Patents by Inventor Gabriele Fachin

Gabriele Fachin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors
    Patent number: 8598172
    Abstract: Dihydropteridin-6-one derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: December 3, 2013
    Assignee: Nerviano Medical Sciences S.r.l.
    Inventors: Michele Caruso, Italo Beria, Maria Gabriella Brasca, Helena Posteri, Gabriele Fachin
  • SUBSTITUTED DIHYDROPTERIDIN-6-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20110053944
    Abstract: Dihydropteridin-6-one derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: November 26, 2008
    Publication date: March 3, 2011
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Michele Caruso, Italo Beria, Maria Gabriella Brasca, Helena Posteri, Gabriele Fachin
  • Bioactive derivatives of camptothecin
    Patent number: 6376617
    Abstract: Water soluble polymeric conjugates of camptothecin consist essentially of N-(2-hydroxypropyl)methacryloylamide units linked via a spacer group to a residue of a camptothecin such as irinotecan or its non-soluble metabolite, 7-ethyl-10-hydroxy-camptothecin. The conjugates possess enhance antitumor activity and decreased toxicity with respect to the free drug. A process for their preparation and the pharmaceutical compositions containing them are also described.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: April 23, 2002
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Francesco Angelucci, Gabriele Fachin, Valeria Caiolfa, Antonino Suarato
  • BIOACTIVE DERIVATIVES OF CAMPTOTHECIN
    Publication number: 20020032331
    Abstract: Water soluble polymeric conjugates of camptothecin consist essentially of N-(2-hydroxypropyl)methacryloylamide units linked via a spacer group to a residue of a camptothecin such as irinotecan or its non-soluble metabolite, 7-ethyl-10-hydroxy amptothecin. The conjugates possess enhance antitumor activity and decreased toxicity with respect to the free drug. A process for their preparation and the pharmaceutical compositions containing them are also described.
    Type: Application
    Filed: June 3, 1999
    Publication date: March 14, 2002
    Inventors: FRANCESCO ANGELUCCI, GABRIELE FACHIN, VALERIA CAIOLFA, ANTONINO SUARATO
  • Polymeric derivatives of camptothecins
    Patent number: 6328953
    Abstract: The invention relates to polymeric conjugates of 20-O-[glycyl-aminoacyl-glycyl]-camptothecins and a process for producing the same.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: December 11, 2001
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Francesco Angelucci, Fabrizio Orzi, Gabriele Fachin, Valeria Caiolfa, Moreno Zamai, Antonino Suarato