Patents by Inventor Gabriele Meli

Gabriele Meli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Manufacturing process for preparing gadoteridol
    Patent number: 11905257
    Abstract: The invention relates to a process for preparing Gadoteridol of formula (I). In particular, the process comprises the use of propylene oxide in the alkylation step of the compound of formula (II), wherein propylene oxide is directly reacted with the compound of formula (II) without being isolated, and wherein propylene oxide is obtained on demand by decomposition of propylene carbonate in the presence of an alkaline or alkaline earth metal halide as catalyst.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: February 20, 2024
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Roberta Fretta, Luciano Lattuada, Gabriele Meli
  • MANUFACTURING PROCESS FOR PREPARING GADOTERIDOL
    Publication number: 20230391735
    Abstract: The invention relates to a process for preparing Gadoteridol of formula (I). In particular, the process comprises the use of propylene oxide in the alkylation step of the compound of formula (II), wherein propylene oxide is directly reacted with the compound of formula (II) without being isolated, and wherein propylene oxide is obtained on demand by decomposition of propylene carbonate in the presence of an alkaline or alkaline earth metal halide as catalyst.
    Type: Application
    Filed: December 1, 2021
    Publication date: December 7, 2023
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta FRETTA, Luciano LATTUADA, Gabriele MELI
  • Process for the iodination of aromatic compounds
    Patent number: 9238615
    Abstract: The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5-disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: January 19, 2016
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Attilio Citterio, Luciano Lattuada, Gabriella Leonardi, Fulvio Uggeri, Evelin Vignale, Massimo Visigalli, Aurelia Ferrigato, Gabriele Meli, Roberta Fretta, Roberta Mazzon
  • Process For The Iodination Of Aromatic Compounds
    Publication number: 20120041224
    Abstract: The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5-disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.
    Type: Application
    Filed: April 8, 2010
    Publication date: February 16, 2012
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Attilio Citterio, Luciano Lattuada, Gabriella Leonardi, Fulvio Uggeri, Evelin Vignale, Massimo Visigalli, Aurelia Ferrigato, Gabriele Meli, Roberta Fretta, Roberta Mazzon