Abstract: Systems and methods for model-driven system integration on a ventilator comprise a modeled exhalation flow. Ventilator flow sensors contain components that are easily damaged or impacted and have high rates of failure. Knowledge failure frequency and type may help determine when to replace, clean, or calibrate a flow sensor. A modeled exhalation flow may be trained for a ventilator. Additionally, the modeled exhalation flow may be compared to a flow sensor flow to determine a specific failure. Additionally or alternatively, the modeled exhalation flow may supplement, weight, or replace a faulty flow sensor measurement. These systems and methods may assist in identifying an inaccurate flow sensor measurement and/or providing a more accurate modeled flow estimate, thus increasing accuracy in patient-ventilator interactions.

Abstract: A hybrid single-limb patient circuit coupled to an inspiratory port and an expiratory port of a ventilator. The hybrid single-limb patient circuit may include a check valve positioned to direct breathing gases supplied from the inspiratory port in a single direction; a manifold pneumatically coupled to the check valve; a dual-purpose single limb, pneumatically coupled to the manifold and the non-invasive patient interface, to carry breathing gases to the non-invasive patient interface and carry exhaled gases from the non-invasive patient interface; and an exhalation tubing segment, pneumatically coupled to the manifold and the expiratory port, to carry the exhaled gases from the manifold to the expiratory port.

Abstract: A loudspeaker system can have first and second loudspeakers selectively operable in a single-channel mode or in a multi-channel mode. In the single-channel mode, the first and the second loudspeakers are configured to simultaneously reproduce a substantially identical signal. In the multi-channel mode, the first loudspeaker reproduces a first-channel signal and the second loudspeaker reproduces a second-channel signal. The first-channel signal and the second-channel signal can constitute respective portions of a multi-channel signal. Such loudspeaker systems can also have a mode selector configured to select one of the single-channel mode and the multi-channel mode. In some embodiments, such selection can occur in response to one or more detected proximities of another loudspeaker system. Multi-zone loudspeaker systems are also disclosed.

Abstract: Techniques are disclosed for managing the connection assignments of a plurality of accessory devices to one or more hub devices. In one example, a user device acting as a leader device receives an assignment request from an accessory device. The user device may obtain information corresponding to hub attributes from the one or more hub devices. The user device may also obtain accessory traits from the accessory device. The user device can compare the accessory traits with the hub attributes to determine a connection score for each hub device. The user device can then assign the accessory device to the hub device with the highest connection score.

Abstract: Systems and methods for model-driven system integration on a ventilator comprise a modeled exhalation flow. Ventilator flow sensors contain components that are easily damaged or impacted and have high rates of failure. Knowledge failure frequency and type may help determine when to replace, clean, or calibrate a flow sensor. A modeled exhalation flow may be trained for a ventilator. Additionally, the modeled exhalation flow may be compared to a flow sensor flow to determine a specific failure. Additionally or alternatively, the modeled exhalation flow may supplement, weight, or replace a faulty flow sensor measurement. These systems and methods may assist in identifying an inaccurate flow sensor measurement and/or providing a more accurate modeled flow estimate, thus increasing accuracy in patient-ventilator interactions.

Abstract: In some aspects, the present disclosure provides methods for identifying a disease in an epithelial tissue of a subject. Methods for identifying a disease in an epithelial tissue comprise the generation of a depth profile of the epithelial tissue using signals generated from the tissue by pulses of light directed towards a surface of the epithelial tissue. In some aspects, the present disclosure provides apparatuses consistent with the methods herein.

Abstract: Systems and methods for lung-protective ventilation are disclosed. In examples, volume-targeted, pressure-controlled ventilation may deliver mandatory breaths to a patient without a rise time setting. Inputs into the ventilation may include a peak inspiratory flow value (Qpeak) and a target tidal volume (VT,set). Respiratory parameters of the patient may be determined based on test breaths. The inputs and the respiratory parameters may be used to calculate a target inspiratory pressure (Pi) and target rise time constant (?). Breaths may then be delivered based on the calculated target inspiratory pressure and target rise time constant. Mechanical power delivered to the patient may also be monitored as an additional measure for patient lung protection.

Abstract: Systems and methods for fluid delivery into a ventilation system are disclosed. In an example, the technology relates to a fluid delivery system for delivery of aerosolized liquid. The fluid delivery system includes an injection tip having a set of orifices configured to aerosolize a liquid having certain properties. The injection tip may be couplable with components of a breathing circuit. For example, the injection tip may be couplable with components at or below a wye component (e.g., at a wye component or between the wye component and a patient), such as at the wye component or at an endotracheal tube multi-port connector. Alternatively, the injection tip may be integrated into a breathing circuit, such as at an endotracheal tube connector or at an endotracheal tube.

Abstract: The present disclosure provides methods and apparatuses for identifying and/or analyzing a muscle tissue of a subject. An apparatus for identifying and/or analyzing muscle tissue of the present disclosure may comprise an optical element comprising an excitation probe and a collection probe. A method for identifying or analyzing muscle tissue of the present disclosure may comprise the generation of images of a muscle tissue using signals generated from the tissue by a beam of light directed towards the muscle tissue from the excitation probe and collected by the collection probe. Signals collected by the collection probe may include forward second harmonic generation signals.

Abstract: A ventilation system that includes a pressure source, a pneumatic path configured to receive gas from the pressure source and comprising a first pneumatic component coupled to a second pneumatic component. The first pneumatic component includes a first electrical conductor including a first electrical component having a first electrical characteristic. The second pneumatic component comprises a second electrical conductor including a second electrical component having a second electrical characteristic. The first electrical conductor is electrically connected with the second electrical conductor in an electric path. The system performs operations including determining a continuity of the electrical path; displaying a notification regarding the continuity of the electrical path; detecting the unique electrical characteristic of the electric path; and determining a pneumatic characteristic of the pneumatic path.

Abstract: Systems and methods for automatically improving patient-ventilator synchronization, including a method, performed by a ventilator, for automatic synchrony adjustment in medical ventilation. The method may include delivering positive pressure during a first inhalation phase; cycling to a first exhalation phase at an end of the first inhalation phase according to a cycling sensitivity; and at an end of the first exhalation phase, triggering a second inhalation phase. The method may also include during at least one of the first exhalation phase or the second inhalation phase, detecting a cycling-related asynchrony event; in response to the detecting, automatically adjusting the cycling sensitivity without additional user input; delivering positive pressure during the second inhalation phase; and cycling from the second inhalation phase to a second exhalation phase according to the adjusted cycling sensitivity.

Abstract: Systems and methods for novel ventilation that allows the patient to trigger or initiate the delivery of a breath are provided. Further, systems and methods for triggering ventilation based on signal distortion of a monitored patient parameter are provided.

Abstract: Systems and methods for novel ventilation that allows the patient to trigger or initiate the delivery of a breath are provided. Further, systems and methods for triggering ventilation based on signal distortion of a monitored patient parameter are provided.

Abstract: Techniques are disclosed for managing the connection assignments of a plurality of accessory devices to one or more hub devices. In one example, a user device acting as a leader device receives an assignment request from an accessory device. The user device may obtain information corresponding to hub attributes from the one or more hub devices. The user device may also obtain accessory traits from the accessory device. The user device can compare the accessory traits with the hub attributes to determine a connection score for each hub device. The user device can then assign the accessory device to the hub device with the highest connection score.

Abstract: Techniques are disclosed for connecting third-party accessories to a cellular-capable device to participate in a telephone call. In one example, a user can voice a request to make a call to an accessory device. The accessory device can transmit the request to a controller device. Upon processing the request, the controller device can identify an appropriate cellular-capable device and instruct the cellular-capable device to place the requested call. The controller device can also instruct the cellular-capable device to establish an audio connection with the accessory device to relay the call audio. In another example, the controller device can listen for a word spoken at the accessory device indicating the end of the call. Upon receiving the end of call word, the controller device can instruct the cellular-capable device to terminate the call. While in the listening state, the controller device may continue processing user requests received at other accessory devices.

Abstract: Techniques are disclosed for coordinating interactions between a user device and a plurality of accessory devices. In one example, a user device receives information identifying one or more accessory devices in communication with the user device. The user device may implement accessory interaction instances for each of the identified accessories. A first accessory interaction instance can be associated with a first accessory among the identified accessories and receive a first audio input from the first accessory corresponding to a user request. The first accessory interaction instance can process a portion of the received audio input and receive a first response from a server computer. The user device may then transmit the first response to the first accessory device.

Abstract: In some aspects, the present disclosure provides methods for identifying a disease in an epithelial tissue of a subject. Methods for identifying a disease in an epithelial tissue comprise the generation of a depth profile of the epithelial tissue using signals generated from the tissue by pulses of light directed towards a surface of the epithelial tissue. In some aspects, the present disclosure provides apparatuses consistent with the methods herein.

Abstract: Systems and methods for increasing accuracy of the fraction of inspired oxygen (FiO2) in delivered breathing gases. In an aspect, the technology relates to a blower-based ventilation system. The system includes a blower; an oxygen flow valve; a processor; and memory storing instructions that, when executed by the processor causes the system to perform a set of operations. The set of operations include, based on a target oxygen concentration level, determining a target ambient air flow rate and a target oxygen flow rate; measuring a flow rate of ambient air generated by a blower; measuring a flow rate of oxygen from an oxygen flow valve; determining a synchronization error; and based on the synchronization error, adjusting operation of at least one of the blower or the oxygen flow valve.

Abstract: A humidifier, for a ventilation system, that includes an atomizer configured to deliver water droplets into a flow of breathing gases and a heating element configured to vaporize the water droplets emitted from the atomizer. The humidifier may be configured to set a target inhalation gas temperature based on internal temperature of a patient. Further, based on inspiratory flow and humidity data about breathing gases upstream of the atomizer of the humidifier, the humidifier may calculate and deliver an amount of water in one or more bursts of atomized water. Based on the target inhalation gas temperature, the humidifier may control a temperature of the heating element.

Abstract: Provided herein are methods, devices, and systems that may improve optical resolution when imaging through a thickness of samples. A method for generating a depth profile of a tissue of a subject may comprise using an optical probe to transmit an excitation light beam from a light source towards a surface of the tissue; using one or more focusing units in the optical probe to simultaneously adjust a depth and a position of a focal point of the excitation light beam along a scanning path; detecting at least a subset of the signals generated upon contacting the tissue with the excitation light beam; and using one or more computer processors programmed to process the at least the subset of the signals to generate the depth profile of the tissue.