Patents by Inventor Gabriele Maria Schaefer

Gabriele Maria Schaefer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ASSAYS FOR FIXED DOSE COMBINATIONS
    Publication number: 20230314420
    Abstract: Assays to analyze quality and quantity attributes of fixed dose combinations are provided. In particular, assays for fixed dose combinations of two anti-HER2 antibodies, and for subcutaneous formulations comprising pertuzumab and trastuzumab are described herein.
    Type: Application
    Filed: January 11, 2023
    Publication date: October 5, 2023
    Applicants: Genentech, Inc., Hoffmann-La Roche Inc.
    Inventors: Cécile AVENAL, Nadine HOLZMANN, Michael NOAK, Tania RUCHTY, Gabriele Maria SCHAEFER, Franziska ZAEHRINGER
  • ?-heregulin
    Patent number: 7585673
    Abstract: A novel member of the heregulin superfamily has been identified which is designated “?-HRG”. This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. ?-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of ?-HRG nucleic acid for the recombinant production of ?-HRG). ?-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.
    Type: Grant
    Filed: July 1, 2005
    Date of Patent: September 8, 2009
    Assignee: Genentech, Inc.
    Inventors: Gabriele Maria Schaefer, Mark Sliwkowski
  • GAMMA-HEREGULIN
    Publication number: 20090042797
    Abstract: A novel member of the heregulin superfamily has been identified which is designated “?-HRG”. This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. ?-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of ?-HRG nucleic acid for the recombinant production of ?-HRG). ?-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.
    Type: Application
    Filed: July 3, 2008
    Publication date: February 12, 2009
    Inventors: Gabriele Maria SCHAEFER, Mark Sliwkowski
  • Antibodies that bind gamma-heregulin
    Patent number: 6916624
    Abstract: A novel member of the heregulin superfamily has been identified which is designated “?-HRG”. This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. ?-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of ?-HRG nucleic acid for the recombinant production of ?-HRG). ?-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: July 12, 2005
    Assignee: Genentech, Inc.
    Inventors: Gabriele Maria Schaefer, Mark Sliwkowski
  • Gamma-heregulin
    Publication number: 20030078389
    Abstract: A novel member of the heregulin superfamily has been identified which is designated “&ggr;-HRG”. This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. &ggr;-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of &ggr;-HRG nucleic acid for the recombinant production of &ggr;-HRG). &ggr;-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.
    Type: Application
    Filed: November 8, 2002
    Publication date: April 24, 2003
    Applicant: Genentech, Inc.
    Inventors: Gabriele Maria Schaefer, Mark Sliwkowski
  • Gamma-heregulin
    Patent number: 6500941
    Abstract: A novel member of the heregulin superfamily has been identified which is designated “&ggr;-HRG”. This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. &ggr;-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of &ggr;-HRG nucleic acid for the recombinant production of &ggr;-HRG). &ggr;-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.
    Type: Grant
    Filed: February 28, 2000
    Date of Patent: December 31, 2002
    Assignee: Genentech, Inc.
    Inventors: Gabriele Maria Schaefer, Mark Sliwkowski
  • Gamma-heregulin
    Patent number: 6096873
    Abstract: A novel member of the heregulin superfamily has been identified which is designated ".gamma.-HRG". This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. .gamma.-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of .gamma.-HRG nucleic acid for the recombinant production of .gamma.-HRG). .gamma.-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: August 1, 2000
    Assignee: Genentech, Inc.
    Inventors: Gabriele Maria Schaefer, Mark Sliwkowski