Patents by Inventor Gabriel Simon
Gabriel Simon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12274879Abstract: An arrangement for reducing intraocular pressure includes a pulse signal source, a probe coupling, and at least one electrode. The probe coupling is configured to be supported on a portion of a living eye. The electrodes are supported on the probe coupling. The electrodes are operably coupled to receive a pulse signal from the pulse signal source.Type: GrantFiled: July 6, 2023Date of Patent: April 15, 2025Assignees: Purdue Research Foundation, The Jackson LaboratoryInventors: Pedro Irazoqui, Simon John, Alex Kokini, Adam Willats, Alexander Chelminski, Matt Matuscak, Gabriel Simon
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Publication number: 20250050122Abstract: Systems and methods for wireless stimulation of biological tissue (e.g. nerves, muscle tissue, etc.) and, in one exemplary implementation, to therapy for glaucoma based on the wireless administration of energy to the eye of a mammalian subject (e.g. human, rodent, etc.) to reduce an elevated intraocular pressure (IOP) involving the use of a multi-coil wireless power transfer assembly. The multi-coil wireless power transfer assembly may be used alone or in combination with a stimulation coil that can be implanted in the eye of a mammalian subject or within a contact lens worn by a mammalian subject.Type: ApplicationFiled: October 29, 2024Publication date: February 13, 2025Inventors: Pedro P. Irazoqui, Gabriel Simon, Gabriel O. Albors, Jack Williams, Quan Yuan, Zhi Wang, Curtis Slaubaugh
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Publication number: 20250001176Abstract: An improved stimulus coil for use in wireless stimulation of biological tissue (e.g., nerves, muscle tissue, etc.) and, in one exemplary implementation, to glaucoma therapy based on the wireless administration of energy to the eye of a mammalian subject (e.g., human, rodent, etc.) to reduce an elevated intraocular pressure (IOP) involving the use of an improved stimulus coil. The improved stimulus coil may be implanted in the eye of a mammalian subject or positioned on the exterior of the eye, such as (by way of example) by being disposed within a contact lens worn by a mammalian subject.Type: ApplicationFiled: July 1, 2024Publication date: January 2, 2025Inventors: Pedro P. Irazoqui, Gabriel Simon, Gabriel O. Albors, Jack Williams, Quan Yuan
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Patent number: 12161877Abstract: Systems and methods for wireless stimulation of biological tissue (e.g. nerves, muscle tissue, etc.) and, in one exemplary implementation, to therapy for glaucoma based on the wireless administration of energy to the eye of a mammalian subject (e.g. human, rodent, etc.) to reduce an elevated intraocular pressure (IOP) involving the use of a multi-coil wireless power transfer assembly. The multi-coil wireless power transfer assembly may be used alone or in combination with a stimulation coil that can be implanted in the eye of a mammalian subject or within a contact lens worn by a mammalian subject.Type: GrantFiled: December 19, 2022Date of Patent: December 10, 2024Assignee: Purdue Research FoundationInventors: Pedro P. Irazoqui, Gabriel Simon, Gabriel O. Albors, Jack Williams, Quan Yuan, Zhi Wang, Curtis Slaubaugh
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Publication number: 20240336614Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.Type: ApplicationFiled: October 16, 2023Publication date: October 10, 2024Inventors: Upul Keerthi BANDARAGE, Cavan McKeon BLIGH, Diane BOUCHER, Michael John BOYD, Michael Aaron BRODNEY, Michael Philip CLARK, Veronique DAMAGNEZ, Lev Tyler Dewey FANNING, Robert Francis FIMOGNARI, Gabrielle Simone FLEMING, Kevin James GAGNON, Pedro Manuel GARCIA BARRANTES, Robert Daniel GIACOMETTI, Simon GIROUX, Ronald Lee GREY, JR., Samantha GUIDO, Amy Beth HALL, Sarah Carol HOOD, Dennis James HURLEY, Mac Arthur JOHNSON, JR., Peter Jones, Sarathy KESAVAN, Mei-Hsiu LAI, Siying LIU, Adam LOOKER, Brad MAXWELL, John Patrick MAXWELL, Ales MEDEK, Philippe Marcel NUHANT, Kirk Alan OVERHOFF, Setu RODAY, Stefanie ROEPER, Steven M. RONKIN, Rupa SAWANT, Yi SHI, Muna SHRESTHA, Marisa SPOSATO, Kathy STAVROPOULOS, Rebecca Jane SWETT, Timothy Lewis TAPLEY, Qing TANG, Stephen THOMSON, Jinwang XU, Mariam ZAKY, Kevin Michael COTTRELL
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Patent number: 12023497Abstract: An improved stimulus coil for use in wireless stimulation of biological tissue (e.g., nerves, muscle tissue, etc.) and, in one exemplary implementation, to glaucoma therapy based on the wireless administration of energy to the eye of a mammalian subject (e.g., human, rodent, etc.) to reduce an elevated intraocular pressure (IOP) involving the use of an improved stimulus coil. The improved stimulus coil may be implanted in the eye of a mammalian subject or positioned on the exterior of the eye, such as (by way of example) by being disposed within a contact lens worn by a mammalian subject.Type: GrantFiled: December 6, 2021Date of Patent: July 2, 2024Assignee: Purdue Research FoundationInventors: Pedro P. Irazoqui, Gabriel Simon, Gabriel O. Albors, Jack Williams, Quan Yuan
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Publication number: 20240123078Abstract: Disclosed herein are methods, pharmaceutical compositions for modulating T cell proteins. Also disclosed herein are methods, pharmaceutical compositions, and vaccines for modulating an immune response.Type: ApplicationFiled: October 15, 2020Publication date: April 18, 2024Inventors: Matthew PATRICELLI, Gabriel SIMON
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Patent number: 11884672Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.Type: GrantFiled: May 13, 2020Date of Patent: January 30, 2024Assignee: Vertex Pharmaceuticals IncorporatedInventors: Upul Keerthi Bandarage, Cavan McKeon Bligh, Diane Boucher, Michael John Boyd, Michael Aaron Brodney, Michael Philip Clark, Veronique Damagnez, Lev Tyler Dewey Fanning, Robert Francis Fimognari, Gabrielle Simone Fleming, Kevin James Gagnon, Pedro Manuel Garcia Barrantes, Robert Daniel Giacometti, Simon Giroux, Ronald Lee Grey, Jr., Samantha Guido, Amy Beth Hall, Sarah Carol Hood, Dennis James Hurley, Mac Arthur Johnson, Jr., Peter Jones, Sarathy Kesavan, Mei-Hsiu Lai, Siying Liu, Adam Looker, Brad Maxwell, John Patrick Maxwell, Ales Medek, Philippe Marcel Nuhant, Kirk Alan Overhoff, Setu Roday, Stefanie Roeper, Steven M. Ronkin, Rupa Sawant, Yi Shi, Muna Shrestha, Marisa Sposato, Kathy Stavropoulos, Rebecca Jane Swett, Timothy Lewis Tapley, Qing Tang, Stephen Thomson, Jinwang Xu, Mariam Zaky, Kevin Michael Cottrell
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Publication number: 20230381516Abstract: An arrangement for reducing intraocular pressure includes a pulse signal source, a probe coupling, and at least one electrode. The probe coupling is configured to be supported on a portion of a living eye. The electrodes are supported on the probe coupling. The electrodes are operably coupled to receive a pulse signal from the pulse signal source.Type: ApplicationFiled: July 6, 2023Publication date: November 30, 2023Inventors: Pedro Irazoqui, Simon John, Alex Kokini, Adam Willats, Alexander Chelminski, Matt Matuscak, Gabriel Simon
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Publication number: 20230339915Abstract: Novel compounds, compositions, and methods of using and preparing the same, which maybe useful for treating alpha-1 antitrypsin deficiency (AATD).Type: ApplicationFiled: April 2, 2021Publication date: October 26, 2023Inventors: Simon GIROUX, Michael Philip CLARK, Qing TANG, Philippe Marcel NUHANT, Peter JONES, David MESSERSMITH, Upul Keerthi BANDARAGE, Kevin Michael COTTRELL, Michael Aaron BRODNEY, Gabrielle Simone FLEMING, Jian WANG, Jinwang XU, Kevin Brett DANIEL, Michael John BOYD, Mark A. MORRIS, Nathan D. WAAL, Philip Noel COLLIER, Sarathy KESAVAN, Steven M. RONKIN, Hongbo DENG, Diane Marie BOUCHER, Lev T.D. FANNING, Amy B. HALL, Dennis James HURLEY, Mac Arthur JOHNSON, Jr., John Patrick MAXWELL, Rebecca Jane SWETT, Timothy Lewis TAPLEY, Stephen A. THOMSON, Veronique DAMAGNEZ
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Patent number: 11730961Abstract: An arrangement for reducing intraocular pressure includes a pulse signal source, a probe coupling, and at least one electrode. The probe coupling is configured to be supported on a portion of a living eye. The electrodes are supported on the probe coupling. The electrodes are operably coupled to receive a pulse signal from the pulse signal source.Type: GrantFiled: December 16, 2020Date of Patent: August 22, 2023Assignees: Purdue Research Foundation, The Jackson LaboratoryInventors: Pedro Irazoqui, Simon John, Alex Kokini, Adam Willats, Alexander Chelminski, Matt Matuscak, Gabriel Simon
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Publication number: 20230159502Abstract: Indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).Type: ApplicationFiled: April 2, 2021Publication date: May 25, 2023Inventors: Simon GIROUX, Michael Philip CLARK, Michael Aaron BRODNEY, Philippe Marcel NUHANT, Emily Elizabeth ALLEN, Robert Francis FIMOGNARI, Jr., Mariam ZAKY, Michael John BOYD, David D. DEININGER, Hu ZHANG, Hongbo DENG, Philip Noel COLLIER, Brad MAXWELL, Nathan D. WAAL, Steven M. RONKIN, Jian WANG, Qing TANG, Gabrielle Simone FLEMING, Peter JONES, Diane Marie BOUCHER, Lev T.D. FANNING, Amy B. HALL, Dennis James HURLEY, Mac Arthur JOHNSON, Jr., John Patrick MAXWELL, Rebecca Jane SWETT, Timothy Lewis TAPLEY, Stephen A. THOMSON, Veronique DAMAGNEZ, Kevin Michael COTTRELL, Upul Keerthi BANDARAGE
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Publication number: 20230119048Abstract: Systems and methods for wireless stimulation of biological tissue (e.g. nerves, muscle tissue, etc.) and, in one exemplary implementation, to therapy for glaucoma based on the wireless administration of energy to the eye of a mammalian subject (e.g. human, rodent, etc.) to reduce an elevated intraocular pressure (IOP) involving the use of a multi-coil wireless power transfer assembly. The multi-coil wireless power transfer assembly may be used alone or in combination with a stimulation coil that can be implanted in the eye of a mammalian subject or within a contact lens worn by a mammalian subject.Type: ApplicationFiled: December 19, 2022Publication date: April 20, 2023Inventors: Pedro P. Irazoqui, Gabriel Simon, Gabriel O. Albors, Jack Williams, Quan Yuan, Zhi Wang, Curtis Slaubaugh
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Patent number: 11529528Abstract: Systems and methods for wireless stimulation of biological tissue (e.g. nerves, muscle tissue, etc.) and, in one exemplary implementation, to therapy for glaucoma based on the wireless administration of energy to the eye of a mammalian subject (e.g. human, rodent, etc.) to reduce an elevated intraocular pressure (IOP) involving the use of a multi-coil wireless power transfer assembly. The multi-coil wireless power transfer assembly may be used alone or in combination with a stimulation coil that can be implanted in the eye of a mammalian subject or within a contact lens worn by a mammalian subject.Type: GrantFiled: August 6, 2018Date of Patent: December 20, 2022Assignee: Purdue Research FoundationInventors: Pedro P. Irazoqui, Gabriel Simon, Gabriel Omar Albors, Jack Williams, Quan Yuan, Zhi Wang, Curtis Slaubaugh
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Publication number: 20220088385Abstract: An improved stimulus coil for use in wireless stimulation of biological tissue (e.g., nerves, muscle tissue, etc.) and, in one exemplary implementation, to glaucoma therapy based on the wireless administration of energy to the eye of a mammalian subject (e.g., human, rodent, etc.) to reduce an elevated intraocular pressure (IOP) involving the use of an improved stimulus coil. The improved stimulus coil may be implanted in the eye of a mammalian subject or positioned on the exterior of the eye, such as (by way of example) by being disposed within a contact lens worn by a mammalian subject.Type: ApplicationFiled: December 6, 2021Publication date: March 24, 2022Inventors: Pedro P. Irazoqui, Gabriel Simon, Gabriel O. Albors, Jack Williams, Quan Yuan
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Patent number: 11191962Abstract: An improved stimulus coil for use in wireless stimulation of biological tissue (e.g., nerves, muscle tissue, etc.) and, in one exemplary implementation, to glaucoma therapy based on the wireless administration of energy to the eye of a mammalian subject (e.g., human, rodent, etc.) to reduce an elevated intraocular pressure (IOP) involving the use of an improved stimulus coil. The improved stimulus coil may be implanted in the eye of a mammalian subject or positioned on the exterior of the eye, such as (by way of example) by being disposed within a contact lens worn by a mammalian subject.Type: GrantFiled: March 12, 2019Date of Patent: December 7, 2021Assignee: Purdue Research FoundationInventors: Pedro P. Irazoqui, Gabriel Simon, Gabriel O. Albors, Jack Williams, Quan Yuan
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Patent number: 11191961Abstract: Systems and methods for wireless glaucoma therapy involving the administration of energy to an eye of a mammalian subject in a therapeutically effective amount sufficient to (1) decrease the inflow of aqueous humor into the anterior segment of the eye and/or (2) increase the outflow of aqueous humor from the anterior segment of the eye. Systems and methods involve the use of wireless power transfer (WPT) and optional stimulus coils adapted to be positioned on and/or within the eye. A Frensel lens is also disclosed for vision correction, which may be used alone or in combination with the system for wireless glaucoma therapy.Type: GrantFiled: June 22, 2017Date of Patent: December 7, 2021Assignee: Purdue Research FoundationInventors: Pedro Irazoqui, Gabriel Simon, Gabriel Omar Albors, Jack Williams, Zhi Wang, Quan Yuan, Curtis Slaubaugh, Hansraj Singh Bhamra
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Publication number: 20210346698Abstract: An arrangement for reducing intraocular pressure includes a pulse signal source, a probe coupling, and at least one electrode. The probe coupling is configured to be supported on a portion of a living eye. The electrodes are supported on the probe coupling. The electrodes are operably coupled to receive a pulse signal from the pulse signal source.Type: ApplicationFiled: December 16, 2020Publication date: November 11, 2021Inventors: Pedro Irazoqui, Simon John, Alex Kokini, Adam Willats, Alexander Chelminski, Matt Matuscak, Gabriel Simon
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Patent number: 10870004Abstract: An arrangement for reducing intraocular pressure includes a pulse signal source, a probe coupling, and at least one electrode. The probe coupling is configured to be supported on a portion of a living eye. The electrodes are supported on the probe coupling. The electrodes are operably coupled to receive a pulse signal from the pulse signal source.Type: GrantFiled: August 10, 2018Date of Patent: December 22, 2020Assignees: Purdue Research Foundation, The Jackson LaboratoryInventors: Pedro Irazoqui, Simon John, Alex Kokini, Adam Willats, Alexander Chelminski, Matt Matuscak, Gabriel Simon
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Publication number: 20200368064Abstract: Systems and methods for wireless stimulation of biological tissue (e.g. nerves, muscle tissue, etc.) and, in one exemplary implementation, to therapy for glaucoma based on the wireless administration of energy to the eye of a mammalian subject (e.g. human, rodent, etc.) to reduce an elevated intraocular pressure (IOP) involving the use of a multi-coil wireless power transfer assembly. The multi-coil wireless power transfer assembly may be used alone or in combination with a stimulation coil that can be implanted in the eye of a mammalian subject or within a contact lens worn by a mammalian subject.Type: ApplicationFiled: August 6, 2018Publication date: November 26, 2020Inventors: Pedro P. Irazoqui, Gabriel Simon, Gabriel Omar Albors, Jack Williams, Quan Yuan, Zhi Wang, Curtis Slaubaugh
