Abstract: The invention relates to terpenoid derivatives, their use in the medicinal applications and compositions containing these derivatives. New generation of compounds possess selective antineurodegenerative properties on neuronal cells and tissues and can be particularly used in the treatment and prophylaxis of neurodegenerative disease, particularly in the treatment and prophylaxis of Parkinson's and Huntington's disease.

Abstract: The invention relates to brassinosteroid-derived cholestane derivatives, their use in the protection of cell damage, injury and cell death and compositions containing these derivatives. New generation of compounds possess also selective antineurodegenerative properties on neuronal cells and tissues and can be particularly used in the treatment and prophylaxis of neurodegenerative disease, particularly in the treatment and prophylaxis of Parkinson's disease.

Abstract: A modular additive manufactured tool assembly includes a perishable tool and a tool holder coupled to the perishable tool. The tool assembly is configured to be coupled to a machine spindle. The tool assembly also includes a spindle connection coupled to the tool holder. The spindle connection is configured to be coupled to a machine spindle. Each of the tool holder and the perishable tool includes a perishable material. Each of the tool holder and the perishable tool is manufactured using an additive manufacturing process.

Abstract: Degrader-antibody conjugates (DACs) are described, comprising anti-TM4SF1 antibodies, and antigen-binding fragments thereof. Degrader molecules as described comprise a ubiquitin E3 ligase binding group (E3LB) and a protein binding group (PB). Linkers may be utilized between the antibodies and the degrader molecules (L1) and between the ubiquitin E3 ligase binding group (E3LB) and the protein binding group (PB) of the degrader molecule (L2). Methods of use of said DACs are also described.

Abstract: A modular additive manufactured tool assembly includes a perishable tool and a tool holder coupled to the perishable tool. The tool assembly is configured to be coupled to a machine spindle. The tool assembly also includes a spindle connection coupled to the tool holder. The spindle connection is configured to be coupled to a machine spindle. Each of the tool holder and the perishable tool includes a perishable material. Each of the tool holder and the perishable tool is manufactured using an additive manufacturing process.

Abstract: A cup plug insertion tool comprises a cylindrical base and a cylindrical collet extending from the base and including at least two longitudinal slots that divide the collet into at least two flexible segments adapted to flex radially inward under force, an annular groove formed adjacent the base, the annular groove adapted to allow the flexible segments to flex radially inward, further wherein, the force necessary to flex the flexible segments radially inward is tunable based on a width and depth of the annular groove, a first section defining a circumferential outer diameter and a circumferential inner diameter, a second section defining a circumferential outer diameter that is larger than the circumferential outer diameter of the first section, a tip positioned at the distal end of the collet, and a chamfer formed between the outer diameter of the first section and the tip.

Abstract: A cup plug insertion tool comprises a cylindrical base and a cylindrical collet extending from the base and including at least two longitudinal slots that divide the collet into at least two flexible segments adapted to flex radially inward under force, an annular groove formed adjacent the base, the annular groove adapted to allow the flexible segments to flex radially inward, further wherein, the force necessary to flex the flexible segments radially inward is tunable based on a width and depth of the annular groove, a first section defining a circumferential outer diameter and a circumferential inner diameter, a second section defining a circumferential outer diameter that is larger than the circumferential outer diameter of the first section, a tip positioned at the distal end of the collet, and a chamfer formed between the outer diameter of the first section and the tip.

Abstract: A gas turbine engine 10 is provided in a fan root to tip pressure ratio, defined as the ratio of the mean total pressure of the flow at the fan exit that subsequently flows through the engine core (P102) to the mean total pressure of the flow at the fan exit that subsequently flows through the bypass duct (P104), is no greater than a certain value. The gas turbine engine 10 may provide improved efficiency when compared with conventional engines, whilst retaining an acceptable flutter margin.

Abstract: A gas turbine engine 10 is provided in which a fan having fan blades in which the camber distribution along the span allows the gas turbine engine to operate with improved efficiency when compared with conventional engines, whilst retaining an acceptable flutter margin.

Abstract: A fan for a gas turbine engine, the fan comprising a first set of fan blades and a second set of fan blades arranged circumferentially around a hub. Each of the fan blades of the first and second set comprises an organic matrix composite body and a leading edge member connected to the body. The leading edge member of the first set of fan blades has a mass less than the leading edge member of the second set of fan blades.

Abstract: The present invention is directed to compositions and methods for inhibiting bloom formation on frozen frosted bakery products, such as cake doughnuts and yeast doughnuts.

Abstract: A bloom-resistant method of freezing and packaging a fresh food product.

Abstract: A fan for a gas turbine engine, the fan comprising a first set of fan blades, each fan blade comprising a root and an axial retention feature provided on the root at a first position, and a second set of fan blades, each fan blade comprising a root and an axial retention feature provided on the root at a second position. Relative to the respective blade on which the respective retention feature is provided, the first position is different to the second position.

Abstract: A boundary layer ingestion engine comprising a fan, the fan comprising a disc and a plurality of blades integrally formed with the disc.

Abstract: A fan blade is provided with an aerofoil portion for which, for cross-sections through the aerofoil portion at radii between 15% and 25% of the blade span from the root radius, the average leading edge thickness is greater than the leading edge thickness at the tip. The geometry of the fan blade may result in a lower susceptibility to flutter.

Abstract: The present invention is directed to compositions and methods for inhibiting bloom formation on frozen frosted bakery products, such as cake doughnuts and yeast doughnuts.

Abstract: A fan blade is provided with an aerofoil portion for which, at radii between 20% and 40% of the blade span, the location of the position of maximum thickness along the camber line is at less than a defined percentage of the total length of the camber line. For all cross-sections through the aerofoil portion at radii greater than 70% of the blade span, the location of the position of maximum thickness along the camber line is at more than a defined percentage of the total length of the camber line. The geometry of the fan blade may result in a lower susceptibility to flutter.

Abstract: The present invention is directed to compositions and methods for inhibiting bloom formation on frozen frosted bakery products, such as cake doughnuts and yeast doughnuts.

Abstract: A mechanical device that has the ability to manage and set explosives cones in the rocks that form the hanging, which can be operated remotely, avoiding the danger of the current state of the art where operators place explosive using bamboo sticks, before detonating them, causing an imbalance in the hanging. The mechanical device also known as cone-holder, is located at the end of an automated and semi autotransportable manipulator arm for releasing hangings.

Abstract: A gas turbine engine and air intake assembly comprises an intake passage extending between an inlet highlight at a first end and an upstream face of a fan at a second end and comprising in flow series an intake lip, a most upstream portion of which defines the intake highlight and a most downstream portion of which defines a throat, a diffuser with sectional area broadening towards the fan; and a straight conditioning duct, arranged immediately upstream of the fan. The camber line of the intake passage intersects the engine main axis at an intersecting point upstream of the fan at an intersecting point and the camber line is parallel to the engine main axis in the straight conditioning duct.