Patents by Inventor Gabriele M. Cook

Gabriele M. Cook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic luciferase gene and protein
    Publication number: 20140087402
    Abstract: A codon optimized and stabilized luciferase gene and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in mammalian cells, are disclosed. This new luciferase exhibits long-wavelength light emission, as well as improved thermostability and higher expression levels in mammalian cell systems, compared to native luciferase. Assays using this new enzyme for measuring various biological metabolic functions are described.
    Type: Application
    Filed: December 4, 2012
    Publication date: March 27, 2014
    Applicant: Marker Gene Technologies, Inc.
    Inventors: Daniel J. Coleman, John J. Naleway, Gabriele M. Cook, Ying Jiang
  • Modified luciferase gene and protein
    Patent number: 8450054
    Abstract: A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from Luciola cruciata (Japanese firefly) and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in mammalian cells, are disclosed. This new luciferase exhibits long-wavelength light emission, as well as improved thermostability and higher expression levels in mammalian cell systems, compared to native luciferase. Assays using this new enzyme for measuring various biological metabolic functions are described.
    Type: Grant
    Filed: December 9, 2010
    Date of Patent: May 28, 2013
    Assignee: Marker Gene Technologies, Inc.
    Inventors: Ying Jiang, Daniel J. Coleman, John J. Naleway, Gabriele M. Cook
  • Modified luciferase protein
    Patent number: 8206961
    Abstract: A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from Luciola cruciata (Japanese firefly) and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in mammalian cells, are disclosed. This new luciferase exhibits long-wavelength light emission, as well as improved thermostability and higher expression levels in mammalian cell systems, compared to native luciferase.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: June 26, 2012
    Assignee: Marker Gene Technologies, Inc.
    Inventors: Daniel J. Coleman, John J. Naleway, Gabriele M. Cook
  • MODIFIED LUCIOLA CRUCIATA LUCIFERASE PROTEIN
    Publication number: 20120034634
    Abstract: A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from Luciola cruciata (Japanese firefly) and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in mammalian cells, are disclosed. This new luciferase exhibits long-wavelength light emission, as well as improved thermostability and higher expression levels in mammalian cell systems, compared to native luciferase.
    Type: Application
    Filed: May 24, 2010
    Publication date: February 9, 2012
    Inventors: Daniel J. Coleman, John J. Naleway, Gabriele M. Cook
  • Modified luciola cruciata luciferase gene and protein
    Publication number: 20120028257
    Abstract: A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from Luciola cruciata (Japanese firefly) and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in mammalian cells, are disclosed. This new luciferase exhibits long-wavelength light emission, as well as improved thermostability and higher expression levels in mammalian cell systems, compared to native luciferase. Assays using this new enzyme for measuring various biological metabolic functions are described.
    Type: Application
    Filed: December 9, 2010
    Publication date: February 2, 2012
    Inventors: Ying Jiang, Daniel J. Coleman, John J. Naleway, Gabriele M. Cook
  • Modified luciferase gene and protein
    Patent number: 7723502
    Abstract: A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from Luciola cruciata (Japanese firefly) and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in mammalian cells, are disclosed. This new luciferase exhibits long-wavelength light emission, as well as improved thermostability and higher expression levels in mammalian cell systems, compared to native luciferase.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: May 25, 2010
    Assignee: Marker Gene Technologies, Inc
    Inventors: Daniel J. Coleman, John J. Naleway, Gabriele M. Cook
  • MODIFIED LUCIOLA CRUCIATA LUCIFERASE GENE AND PROTEIN
    Publication number: 20100093029
    Abstract: A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from Luciola cruciata (Japanese firefly) and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in mammalian cells, are disclosed. This new luciferase exhibits long-wavelength light emission, as well as improved thermostability and higher expression levels in mammalian cell systems, compared to native luciferase.
    Type: Application
    Filed: October 10, 2008
    Publication date: April 15, 2010
    Inventors: Daniel J. Coleman, John J. Naleway, Gabriele M. Cook