Abstract: The technologies disclosed herein relate to a system and method for transferring markings. The system can include an imaging device for imaging a stained slide and an unstained slide, a display for displaying one or more images of the stained slide and the unstained slide. In various embodiments, the system can include a mechanical stage, such as a scaffold, for positioning or orienting the stained slide with respect to the unstained slide. In various embodiments, the system can be coupled with a first application for aligning the images to enable digital marking of the unstained slide and a second application for digitally marking one or more features and transferring the digital markings into coordinates to be used for further processing, such as for dissection.

Abstract: Some embodiments presented in this disclosure concern an Automated Tissue Dissection (ATD) System. An ATD system is a one stop, and potentially low-cost, system to perform dissections on a substrate from pathologist digital mark or pen mark on the substrate using non-contact and/or mechanical method to extract a Formalin-Fixed Paraffin-Embedded (FFPE) tissue sample with: (a) only the ROI or ROIs as area to be saved; and (b) remove or decompose nucleic acid content in the region of no interest (RONI) and collect all tissue sample from a standard microscope substrate into a specific container.

Abstract: Some embodiments presented in this disclosure concern an Automated Tissue Dissection (ATD) System. An ATD system is a one stop, and potentially low-cost, system to perform dissections on a substrate from pathologist digital mark or pen mark on the substrate using non-contact and/or mechanical method to extract a Formalin-Fixed Paraffin-Embedded (FFPE) tissue sample with: (a) only the ROI or ROIs as area to be saved; and (b) remove or decompose nucleic acid content in the region of no interest (RONI) and collect all tissue sample from a standard microscope substrate into a specific container.

Abstract: A system for automation of sample preparation is disclosed. The system for automation includes a fixture configured to hold a sample and a reader system configured for receiving information pertinent to the sample. In various implementations, the system includes a cutting system configured for removing a portion of the sample. In various implementations, the system includes a cutting system configured for cutting the sample into at least two portions. In various implementations, the system further includes a first bin for collecting a first portion of the at least two portions of the sample. In various implementations, the system also includes a second bin for collecting a second portion of the at least two portions of the sample. In various implementations, the plurality of specimens are arranged linearly along one direction or arranged laterally in a two-dimensional array.