim Nencka
  • 2'3'-CYCLIC DINUCLEOTIDES COMPRISING CARBOCYCLIC NUCLEOTIDE
    Publication number: 20190359645
    Abstract: The present disclosure relates to 2?3?-cyclic dinucleotides comprising a carbocyclic nucleotide and derivatives thereof, that can modulate the activity of the STING adaptor protein.
    Type: Application
    Filed: May 2, 2019
    Publication date: November 28, 2019
    Inventors: Gabriel Birkus, Milan Dejmek, Radim Nencka, Ondrej Pav, Michal Sala
  • 3'3'-CYCLIC DINUCLEOTIDES
    Publication number: 20190322696
    Abstract: The present invention relates to 3?3?-cyclic dinucleotides modified with a 3?-phosphonoalkyl bond and derivatives thereof, that can modulate the activity of the STING adaptor protein.
    Type: Application
    Filed: April 4, 2019
    Publication date: October 24, 2019
    Inventors: Gabriel Birkus, Ondrej Pav, Ivan Rosenberg, Ondrej Simak
  • 2'2'-CYCLIC DINUCLEOTIDES
    Publication number: 20190322697
    Abstract: The present invention relates to 2?2?-cyclic dinucleotides modified with a 2?-phosphonoalkyl bond and derivatives thereof, that can modulate the activity of the STING adaptor protein.
    Type: Application
    Filed: April 4, 2019
    Publication date: October 24, 2019
    Inventors: Gabriel Birkus, Ondrej Pav, Ivan Rosenberg, Ondrej Simak
  • 2'3'-CYCLIC DINUCLEOTIDES
    Publication number: 20190322695
    Abstract: The present disclosure relates to 2?3?-cyclic dinucleotides modified with a 2?- or 3?-phosphonoalkyl bond and derivatives thereof, that can modulate the activity of the STING adaptor protein.
    Type: Application
    Filed: April 4, 2019
    Publication date: October 24, 2019
    Inventors: Gabriel Birkus, Ondrej Pav, Ivan Rosenberg, Ondrej Simak
  • 2'2' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN
    Publication number: 20190185509
    Abstract: Provided herein are 2?2? cyclic phosphonate dinucleotides of formula (J), their pharmaceutically acceptable salts, hydrates or solvates, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, the dinucleotides can be used as adjuvants in vaccines.
    Type: Application
    Filed: December 19, 2018
    Publication date: June 20, 2019
    Inventors: Gabriel Birkus, Ondrej Pav, Tomas Jandusik, Ivan Rosenberg, Radim Nencka
  • 2'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN
    Publication number: 20190185510
    Abstract: The present disclosure relates to 2?3? cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
    Type: Application
    Filed: December 19, 2018
    Publication date: June 20, 2019
    Inventors: Gabriel Birkus, Ondrej Pav, Tomas Jandusik, Ivan Rosenberg, Radim Nencka
  • 3'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN
    Publication number: 20190183917
    Abstract: Provided herein are the 3?3? cyclic phosphonate dinucleotides of general formula J, their pharmaceutically acceptable salts, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
    Type: Application
    Filed: December 19, 2018
    Publication date: June 20, 2019
    Inventors: Gabriel Birkus, Ondrej Pav, Tomas Jandusik, Ivan Rosenberg, Radim Nencka
  • METHODS OF TREATING HEPATITIS B VIRUS
    Publication number: 20180042905
    Abstract: The present invention relates to novel methods of treating Hepatitis B Virus by administering a KDM5 inhibitor.
    Type: Application
    Filed: August 29, 2017
    Publication date: February 15, 2018
    Inventors: Esmeralda Aguayo, Todd Appleby, Gabriel Birkus, Guofeng Cheng, David Dornan, Tetsuya Kobayashi, Christopher Charles Mello, Uli Schmitz, Madeleine Willkom, Mei Yu
  • METHODS OF TREATING HEPATITIS B VIRUS
    Publication number: 20160303095
    Abstract: The present invention relates to novel methods of treating Hepatitis B Virus by administering a KDM5 inhibitor.
    Type: Application
    Filed: April 13, 2016
    Publication date: October 20, 2016
    Inventors: Esmeralda Aguayo, Todd Appleby, Gabriel Birkus, Guofeng Cheng, David Dornan, Tetsuya Kobayashi, Christopher Charles Mello, Uli Schmitz, Madeleine Willkom, Mei Yu
  • Nucleoside analogues containing phosphonate or phosphonamide groups
    Patent number: 8163718
    Abstract: Novel compounds having structure (1) wherein Z, is N or CH to form a purine, Y, R1, R2? and R2 are defined in the specification, are provided for use in the treatment of tumors and the prophylaxis or treatment of viral infections.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: April 24, 2012
    Assignee: Gilead Sciences, Inc.
    Inventors: Gabriel Birkus, Adrian S. Ray, Daniel B. Tumas, William J. Watkins
  • NOVEL COMPOUNDS AND METHODS FOR THERAPY
    Publication number: 20090232768
    Abstract: Novel compounds having structure (1) wherein Z, Y, R1, R2? and R2 are defined in the specification, are provided for use in the treatment of tumors and the prophylaxis or treatment of viral infections.
    Type: Application
    Filed: February 19, 2009
    Publication date: September 17, 2009
    Applicant: Gilead Sciences, Inc.
    Inventors: Gabriel Birkus, Andrian S. Ray, Daniel B. Tumas, William J. Watkins