Patents by Inventor Gabriel Tkacik
Gabriel Tkacik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230123639Abstract: A porous electrospun polymeric nanofiber liquid filtration medium, such as an electrospun mats, used for the removal of viral particles (e.g., parvovirus) and other particles in the 18 nm to 30 nm size range from fluid streams, having a mean flow bubble point measured with perfluorohexane above 100 psi. The electrospun medium includes nanofibers having an average fiber diameter of about 6 nm to about 13 nm, and the nanofiber liquid filtration medium has a mean pore size ranging from about 0.01 ?m to about 0.03 ?m, a porosity ranging from about 80% to about 95%, a thickness ranging from about 1 ?m to about 100 ?m, and a liquid permeability greater than about 10 LMH/psi. The high porosity of the electrospun mats enable much higher water fluxes, thus reducing the time required to complete virus filtration steps on a fluid stream.Type: ApplicationFiled: December 15, 2022Publication date: April 20, 2023Inventors: Mikhail Kozlov, Gabriel Tkacik, Onur Y. Kas, Ajish Potty, Jigneshkumar Patel
-
Publication number: 20230017950Abstract: The present application relates to an unsupported, permanently hydrophilic filtration membrane, and its method of formation. The membrane comprises a polymeric matrix material and a cross-linked polyoxazoline hydrophilic additive blended throughout said matrix material.Type: ApplicationFiled: November 18, 2020Publication date: January 19, 2023Inventors: Jijun GE, Xiaozhu ZHOU, Gabriel TKACIK
-
Patent number: 11261542Abstract: The present invention relates to stable catalyst ink formulations comprising am electrospinning polymer selected from halogen-comprising polymers. The present invention further relates to electrospinning of such ink formulation, to the so-obtained electrospun fibrous mat as well as to articles comprising such electrospun fibrous mat.Type: GrantFiled: January 19, 2015Date of Patent: March 1, 2022Assignee: Merck Patent GmbHInventors: Onur Kas, Ashley Moore, Ryan Sylvia, Gabriel Tkacik
-
Patent number: 11154821Abstract: A composite liquid filtration platform including a composite filtration medium featuring an electrospun polymeric nanofiber layer collected on a porous membrane. When in use, the porous membrane acts as a prefilter used upstream from the polymeric nanofiber layer to remove particles from a liquid stream flowing through the composite filtration structure. The nanofiber layer, positioned downstream from the porous membrane, is used as the retentive layer for critical filtration to provide biosafety assurance, and is responsible for capturing microorganisms like bacteria, mycoplasma or viruses. The composite liquid filtration platform provided herein exhibits permeability advantages over conventional porous membranes or nanofiber mats spun on coarse non-wovens.Type: GrantFiled: March 30, 2012Date of Patent: October 26, 2021Assignee: EMD Millipore CorporationInventors: Onur Y. Kas, Mikhail Kozlov, Gabriel Tkacik, David Nhiem, Philip Goddard, Sherry A. Leon
-
Patent number: 10751669Abstract: The present invention is an integral multilayered composite membrane having at least one ultrafiltration layer made by cocasting or sequentially casting a plurality of polymer solutions onto a support to form a multilayered liquid sheet and immersing the sheet into a liquid coagulation bath to effect phase separation and form a multilayered composite membrane having at least one ultrafiltration layer.Type: GrantFiled: March 12, 2015Date of Patent: August 25, 2020Assignee: EMD MILLIPORE CORPORATIONInventors: Gabriel Tkacik, Philip Goddard, Willem Kools, Nitin Satav
-
Patent number: 10722602Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.Type: GrantFiled: August 2, 2018Date of Patent: July 28, 2020Assignee: EMD MILLIPORE CORPORATIONInventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik
-
Publication number: 20200181804Abstract: The present invention relates to stable catalyst ink formulations comprising am electrospinning polymer selected from halogen-comprising polymers. The present invention further relates to electrospinning of such ink formulation, to the so-obtained electrospun fibrous mat as well as to articles comprising such electrospun fibrous mat.Type: ApplicationFiled: February 12, 2020Publication date: June 11, 2020Applicant: Merck Patent GmbHInventors: Onur KAS, Ashley MOORE, Ryan SYLVIA, Gabriel TKACIK
-
Publication number: 20200173076Abstract: Provided herein are electrospun or electroblown non-woven fiber membranes, methods of making such membranes and lateral flow diagnostic devices comprising such membranes.Type: ApplicationFiled: July 20, 2018Publication date: June 4, 2020Inventors: William Cataldo, Inga Elkina, Kamran Beyzavi, Thomas Fitzgerald, Dennis Aquino, Daniel Callahan, Michael Mansfield, Mikhail Kozlov, Gabriel Tkacik, Murugan Rajendiran, Ramesh Babu Padamati
-
Patent number: 10252199Abstract: A method for removing retroviruses from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention is disclosed. Retroviruses are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a retrovirus LRV greater than about 6, and the nanofiber(s) has a diameter from about 10 nm to about 100 nm. The filtration medium can be in the form of a fibrous electrospun polymeric nanofiber liquid filtration medium mat.Type: GrantFiled: March 2, 2017Date of Patent: April 9, 2019Assignee: EMD Millipore CorporationInventors: Onur Y. Kas, Mikhail Kozlov, Wilson Moya, Sherry A. Leon, Philip Goddard, Jibin Hao, Gabriel Tkacik
-
Publication number: 20190015533Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.Type: ApplicationFiled: August 2, 2018Publication date: January 17, 2019Inventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik
-
Patent number: 10151679Abstract: A method of aerosol integrity testing of filters, capable of detecting single defects that are less than 20 ?m in diameter, and even as small as 2 ?m in diameter, in liquid sterilizing grade filters such as filter cartridges. The method challenges the filter in a dry state with a particle stream of aerosol particles of the appropriate size and in the appropriate concentration, such that at least one or more of the particles in the stream will penetrate a defective region or regions within the membrane but will not penetrate in the integral region of the membrane. Wetting of the filter is not required.Type: GrantFiled: March 1, 2016Date of Patent: December 11, 2018Assignee: EMD Millipore CorporationInventors: Salvatore Giglia, David Nhiem, Gabriel Tkacik
-
Patent number: 10118133Abstract: The present invention is an integral multilayered composite membrane having at least one ultrafiltration layer made by cocasting or sequentially casting a plurality of polymer solutions onto a support to form a multilayered liquid sheet and immersing the sheet into a liquid coagulation bath to effect phase separation and form a multilayered composite membrane having at least one ultrafiltration layer.Type: GrantFiled: January 31, 2017Date of Patent: November 6, 2018Assignee: EMD Millipore CorporationInventors: Gabriel Tkacik, Willem Kools, Nitin Satav, Philip Goddard
-
Patent number: 10119897Abstract: A method of aerosol integrity testing of filters, capable of detecting single defects that are less than 20 ?m in diameter, and even as small as 2 ?m in diameter, in liquid sterilizing grade filters such as filter cartridges. The method challenges the filter in a dry state with a particle stream of aerosol particles of the appropriate size and in the appropriate concentration, such that at least one or more of the particles in the stream will penetrate a defective region or regions within the membrane but will not penetrate in the integral region of the membrane. Wetting of the filter is not required.Type: GrantFiled: March 1, 2016Date of Patent: November 6, 2018Assignee: EMD Millipore CorporationInventors: Salvatore Giglia, David Nhiem, Gabriel Tkacik
-
Patent number: 10064965Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.Type: GrantFiled: August 30, 2017Date of Patent: September 4, 2018Assignee: EMD Millipore CorporationInventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik
-
Patent number: 9994972Abstract: The present invention relates to a method for the preparation of fibers from a catalyst solution by electrospinning and further to articles comprising such fibers.Type: GrantFiled: January 19, 2015Date of Patent: June 12, 2018Assignee: MERCK PATENT GMBHInventors: Onur Kas, Gabriel Tkacik, Ashley Moore, Ryan Sylvia
-
Patent number: 9943616Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.Type: GrantFiled: August 30, 2017Date of Patent: April 17, 2018Assignee: EMD Millipore CorporationInventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik
-
Patent number: 9908086Abstract: The present invention is an integral multilayered composite membrane having at least one ultrafiltration layer made by cocasting or sequentially casting a plurality of polymer solutions onto a support to form a multilayered liquid sheet and immersing the sheet into a liquid coagulation bath to effect phase separation and form a multilayered composite membrane having at least one ultrafiltration layer.Type: GrantFiled: March 23, 2015Date of Patent: March 6, 2018Assignee: EMD Millipore CorporationInventors: Gabriel Tkacik, Philip Goddard, Willem Kools, Nitin Satav
-
Patent number: 9889214Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.Type: GrantFiled: August 30, 2017Date of Patent: February 13, 2018Assignee: EMD Millipore CorporationInventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik
-
Publication number: 20170360971Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.Type: ApplicationFiled: August 30, 2017Publication date: December 21, 2017Inventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik
-
Publication number: 20170360970Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.Type: ApplicationFiled: August 30, 2017Publication date: December 21, 2017Inventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik