Patents by Inventor Gabriela G. Cezar

Gabriela G. Cezar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomics
    Patent number: 10473641
    Abstract: The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: November 12, 2019
    Assignee: Stemina Biomarker Discovery, Inc.
    Inventors: Paul R. West, April M. Weir-Hauptman, Alan M. Smith, Elizabeth L. R. Donley, Gabriela G. Cezar
  • PREDICTING HUMAN DEVELOPMENTAL TOXICITY OF PHARMACEUTICALS USING HUMAN STEM-LIKE CELLS AND METABOLOMICS
    Publication number: 20140273069
    Abstract: The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.
    Type: Application
    Filed: April 21, 2014
    Publication date: September 18, 2014
    Applicant: STEMINA BIOMARKER DISCOVERY, INC.
    Inventors: Paul R. West, April M. Weir-Hauptman, Alan M. Smith, Elizabeth L.R. Donley, Gabriela G. Cezar
  • REAGENTS AND METHODS FOR USING HUMAN EMBRYONIC STEM CELLS TO EVALUATE TOXICITY OF PHARMACEUTICAL COMPOUNDS AND OTHER CHEMICALS
    Publication number: 20140255969
    Abstract: The invention provides biomarker profiles of cellular metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human embryonic stem cells (hESC) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds.
    Type: Application
    Filed: February 28, 2014
    Publication date: September 11, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventor: Gabriela G. Cezar
  • Reagents and methods for using human embryonic stem cells to evaluate toxicity of pharmaceutical compounds and other chemicals
    Patent number: 8703483
    Abstract: The invention provides biomarker profiles of cellular metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human embryonic stem cells (hESC) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: April 22, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Gabriela G. Cezar
  • Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomics
    Patent number: 8703424
    Abstract: The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: April 22, 2014
    Assignee: Stemina Biomarker Discovery, Inc.
    Inventors: Paul R. West, April M. Weir-Hauptman, Alan M. Smith, Elizabeth L. R. Donley, Gabriela G. Cezar
  • Predicting Human Developmental Toxicity of Pharmaceuticals Using Human Stem-Like Cells and Metabolomics
    Publication number: 20110312019
    Abstract: The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.
    Type: Application
    Filed: March 22, 2011
    Publication date: December 22, 2011
    Applicant: Stemina Biomarker Discovery, Inc.
    Inventors: Paul R. WEST, April M. WEIR-HAUPTMAN, Alan M. SMITH, Elizabeth L.R. DONLEY, Gabriela G. CEZAR
  • Biomarkers of Ionizing Radiation Response
    Publication number: 20080187952
    Abstract: The invention provides methods for measuring cellular response to ionization radiation (IR). The invention also provides a plurality of diagnostic and prognostic cancer biomarkers for assessing cellular response to IR.
    Type: Application
    Filed: January 31, 2008
    Publication date: August 7, 2008
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Gabriela G. Cezar, Alan M. Smith