Patents by Inventor Gabriele Gradl

Gabriele Gradl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7501233
    Abstract: A method is described for non-destructive measurement of vitality of biological cells, especially for determination of apoptosis, in which the at least one cell is exposed to high-frequency alternating, especially rotating, electric fields and/or impedance test fields, and at least one rotation measurement, one dielectrophoresis measurement and/or one impedance measurement is performed with the cell for at least one frequency range or individual frequencies, from which at least one measurement parameter is determined that is characteristic of the vitality state of the cell.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: March 10, 2009
    Assignee: Perkinelmer Cellular Technologies Germany GmbH
    Inventors: Gabriele Gradl, Thomas Schnelle, Torsten Müller, Christoph Reichle
  • Publication number: 20080113333
    Abstract: A method for the prevention of the adhesion of particles, in particular cells and cellular components in solution to surfaces, characterized in that to the solution is added at least one polyalcohol.
    Type: Application
    Filed: September 13, 2007
    Publication date: May 15, 2008
    Applicant: EVOTEC OAI AG
    Inventor: Gabriele Gradl
  • Patent number: 7300793
    Abstract: A method for the prevention of the adhesion of particles, in particular cells and cellular components in solution to surfaces, characterized in that to the solution is added at least one polyalcohol.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: November 27, 2007
    Assignee: Evotec Technologies GmbH
    Inventor: Gabriele Gradl
  • Publication number: 20060152708
    Abstract: Disclosed is a method for measuring properties of particles that move through a fluidic microsystem, the particles being suspended in a liquid. According to the inventive method, a first parameter of a specific particle is first measured at a first test station (11). A second parameter of the particle is then measured at an interval from the first measurement at a second test station (12) which is spatially separated from the first test station (11), and the first and second parameters are jointly evaluated in a correlated manner, the first and second parameters being characteristic of different properties of the tested particle. The evaluation comprises a comparison of the first and second parameters with predetermined expected values. Another measurement is taken or manipulations are performed on the tested particle according to the result of the comparison. Also disclosed is a fluidic microsystem that is designed for implementing the inventive method.
    Type: Application
    Filed: February 4, 2004
    Publication date: July 13, 2006
    Inventors: Torsten Muller, Stefan Hummel, Annette Pfennig, Gabriele Gradl, Axel Bonsen, Thomas Schnelle, Rudiger Meyer
  • Publication number: 20060139638
    Abstract: The invention relates to an method of analysing biological particles, in particular to be conducted in a cell sorter, with following steps: placing the particles to be analysed into a carrier flow, carrying out a first analysis of the particles moving with the carrier flow, selecting at least one particle in dependence on the result of the first analysis, carrying out a second analysis of the selected particle in a decelerated condition. Furthermore, the invention comprises a corresponding analysis device.
    Type: Application
    Filed: February 4, 2004
    Publication date: June 29, 2006
    Inventors: Torsten Muller, Stefan Hummel, Annette Pfennig, Gabriele Gradl, Axel Bonsen, Rudiger Meyer
  • Publication number: 20040175354
    Abstract: A method for the prevention of the adhesion of particles, in particular cells and cellular components in solution to surfaces, characterized in that to the solution is added at least one polyalcohol.
    Type: Application
    Filed: January 8, 2004
    Publication date: September 9, 2004
    Inventor: Gabriele Gradl
  • Patent number: 6727451
    Abstract: To manipulate microparticles in a fluid that intersects a first channel or several first channels as a stream, one or more microparticles (14) are exposed to electrical field barriers that change their direction from the direction of flow toward the edge of the flow to a lateral hole (17) of the respective first channel. As a result, microparticles can be moved back and forth between streaming fluids. Preferred applications include treatment, separating, sorting or confinement procedures.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: April 27, 2004
    Assignee: Evotec Technologies GmbH
    Inventors: Günter Fuhr, Rolf Hagedorn, Torsten Müller, Thomas Schnelle, Gabriele Gradl
  • Publication number: 20040053211
    Abstract: A method is described for non-destructive measurement of vitality of biological cells, especially for determination of apoptosis, in which the at least one cell is exposed to high-frequency alternating, especially rotating, electric fields and/or impedance test fields, and at least one rotation measurement, one dielectrophoresis measurement and/or one impedance measurement is performed with the cell for at least one frequency range or individual frequencies, from which at least one measurement parameter is determined that is characteristic of the vitality state of the cell.
    Type: Application
    Filed: September 3, 2003
    Publication date: March 18, 2004
    Inventors: Gabriele Gradl, Thomas Schnelle
  • Patent number: 6492175
    Abstract: An electroporation and/or fusion treatment of microscopic objects occurs in a medium between at least two electrodes, with the electrodes being miniaturized electrodes in a microsystem with a channel structure which is set up for the flow-through of the medium with the objects.
    Type: Grant
    Filed: August 6, 2001
    Date of Patent: December 10, 2002
    Assignee: Evotec Bio Systems AG
    Inventors: Torsten Müller, Thomas Schnelle, Günter Fuhr, Stephen Graham Shirley, Gabriele Gradl