Patents by Inventor Gabriela Grasa

Gabriela Grasa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enantioselective process for preparing a substituted alkanoic acid
    Patent number: 8680278
    Abstract: The present invention is directed to a process for enantioselectively preparing substituted piperidine alkanoic acid integrin antagonist compounds.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: March 25, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: William A. Kinney, Christopher A. Teleha, Shyamali Ghosh, Bruce E. Maryanoff, Gabriela Grasa, Antonio Zanotti-Gerosa, Jonathan Alan Medlock
  • Sulphonylated Diphenylethylenediamines, Method For Their Preparation And Use In Transfer Hydrogenation Catalysis
    Publication number: 20080081930
    Abstract: A diamine of formula (I) is described, in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
    Type: Application
    Filed: November 1, 2005
    Publication date: April 3, 2008
    Inventors: Beatriz Dominguez, Antonio Zanotti-Gerosa, Gabriela Grasa, Jonathan Medlock
  • Catalysts
    Publication number: 20070066850
    Abstract: Catalysts suitable for asymmetric hydrogenation reactions is described comprising the reaction product of a group (8) transition metal compound a chiral phosphine and a chiral diamine of formula (1) in which R1, R2 R3 or R4 are independently hydrogen, a saturated or unsaturated alkyl, or cycloalkyl group, an aryl group, a urethane or sulphonyl group and R5, R6, R7 or R8 are independently hydrogen, a saturated or unsaturated alkyl or cycloalkyl group, or an aryl group, at least one of R1, R2, R3 or R4 is hydrogen and A is a linking group comprising one or two substituted or unsubstituted carbon atoms.
    Type: Application
    Filed: July 7, 2004
    Publication date: March 22, 2007
    Inventors: William Hems, Gabriela Grasa
  • Convenient and efficient Suzuki-Miyaura cross-coupling catalyzed by a palladium/diazabutadiene system
    Patent number: 6583307
    Abstract: A Pd(OAc)2/diazabutadiene system has been developed for the catalytic cross-coupling of aryl halides with arylboronic acids. A combination of the diazabutadiene DAB-Cy (1, N,N′-Dicyclohexyl-1,4-dizabutadiene) and Pd(OAc)2 was found to form an excellent catalyst for the Suzuki-Miyaura cross-coupling of various aryl bromides and activated aryl chlorides with arylboronic acids.
    Type: Grant
    Filed: March 7, 2002
    Date of Patent: June 24, 2003
    Assignee: University of New Orleans Research and Technology Foundation, Inc.
    Inventors: Steven P. Nolan, Gabriela Grasa
  • Convenient and efficient suzuki-miyaura cross-coupling catalyzed by a palladium/diazabutadiene system
    Publication number: 20020198423
    Abstract: A Pd(OAc)2/diazabutadiene system has been developed for the catalytic cross-coupling of aryl halides with arylboronic acids. A combination of the diazabutadiene DAB-Cy (1, N, N′-Dicyclohexyl-1,4-dizabutadiene) and Pd(OAc)2 was found to form an excellent catalyst for the Suzuki-Miyaura cross-coupling of various aryl bromides and activated aryl chlorides with arylboronic acids.
    Type: Application
    Filed: March 7, 2002
    Publication date: December 26, 2002
    Inventors: Steven P. Nolan, Gabriela Grasa