Patents by Inventor Gabriel De Crozals

Gabriel De Crozals has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems, Apparatus and Kits for Enzymatic Polynucleotide Synthesis
    Publication number: 20230241571
    Abstract: The invention is directed to systems, apparatus and kits for automated synthesis of a plurality of polynucleotides in an array of reaction chambers using a template-free polymerase. In some embodiments, adaptive elements and processes are provided to monitor and control disruption of the synthesis process and fluid movement by enzyme aggregation.
    Type: Application
    Filed: June 14, 2021
    Publication date: August 3, 2023
    Inventors: Carl Martin, Marc Artigue, Sandrine Creton, Gabriel de Crozals, Xavier Godron, Adrian Horgan, Henri Lachaize, John Lucky, Christine Peponnet, Thomas Ybert
  • Diaminophenothiazinium derivatives for labelling biomolecules, method and substrate for labelling oligonucleotides, and oligonucleotides obtained
    Patent number: 9540405
    Abstract: The present invention relates to diaminophenothiazinium derivatives of formula (I); in which R1, R2, R3, R4, R5, R6 and X? are as defined in Claim 1, and also the methods for labelling oligonucleotides using such a derivative, labeling substrates and the oligonucleotides which can be obtained by means of such methods or from such labelling substrates.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: January 10, 2017
    Assignees: UNIVERSITE CLAUDE BERNARD LYON I, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Carole Chaix, Gabriel De Crozals
  • Material for supported synthesis and method for growing oligonucleotides or peptides
    Patent number: 9359396
    Abstract: The invention concerns a material composed of a porous support on which functionalized nanoparticles are grafted by covalent bonding, characterized in that at least part of the nanoparticles grafted by covalent bonding is housed inside surface pores of the support, and in that the support is silica-based and is in the form of porous particles of heterogeneous shape and size, the size of the particles being larger than 1 ?m and preferably within the range of 5 to 200 ?m. The invention further concerns a growth method for oligonucleotides or peptides characterized in that growth is performed on a material formed of a porous support on which functionalized nanoparticles are grafted by covalent bonding, characterized in that at least a part of the nanoparticles grafted by covalent bonding is housed inside surface pores of the support.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: June 7, 2016
    Assignees: UNIVERSITE CLAUDE BERNARD LYON I, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Carole Chaix, Gabriel De Crozals, Carole Farre
  • DIAMINOPHENOTHIAZINIUM DERIVATIVES FOR LABELLING BIOMOLECULES, METHOD AND SUBSTRATE FOR LABELLING OLIGONUCLEOTIDES, AND OLIGONUCLEOTIDES OBTAINED
    Publication number: 20150011712
    Abstract: The present invention relates to diaminophenothiazinium derivatives of formula (I); in which R1, R2, R3, R4, R5, R6 and X? are as defined in Claim 1, and also the methods for labelling oligonucleotides using such a derivative, labeling substrates and the oligonucleotides which can be obtained by means of such methods or from such labelling substrates.
    Type: Application
    Filed: February 21, 2013
    Publication date: January 8, 2015
    Inventors: Carole Chaix, Gabriel De Crozals
  • MATERIAL FOR SUPPORTED SYNTHESIS AND METHOD FOR GROWING OLIGONUCLEOTIDES OR PEPTIDES
    Publication number: 20140135478
    Abstract: The invention concerns a material composed of a porous support on which functionalized nanoparticles are grafted by covalent bonding, characterized in that at least part of the nanoparticles grafted by covalent bonding is housed inside surface pores of the support, and in that the support is silica-based and is in the form of porous particles of heterogeneous shape and size, the size of the particles being larger than 1 ?m and preferably within the range of 5 to 200 ?m. The invention further concerns a growth method for oligonucleotides or peptides characterized in that growth is performed on a material formed of a porous support on which functionalized nanoparticles are grafted by covalent bonding, characterized in that at least a part of the nanoparticles grafted by covalent bonding is housed inside surface pores of the support.
    Type: Application
    Filed: July 10, 2012
    Publication date: May 15, 2014
    Applicant: UNIVERSITE CLAUDE BERNARD LYON I
    Inventors: Carole Chaix, Gabriel De Crozals, Carole Farre