Patents by Inventor Gabriela Mustata

Gabriela Mustata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule analogs of the nemo binding peptide
    Patent number: 10758522
    Abstract: The invention is directed to a method of inhibiting, within a living cell, the interaction between NF-?B essential modulator (“NEMO”) with I?B kinase-? (IKK-?) at the NEMO binding domain (NBD), comprising exposing the cell to an effective amount or concentration of a compound of the invention, a NEMO-binding domain analog (NBDA). The invention is further directed to a method of treating a condition in a patient, wherein inhibiting the interaction between NF-?B essential modulator (“NEMO”) with I?B kinase-? (IKK-?) at the NEMO binding domain (NBD) is medically indicated, comprising administering to the patient an effective dose of a compound of the invention. Conditions that can be treated by a method of the invention includes muscular dystrophy, asthma, inflammatory bowel disease, multiple sclerosis, Parkinson's Disease, arthritis, diabetes, graft versus host disease, accelerated aging, heart ischemia, cancer, UV-induced skin damage, or an age-related pathology.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: September 1, 2020
    Assignee: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Paul Robbins, Laura Niedernhofer, Theodore Kamenecka, Gabriela Mustata Wilson
  • Small Molecule Analogs of the Nemo Binding Peptide
    Publication number: 20180169078
    Abstract: The invention is directed to a method of inhibiting, within a living cell, the interaction between NF-?B essential modulator (“NEMO”) with I?B kinase-? (IKK-?) at the NEMO binding domain (NBD), comprising exposing the cell to an effective amount or concentration of a compound of the invention, a NEMO-binding domain analog (NBDA). The invention is further directed to a method of treating a condition in a patient, wherein inhibiting the interaction between NF-?B essential modulator (“NEMO”) with I?B kinase-? (IKK-?) at the NEMO binding domain (NBD) is medically indicated, comprising administering to the patient an effective dose of a compound of the invention. Conditions that can be treated by a method of the invention includes muscular dystrophy, asthma, inflammatory bowel disease, multiple sclerosis, Parkinson's Disease, arthritis, diabetes, graft versus host disease, accelerated aging, heart ischemia, cancer, UV-induced skin damage, or an age-related pathology.
    Type: Application
    Filed: May 25, 2016
    Publication date: June 21, 2018
    Inventors: Paul Robbins, Laura Niedernhofer, Theodore Kamenecka, Gabriela Mustata Wilson
  • Phenoxy alkyl diethanolamine and diisopropanolamine compounds for delivering active agents
    Patent number: 9458089
    Abstract: The present invention relates to particular phenoxy alkyl diethanolamine and diisopropanolamine compounds for delivering biologically active agents to a target. These compounds are well suited for forming non-covalent mixtures with active agents for oral, intracolonic, pulmonary, and other routes of administration to animals.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: October 4, 2016
    Assignee: Emisphere Technologies, Inc.
    Inventors: Gabriela Mustata, Dahua Pan, David Gschneidner
  • PHENOXY ALKYL DIETHANOLAMINE AND DIISOPROPANOLAMINE COMPOUNDS FOR DELIVERING ACTIVE AGENTS
    Publication number: 20150321993
    Abstract: The present invention relates to particular phenoxy alkyl diethanolamine and diisopropanolamine compounds for delivering biologically active agents to a target. These compounds are well suited for forming non-covalent mixtures with active agents for oral, intracolonic, pulmonary, and other routes of administration to animals.
    Type: Application
    Filed: August 22, 2013
    Publication date: November 12, 2015
    Applicant: Emisphere Technologies, Inc.
    Inventors: Gabriela Mustata, Dahua Pan, David Gschneidner
  • Cyclopropyl compounds and compositions for delivering active agents
    Patent number: 8541362
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: August 21, 2006
    Date of Patent: September 24, 2013
    Assignee: Emisphere Technologies, Inc.
    Inventors: Pingwah Tang, Steven Dinh, Jongbin Lee, Puchun Liu, Gabriela Mustata
  • CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS
    Publication number: 20090220451
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: August 21, 2006
    Publication date: September 3, 2009
    Applicant: EMISPHERE TECHNOLOGIES, INC.
    Inventors: Pingwah Tang, Steven Dinh, Jongbin Lee, Puchun Liu, Gabriela Mustata