Patents by Inventor Gabriel Robbie

Gabriel Robbie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES USING TRANSTHYRETIN (TTR) iRNA COMPOSITIONS
    Publication number: 20240100080
    Abstract: The present invention provides methods for treating or preventing TTR-associated diseases using RNAi agents, e.g., double stranded RNAi agents, that target the transthyretin (TTR) gene.
    Type: Application
    Filed: April 12, 2023
    Publication date: March 28, 2024
    Inventors: Amy Chan, John Vest, Gabriel Robbie, Husain Z. Attarwala, Varun Goel
  • METHODS AND COMPOSITIONS FOR TREATING PRIMARY HYPEROXALURIA
    Publication number: 20230392155
    Abstract: The present invention provides methods and compositions for treating a pediatric subject having primary hyperoxaluria and methods for preventing at least one symptom in a pediatric subject having primary hyperoxaluria. The methods include administering to the subject a therapeutically effective amount or a prophylactically effective amount of an RNAi agent, e.g., double-stranded RNAi agent, targeting HAO1.
    Type: Application
    Filed: April 19, 2023
    Publication date: December 7, 2023
    Inventors: Gabriel Robbie, Varun Goel
  • METHOD OF TREATING INFLUENZA A
    Publication number: 20230181735
    Abstract: Provided herein are methods for treating, reducing or preventing influenza A virus infection in a patient, as well as compositions and articles of manufacture for treating, reducing or preventing influenza A virus infection in a patient.
    Type: Application
    Filed: December 9, 2022
    Publication date: June 15, 2023
    Inventors: Nicole KALLEWAARD-LELAY, Raburn MALLORY, Gabriel ROBBIE, Song REN
  • Method of treating influenza A
    Patent number: 11547756
    Abstract: Provided herein are methods for treating, reducing or preventing influenza A virus infection in a patient, as well as compositions and articles of manufacture for treating, reducing or preventing influenza A virus infection in a patient.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: January 10, 2023
    Assignee: MEDIMMUNE, LLC
    Inventors: Nicole Kallewaard-Lelay, Raburn Mallory, Gabriel Robbie, Song Ren
  • METHODS AND COMPOSITIONS FOR TREATING A SERPINC1-ASSOCIATED DISORDER
    Publication number: 20220017902
    Abstract: The invention relates to iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and to treat subjects having a Serpinc1-associated disease, e.g., a bleeding disorder, such as a hemophilia.
    Type: Application
    Filed: July 14, 2021
    Publication date: January 20, 2022
    Applicant: Genzyme Corporation
    Inventors: Akin Akinc, Benny Sorensen, Pushkal Garg, Gabriel Robbie
  • Methods and compositions for treating a Serpinc1-associated disorder
    Patent number: 11091759
    Abstract: The invention relates to iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and to treat subjects having a Serpinc1-associated disease, e.g., a bleeding disorder, such as a hemophilia.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: August 17, 2021
    Assignee: Genzyme Corporation
    Inventors: Akin Akinc, Benny Sorensen, Pushkal Garg, Gabriel Robbie
  • COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
    Publication number: 20210171946
    Abstract: The invention relates to methods for treating subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria, using iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and anti-C5 antibodies, e.g., eculizumab.
    Type: Application
    Filed: October 14, 2020
    Publication date: June 10, 2021
    Inventors: Nader Najafian, Jae Kim, Mustafa Varoglu, Gabriel Robbie
  • METHOD OF TREATING INFLUENZA A
    Publication number: 20200397899
    Abstract: Provided herein are methods for treating, reducing or preventing influenza A virus infection in a patient, as well as compositions and articles of manufacture for treating, reducing or preventing influenza A virus infection in a patient.
    Type: Application
    Filed: August 4, 2020
    Publication date: December 24, 2020
    Inventors: Nicole Kallewaard-Lelay, Raburn Mallory, Gabriel Robbie, Song Ren
  • METHODS FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES USING TRANSTHYRETIN (TTR) iRNA COMPOSITIONS
    Publication number: 20190350962
    Abstract: The present invention provides methods for treating or preventing TTR-associated diseases using RNAi agents, e.g., double stranded RNAi agents, that target the transthyretin (TTR) gene.
    Type: Application
    Filed: December 15, 2017
    Publication date: November 21, 2019
    Inventors: Amy Chan, John Vest, Gabriel Robbie, Husain Z. Attarwala, Varun Goel
  • COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
    Publication number: 20190256845
    Abstract: The invention relates to methods for treating subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria, using iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and anti-C5 antibodies, e.g., eculizumab.
    Type: Application
    Filed: June 9, 2017
    Publication date: August 22, 2019
    Inventors: Nader Najafian, Jae Kim, Mustafa Varoglu, Gabriel Robbie
  • METHODS OF USING ANTI-ALPHA TOXIN ANTIBODY
    Publication number: 20190077851
    Abstract: Provided herein are methods of preventing and treating a bacterial infection, e.g., a Staphylococcus aureus infection, in a patient, comprising administering to the patient an effective amount of an anti-alpha toxin antibody or an antigen-binding fragment thereof, such as MEDI4893.
    Type: Application
    Filed: October 27, 2016
    Publication date: March 14, 2019
    Inventors: Hasan JAFRI, Terramika BELLAMY, Susan COLBERT, Brian BISHOP, Gabriel ROBBIE, Mark ESSER, Bret SELLMAN, Kathryn JENSEN, Kellie RYAN, Xiang-Qing YU, Bruno FRANCOIS
  • METHOD OF TREATING INFLUENZA A
    Publication number: 20190015509
    Abstract: Provided herein are methods for treating, reducing or preventing influenza A virus infection in a patient, as well as compositions and articles of manufacture for treating, reducing or preventing influenza A virus infection in a patient.
    Type: Application
    Filed: January 12, 2017
    Publication date: January 17, 2019
    Inventors: Nicole KALLEWAARD-LELAY, Raburn MALLORY, Gabriel ROBBIE, Song REN
  • METHODS AND COMPOSITIONS FOR TREATING A SERPINC1-ASSOCIATED DISORDER
    Publication number: 20170159053
    Abstract: The invention relates to iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and to treat subjects having a Serpinc1-associated disease, e.g., a bleeding disorder, such as a hemophilia.
    Type: Application
    Filed: December 7, 2016
    Publication date: June 8, 2017
    Inventors: Akin Akinc, Benny Sorensen, Pushkal Garg, Gabriel Robbie