Patents by Inventor Gabriel Mintier

Gabriel Mintier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotides encoding two novel human G-protein coupled receptors, HGPRBMY28 and HGPRBMY29, and splice variants thereof
    Publication number: 20080064094
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: August 8, 2007
    Publication date: March 13, 2008
    Inventors: John Feder, Chandra Ramanathan, Gabriel Mintier, David Bol, Donald Hawken
  • Polynucleotides encoding novel PCSK9 variants
    Publication number: 20080008697
    Abstract: The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: June 28, 2007
    Publication date: January 10, 2008
    Inventors: Gabriel Mintier, Jian Chen, John Feder, Bowman Miao, Rex Parker
  • POLYNUCLEOTIDES ENCODING A NOVEL HUMAN G-PROTEIN COUPLED RECEPTOR SPLICE VARIANT, HGPRBMY29SV2
    Publication number: 20070196897
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: March 3, 2005
    Publication date: August 23, 2007
    Inventors: John Feder, Chandra Ramanathan, Gabriel Mintier, David Bol, Donald Hawken
  • Polynucleotide encoding a human relaxin receptor, HGPRBMY5v1
    Patent number: 7189539
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY5v1 and HGPRBMY5v2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY5v1 and HGPRBMY5v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: November 22, 2004
    Date of Patent: March 13, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chandra S. Ramanathan, John N. Feder, Gabriel Mintier, Kelly L. Bennett
  • Human leucine-rich repeat containing protein expressed predominately in small intestine, HLRRSI1
    Publication number: 20070031888
    Abstract: The present invention provides novel polynucleotides encoding HLRRSI1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRSI1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly gastrointestinal diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: October 17, 2006
    Publication date: February 8, 2007
    Inventors: John Feder, Chandra Ramanathan, Gabriel Mintier
  • Novel human leucine-rich repeat domain containing protein HLLRCR-1
    Publication number: 20060292625
    Abstract: The present invention provides novel polynucleotides encoding HLLRCR-1 polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLLRCR-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly nervous system diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: August 28, 2006
    Publication date: December 28, 2006
    Inventors: John Feder, Chandra Ramanathan, Gabriel Mintier
  • Human leucine-rich repeat-containing proteins specifically expressed in the nervous system
    Patent number: 7141381
    Abstract: The present invention describes two newly discovered Human Leucine Rich Repeat (LRR)-containing proteins, HLRRNS-2 and HLRRNS-3, and their encoding polynucleotides. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotides and/or polypeptides of the present invention. In addition, methods involving the new HLRR-containing proteins HLRRNS-2 and HLRRNS-3, or modulators thereof, for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the brain are illustrated.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: November 28, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Gabriel Mintier, Chandra S. Ramanathan
  • Polynucleotide encoding a novel human G-protein coupled receptor variant of the relaxin receptor HGPRBMY5v1, and variants thereof
    Publication number: 20060257918
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY5v1 and HGPRBMY5v2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY5v1 and HGPRBMY5v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: July 13, 2006
    Publication date: November 16, 2006
    Inventors: Chandra Ramanathan, John Feder, Gabriel Mintier
  • Polynucleotides encoding a human leucine-rich repeat domain containing protein, HLLRCR-1
    Patent number: 7129085
    Abstract: The present invention provides novel polynucleotides encoding HLLRCR-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLLRCR-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly nervous system diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: October 31, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Chandra S. Ramanathan, Gabriel Mintier
  • Methods of diagnosing renal tumors by determining the expression level of RNA encoding the HGPRBMY18 polypeptide
    Patent number: 7115375
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, endocrine conditions, neurological conditions, and diseases or disorders related to the pituitary gland, colon, breast, lungs, kidney, and prostate are illustrated.
    Type: Grant
    Filed: January 30, 2004
    Date of Patent: October 3, 2006
    Assignee: Bristol-Myers Squibb
    Inventors: John N. Feder, Gabriel Mintier, Chandra S. Ramanathan
  • Polynucleotide encoding a novel human G-protein coupled receptor, HGPRBMY39
    Publication number: 20060084140
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY39 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY39 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: September 6, 2002
    Publication date: April 20, 2006
    Inventors: Chandra Ramanathan, Shuba Gopal, Gabriel Mintier, John Feder
  • Polynucleotide encoding a novel human G-protein coupled receptor variant of the relaxin receptor, HGPRBMY5v1, and variants thereof
    Publication number: 20050208526
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY5v1 and HGPRBMY5v2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY5v1 and HGPRBMY5v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: November 22, 2004
    Publication date: September 22, 2005
    Inventors: Chandra Ramanathan, John Feder, Gabriel Mintier
  • Human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1
    Publication number: 20050203048
    Abstract: The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRBM1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly immune diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: April 15, 2005
    Publication date: September 15, 2005
    Inventors: John Feder, Chandra Ramanathan, Gabriel Mintier, David Bol, Donald Hawken
  • Novel human G-protein coupled receptor, HGPRBMY29sv1 polypeptides
    Publication number: 20050148016
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: March 2, 2005
    Publication date: July 7, 2005
    Inventors: John Feder, Chandra Ramanathan, Gabriel Mintier, David Bol, Donald Hawken
  • Novel G-protein coupled receptor (GPCR) variants and methods of use thereof
    Publication number: 20040253668
    Abstract: The present invention describes human G-protein coupled receptors (GPCRs) and their encoding polynucleotides. Also described are expression vectors, host cells, antisense molecules, and antibodies associated with the GPCR polynucleotides and/or polypeptides of this invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders or diseases associated with abnormal biological activity of GPCR are described, as are methods for screening for modulators, e.g., agonists or antagonists, of GPCR activity and/or function.
    Type: Application
    Filed: January 22, 2003
    Publication date: December 16, 2004
    Inventors: Chandra S. Ramanathan, Shuba Gopal, Gabriel Mintier, John N. Feder
  • Novel human G-protein coupled receptor, HGPRBMY8, expressed highly in brain
    Publication number: 20040214317
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the brain are illustrated.
    Type: Application
    Filed: November 13, 2003
    Publication date: October 28, 2004
    Inventors: Peter Battaglino, John N. Feder, Gabriel Mintier, Thomas C. Nelson, Chandra S. Ramanathan, Ryan Westphal, Angela M. Cacace, Lauren E. Barber, Donald R. Hawken, Michael G. Kornacker
  • Novel human G-protein coupled receptor, HGPRBMY18, expressed highly in pituitary gland, colon carcinoma, and lung cancer cells
    Publication number: 20040161823
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, endocrine conditions, neurological conditions, and diseases or disorders related to the pituitary gland, colon, breast, lungs, kidney, and prostate are illustrated.
    Type: Application
    Filed: January 30, 2004
    Publication date: August 19, 2004
    Inventors: John N. Feder, Gabriel Mintier, Chandra S. Ramanathan, Donald R. Hawken
  • Novel human G-protein coupled receptor, HGPRBMY9, expressed highly in brain and testes
    Publication number: 20040147732
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, urological conditions, and diseases or disorders related to the brain and testes are illustrated. Additional methods for treating, diagnosing, preventing, and screening for disorders associated with Alzheimer's disease, proliferative lung disorders, and disorders associated with aberrant NFkB and/or E-selectin expression and/or function are illustrated.
    Type: Application
    Filed: October 7, 2003
    Publication date: July 29, 2004
    Inventors: John N. Feder, Gabriel Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela M. Cacace, Kelly L. Bennett
  • Polynucleotide encoding novel human G-protein coupled receptors, and splice variants thereof
    Publication number: 20040018976
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY30_1, HGPRBMY30_2, HGPRBMY30_3, HGPRBMY41_1, HGPRBMY41_2, HGPRBMY41_3, HGPRBMY42, HGPRBMY42_1, HGPRBMY43, and/or HGPRBMY44 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY30_1, HGPRBMY30_2, HGPRBMY30_3, HGPRBMY41_1, HGPRBMY41_2 HGPRBMY41_3, HGPRBMY42, HGPRBMY42_1, HGPRBMY43, and/or HGPRBMY44 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: May 13, 2003
    Publication date: January 29, 2004
    Inventors: John N. Feder, Gabriel Mintier, Chandra S. Ramanathan
  • Polynucleotide encoding a novel human G-protein coupled receptor, HGPRBMY40_2
    Publication number: 20030232359
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY40_2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY40_2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: March 18, 2003
    Publication date: December 18, 2003
    Inventors: Chandra S. Ramanathan, Gabriel Mintier, Shuba Gopal, John N. Feder