Patents by Inventor Gabriel Lopez

Gabriel Lopez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10874622
    Abstract: Disclosed are nanoparticles for the delivery of a therapeutic agent or a diagnostic agent to a subject that include a chitosan and a polyphosphate, wherein the chitosan nanoparticles are coated with polylactic acid. Methods of delivering a therapeutic agent or a diagnostic agent to a subject for the treatment or prevention of a disease are also disclosed. For example, the treatment of ovarian cancer in a subject by inhibiting the expression of ZNF034 is disclosed.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: December 29, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Burcu Aslan, Gabriel Lopez-Berestein, Anil K. Sood
  • Publication number: 20200355677
    Abstract: Acoustically responsive particles and methods are provided for their use. Methods are provided for making and using tunable, monodisperse acoustically responsive particles and negative contrast acoustic particles, wherein the particles can contain a functional group available for covalent modification.
    Type: Application
    Filed: July 29, 2020
    Publication date: November 12, 2020
    Inventors: Leah M Johnson, Gabriel Lopez, Lu Gao, Charles Wyatt Shields, IV
  • Publication number: 20200069594
    Abstract: Provided herein are lipid-based nanoparticles (e.g., exosomes) having (a) a core comprising a cationic polymer and a therapeutic agent (e.g., a therapeutic protein, an antibody, an inhibitory RNA, and/or a small molecule drug) and (b) a lipid coating comprising an exosomes-derived membrane. Furthermore, the present invention provides methods of producing such nanoparticles as well as methods for use of such lipid-based nanoparticles in therapy.
    Type: Application
    Filed: December 8, 2017
    Publication date: March 5, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventors: Anil K. SOOD, Sherry Y. WU, Gabriel LOPEZ-BERESTEIN
  • Publication number: 20180169029
    Abstract: Disclosed are nanoparticles for the delivery of a therapeutic agent or a diagnostic agent to a subject that include a chitosan and a polyphosphate, wherein the chitosan nanoparticles are coated with polylactic acid. Methods of delivering a therapeutic agent or a diagnostic agent to a subject for the treatment or prevention of a disease are also disclosed. For example, the treatment of ovarian cancer in a subject by inhibiting the expression of ZNF034 is disclosed.
    Type: Application
    Filed: June 23, 2016
    Publication date: June 21, 2018
    Inventors: Burcu ASLAN, Gabriel LOPEZ-BERESTEIN, Anil K. SOOD
  • Publication number: 20180155711
    Abstract: Synthetic auxotrophs with one or more ligand-dependent essential gene functions and methods of production that can be used for biosafety. The ligand-dependent function of an essential gene product can be produced by a series of mutations in the ORF of an essential gene; N, C, or insertional fusions of ligand-binding domains with essential genes or an engineered ligand-dependent intein splicing to alter essential gene function. A positive and/or negative selection can be used to identify auxotrophs from created mutant libraries. The positive selection is performed by growing a mutant library in conditions where growth or viability depends on the function of mutagenized essential genes. The negative selection eliminates constitutively growing cells that do not require a ligand for growth by growing the library in the absence of complementing ligand and in conditions where growing cells are eliminated. Desirable phenotypes are collected after the selections.
    Type: Application
    Filed: November 27, 2017
    Publication date: June 7, 2018
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: John C. Anderson, Gabriel Lopez
  • Publication number: 20160375050
    Abstract: Disclosed are nanoparticles for the delivery of a therapeutic agent or a diagnostic agent to a subject that include a chitosan and a polyphosphate, wherein the weight ratio of the chitosan to the polyphosphate is about 1.0 or greater and the weight ratio of the polyphosphate to the therapeutic agent or diagnostic agent is about 15.0 or less. Also disclosed are nanoparticles that include a chitosan and an inhibitor of enhancer of Zeste homologue 2 (EZH2). Methods of delivering a therapeutic agent or a diagnostic agent to a subject for the treatment or prevention of a disease and methods of predicting prognosis of ovarian cancer in a subject that involve determining the expression and/or function of EZH2 in the subject are also disclosed.
    Type: Application
    Filed: September 13, 2016
    Publication date: December 29, 2016
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Gabriel LOPEZ-BERESTEIN, Eylem G√úVEN, Angela SANGUINO, Anil K. SOOD, Emir Baki DENKBAS
  • Publication number: 20150306077
    Abstract: Provided herein are methods and compositions inter alia for treating diseases, including hyperproliferative diseases, migraine headaches, and depression.
    Type: Application
    Filed: April 28, 2015
    Publication date: October 29, 2015
    Inventors: Bulent Ozpolat, Gabriel Lopez-Berestein, Kevin N. Dalby, Jiney Jose
  • Patent number: 9101664
    Abstract: We describe methods for synthesis and formulations of stable elastomeric negative acoustic contrast particles with controllable compressibility and density. These elastomeric negative acoustic contrast particles have a density/compressibility ratio that is less than that of water and therefore exhibit negative acoustic contrast under acoustic radiation exposure. This negative acoustic contrast allows our elastomeric negative acoustic contrast particles to be acoustically manipulated (e.g. separated) differently from other components (e.g. cells) within an aqueous solution. This disclosure also describes methods for biofunctionalization of the elastomeric negative acoustic contrast particles and as an example their use as platforms for bioassays.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: August 11, 2015
    Inventors: Gabriel Lopez, Gregory Kaduchak
  • Patent number: 9073851
    Abstract: Provided herein are methods and compositions inter alia for treating diseases, including hyperproliferative diseases, migraine headaches, and depression.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: July 7, 2015
    Assignee: Board of Regents, the University of Texas System
    Inventors: Bulent Ozpolat, Gabriel Lopez-Berestein, Kevin N. Dalby, Jiney Jose
  • Patent number: 8895717
    Abstract: The present invention relates to the fields of molecular biology and drug delivery. In certain embodiments, the present invention provides methods for the delivery of a siNA (e.g., a siRNA) to a cell via a neutral (non-charged) liposome. These methods may be used to treat a disease, such as cancer.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: November 25, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Anil K. Sood, Gabriel Lopez-Berestein, Charles N. Landen, Arturo Chavez-Reyes
  • Patent number: 8895321
    Abstract: Device and method for detecting the presence of known or unknown toxic agents in a fluid sample. Targets in the sample are bound to releasable receptors immobilized in a reaction region of a micro- or nano-fluidic device. The receptors are selected based on their affinity for classes of known toxic agents. The receptors are freed and the bound and unbound receptors separated based on differential electrokinetic mobilities while they travel to a detection device.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: November 25, 2014
    Assignee: STC.UNM
    Inventors: Gabriel Lopez, Linnea Ista, Steven RJ Brueck, Aurelio Evangelista Lara, Mangesh Bore
  • Patent number: 8859727
    Abstract: A nanoparticle-polypeptide complex comprising a bioactive polypeptide in association with a nanoparticle, wherein the bioactive polypeptide is modified by the addition of a chemical moiety that facilitates cellular uptake of the protein. The polypeptide can be a protein or a peptide. In some embodiments, the amino acid sequence of the protein or peptide is derived from the amino acid sequence of a tumor suppressor gene product.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: October 14, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Jacki Lin, Ralph Arlinghaus, Tong Sun, Lin Ji, Bulent Ozpolat, Gabriel Lopez-Berestein, Jack A. Roth
  • Patent number: 8830451
    Abstract: An analytical device such as a flow cytometer is provided in which a fluid sample flowing through a channel is focused into multiple, parallel particle streams by an acoustic wave field extending across the channel. Each stream is then presented to an individual detector to allow for simultaneous interrogation of the multiple streams and thus, high-throughput analysis of the fluid sample.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: September 9, 2014
    Assignee: STC.UNM
    Inventors: Steven Wayde Graves, Robert W. Applegate, Jr., Gabriel Lopez, Menake Eranda Piyasena
  • Patent number: 8753570
    Abstract: Novel compounds generally referred to herein as cationic oligomeric phenylene ethynylenes (OPEs), methods of synthesizing OPEs and various uses for the OPEs are described. The compounds can be synthesized in both symmetrical (S-OPE) and non-symmetrical (N-OPE) forms. Suitable uses include sensor and biocidal applications. Reusable structures incorporating the OPEs that are able to capture and release biological species of interest are also described.
    Type: Grant
    Filed: June 26, 2009
    Date of Patent: June 17, 2014
    Assignee: STC.UNM
    Inventors: David Whitten, Yanli Tang, Zhijun Zhou, Linnea Ista, Motokatsu Ogawa, David Keller, Brett Andrzejewski, Gabriel Lopez, Kirk Schanze
  • Patent number: 8734853
    Abstract: Disclosed are high density lipoprotein-nucleic acid particles, wherein the particles include (a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region, wherein the positively-charged region of the polypeptide associates with the nucleic acid component. Also disclosed are pharmaceutical compositions that include a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region. Methods that concern the particles and pharmaceutical compositions of the present invention are also set forth, as well as kits.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: May 27, 2014
    Assignees: University of North Texas Health Science Center at Fort Worth, The Board of Regents, The University of Texas System
    Inventors: Anil K. Sood, Andras G. Lacko, Gabriel Lopez-Berestein, Lingegowda S. Mangala, Walter J. McConathy, Laszlo Prokai, Maya P. Nair
  • Publication number: 20140110258
    Abstract: Device and method for detecting the presence of known or unknown toxic agents in a fluid sample. Targets in the sample are bound to releasable receptors immobilized in a reaction region of a micro- or nano-fluidic device. The receptors are selected based on their affinity for classes of known toxic agents. The receptors are freed and the bound and unbound receptors separated based on differential electrokinetic mobilities while they travel to a detection device.
    Type: Application
    Filed: May 10, 2011
    Publication date: April 24, 2014
    Applicant: STC.UNM
    Inventors: Gabriel Lopez, Linnea Ista, Steven RJ Brueck, Aurelio Evangelista Lara, Mangesh Bore
  • Patent number: 8705804
    Abstract: A method of interpreting specific dipping surfaces in earth formations, namely, fracture and fault planes from borehole images. The method is applicable to borehole images obtained from any borehole imaging tool, regardless of tool physics or acquisition type. The interpretation method provides for detailed description of feature s in order to provide a robust framework for subsequent interpretation work.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: April 22, 2014
    Assignee: Fronterra Integrated Geosciences, LLC
    Inventors: Andrew R. Duncan, Jens Klaus Hustedt, Hermann Josef Homann, Jarret Borell, Ramiro Gabriel Lopez
  • Patent number: 8691363
    Abstract: This invention relates to a nonslip decorative and protective coverings in order to cover and protect distinct surfaces, its composition and the manufacturing process thereof; characterized in that it consists of a foamed cellular film based on dry mixed and calendared suspension resins, defining a smooth textured and decorated upper surface, and a rough lower surface with high adherence; said film consists of a composition of: a) suspension resin of vinyl polychloride and/or copolymer of vinyl chloride; b) plasticizers in order to provide flexibility to the covering; c) other components such as elastomers, Barium/Zinc or tin stabilizers; lubricants, biocides, flame retardants, pigments and charges, in order to facilitate the processing thereof, and d) foaming agents.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: April 8, 2014
    Assignee: PYN, S.A. de C.V.
    Inventor: Gabriel Lopez Montiel
  • Patent number: 8658734
    Abstract: We describe methods for synthesis and formulations of stable elastomeric negative acoustic contrast particles with controllable compressibility and density. These elastomeric negative acoustic contrast particles have a density/compressibility ratio that is less than that of water and therefore exhibit negative acoustic contrast under acoustic radiation exposure. This negative acoustic contrast allows our elastomeric negative acoustic contrast particles to be acoustically manipulated (e.g. separated) differently from other components (e.g. cells) within an aqueous solution. This disclosure also describes methods for biofunctionalization of the elastomeric negative acoustic contrast particles and as an example their use as platforms for bioassays.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: February 25, 2014
    Assignee: STC.UNM
    Inventors: Gabriel Lopez, Nick Carroll, Kevin Cushing, Dimiter N Petsev
  • Publication number: 20130266634
    Abstract: A nanoparticle-polypeptide complex comprising a bioactive polypeptide in association with a nanoparticle, wherein the bioactive polypeptide is modified by the addition of a chemical moiety that facilitates cellular uptake of the protein. The polypeptide can be a protein or a peptide. In some embodiments, the amino acid sequence of the protein or peptide is derived from the amino acid sequence of a tumor suppressor gene product.
    Type: Application
    Filed: December 19, 2012
    Publication date: October 10, 2013
    Inventors: Jacki LIN, Ralph ARLINGHAUS, Tong SUN, Lin JI, Bulent OZPOLAT, Gabriel LOPEZ-BERESTEIN, Jack A. ROTH