Patents by Inventor Gabriel Tkacik

Gabriel Tkacik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230123639
    Abstract: A porous electrospun polymeric nanofiber liquid filtration medium, such as an electrospun mats, used for the removal of viral particles (e.g., parvovirus) and other particles in the 18 nm to 30 nm size range from fluid streams, having a mean flow bubble point measured with perfluorohexane above 100 psi. The electrospun medium includes nanofibers having an average fiber diameter of about 6 nm to about 13 nm, and the nanofiber liquid filtration medium has a mean pore size ranging from about 0.01 ?m to about 0.03 ?m, a porosity ranging from about 80% to about 95%, a thickness ranging from about 1 ?m to about 100 ?m, and a liquid permeability greater than about 10 LMH/psi. The high porosity of the electrospun mats enable much higher water fluxes, thus reducing the time required to complete virus filtration steps on a fluid stream.
    Type: Application
    Filed: December 15, 2022
    Publication date: April 20, 2023
    Inventors: Mikhail Kozlov, Gabriel Tkacik, Onur Y. Kas, Ajish Potty, Jigneshkumar Patel
  • Publication number: 20230017950
    Abstract: The present application relates to an unsupported, permanently hydrophilic filtration membrane, and its method of formation. The membrane comprises a polymeric matrix material and a cross-linked polyoxazoline hydrophilic additive blended throughout said matrix material.
    Type: Application
    Filed: November 18, 2020
    Publication date: January 19, 2023
    Inventors: Jijun GE, Xiaozhu ZHOU, Gabriel TKACIK
  • Patent number: 11261542
    Abstract: The present invention relates to stable catalyst ink formulations comprising am electrospinning polymer selected from halogen-comprising polymers. The present invention further relates to electrospinning of such ink formulation, to the so-obtained electrospun fibrous mat as well as to articles comprising such electrospun fibrous mat.
    Type: Grant
    Filed: January 19, 2015
    Date of Patent: March 1, 2022
    Assignee: Merck Patent GmbH
    Inventors: Onur Kas, Ashley Moore, Ryan Sylvia, Gabriel Tkacik
  • Patent number: 11154821
    Abstract: A composite liquid filtration platform including a composite filtration medium featuring an electrospun polymeric nanofiber layer collected on a porous membrane. When in use, the porous membrane acts as a prefilter used upstream from the polymeric nanofiber layer to remove particles from a liquid stream flowing through the composite filtration structure. The nanofiber layer, positioned downstream from the porous membrane, is used as the retentive layer for critical filtration to provide biosafety assurance, and is responsible for capturing microorganisms like bacteria, mycoplasma or viruses. The composite liquid filtration platform provided herein exhibits permeability advantages over conventional porous membranes or nanofiber mats spun on coarse non-wovens.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: October 26, 2021
    Assignee: EMD Millipore Corporation
    Inventors: Onur Y. Kas, Mikhail Kozlov, Gabriel Tkacik, David Nhiem, Philip Goddard, Sherry A. Leon
  • Patent number: 10751669
    Abstract: The present invention is an integral multilayered composite membrane having at least one ultrafiltration layer made by cocasting or sequentially casting a plurality of polymer solutions onto a support to form a multilayered liquid sheet and immersing the sheet into a liquid coagulation bath to effect phase separation and form a multilayered composite membrane having at least one ultrafiltration layer.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: August 25, 2020
    Assignee: EMD MILLIPORE CORPORATION
    Inventors: Gabriel Tkacik, Philip Goddard, Willem Kools, Nitin Satav
  • Patent number: 10722602
    Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: July 28, 2020
    Assignee: EMD MILLIPORE CORPORATION
    Inventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik
  • Publication number: 20200181804
    Abstract: The present invention relates to stable catalyst ink formulations comprising am electrospinning polymer selected from halogen-comprising polymers. The present invention further relates to electrospinning of such ink formulation, to the so-obtained electrospun fibrous mat as well as to articles comprising such electrospun fibrous mat.
    Type: Application
    Filed: February 12, 2020
    Publication date: June 11, 2020
    Applicant: Merck Patent GmbH
    Inventors: Onur KAS, Ashley MOORE, Ryan SYLVIA, Gabriel TKACIK
  • Publication number: 20200173076
    Abstract: Provided herein are electrospun or electroblown non-woven fiber membranes, methods of making such membranes and lateral flow diagnostic devices comprising such membranes.
    Type: Application
    Filed: July 20, 2018
    Publication date: June 4, 2020
    Inventors: William Cataldo, Inga Elkina, Kamran Beyzavi, Thomas Fitzgerald, Dennis Aquino, Daniel Callahan, Michael Mansfield, Mikhail Kozlov, Gabriel Tkacik, Murugan Rajendiran, Ramesh Babu Padamati
  • Patent number: 10252199
    Abstract: A method for removing retroviruses from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention is disclosed. Retroviruses are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a retrovirus LRV greater than about 6, and the nanofiber(s) has a diameter from about 10 nm to about 100 nm. The filtration medium can be in the form of a fibrous electrospun polymeric nanofiber liquid filtration medium mat.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: April 9, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Onur Y. Kas, Mikhail Kozlov, Wilson Moya, Sherry A. Leon, Philip Goddard, Jibin Hao, Gabriel Tkacik
  • Publication number: 20190015533
    Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
    Type: Application
    Filed: August 2, 2018
    Publication date: January 17, 2019
    Inventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik
  • Patent number: 10151679
    Abstract: A method of aerosol integrity testing of filters, capable of detecting single defects that are less than 20 ?m in diameter, and even as small as 2 ?m in diameter, in liquid sterilizing grade filters such as filter cartridges. The method challenges the filter in a dry state with a particle stream of aerosol particles of the appropriate size and in the appropriate concentration, such that at least one or more of the particles in the stream will penetrate a defective region or regions within the membrane but will not penetrate in the integral region of the membrane. Wetting of the filter is not required.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: December 11, 2018
    Assignee: EMD Millipore Corporation
    Inventors: Salvatore Giglia, David Nhiem, Gabriel Tkacik
  • Patent number: 10118133
    Abstract: The present invention is an integral multilayered composite membrane having at least one ultrafiltration layer made by cocasting or sequentially casting a plurality of polymer solutions onto a support to form a multilayered liquid sheet and immersing the sheet into a liquid coagulation bath to effect phase separation and form a multilayered composite membrane having at least one ultrafiltration layer.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: November 6, 2018
    Assignee: EMD Millipore Corporation
    Inventors: Gabriel Tkacik, Willem Kools, Nitin Satav, Philip Goddard
  • Patent number: 10119897
    Abstract: A method of aerosol integrity testing of filters, capable of detecting single defects that are less than 20 ?m in diameter, and even as small as 2 ?m in diameter, in liquid sterilizing grade filters such as filter cartridges. The method challenges the filter in a dry state with a particle stream of aerosol particles of the appropriate size and in the appropriate concentration, such that at least one or more of the particles in the stream will penetrate a defective region or regions within the membrane but will not penetrate in the integral region of the membrane. Wetting of the filter is not required.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: November 6, 2018
    Assignee: EMD Millipore Corporation
    Inventors: Salvatore Giglia, David Nhiem, Gabriel Tkacik
  • Patent number: 10064965
    Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: September 4, 2018
    Assignee: EMD Millipore Corporation
    Inventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik
  • Patent number: 9994972
    Abstract: The present invention relates to a method for the preparation of fibers from a catalyst solution by electrospinning and further to articles comprising such fibers.
    Type: Grant
    Filed: January 19, 2015
    Date of Patent: June 12, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Onur Kas, Gabriel Tkacik, Ashley Moore, Ryan Sylvia
  • Patent number: 9943616
    Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: April 17, 2018
    Assignee: EMD Millipore Corporation
    Inventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik
  • Patent number: 9908086
    Abstract: The present invention is an integral multilayered composite membrane having at least one ultrafiltration layer made by cocasting or sequentially casting a plurality of polymer solutions onto a support to form a multilayered liquid sheet and immersing the sheet into a liquid coagulation bath to effect phase separation and form a multilayered composite membrane having at least one ultrafiltration layer.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: March 6, 2018
    Assignee: EMD Millipore Corporation
    Inventors: Gabriel Tkacik, Philip Goddard, Willem Kools, Nitin Satav
  • Patent number: 9889214
    Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: February 13, 2018
    Assignee: EMD Millipore Corporation
    Inventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik
  • Publication number: 20170360971
    Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
    Type: Application
    Filed: August 30, 2017
    Publication date: December 21, 2017
    Inventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik
  • Publication number: 20170360970
    Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
    Type: Application
    Filed: August 30, 2017
    Publication date: December 21, 2017
    Inventors: Mikhail Kozlov, Wilson Moya, Gabriel Tkacik