Patents by Inventor Gabriele Norcini

Gabriele Norcini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphonyldipeptides useful in the treatment of cardiovascular diseases
    Patent number: 5760285
    Abstract: Compounds of formula (II) ##STR1## wherein R is a biphenyl group optionally substituted by one or more substituents, the same or different, selected among halogen atoms, hydroxy groups, alkoxy, alkyl or thioalkyl groups having from 1 to 6 carbon atoms in the alkyl moiety, carboxylic groups, nitro groups, amino, mono- or di-alkylamino groups having from 1 to 6 carbon atoms in the alkyl moiety; R.sub.1 is a hydrogen atom or a straight or branched C.sub.1 -C.sub.4 allyl; R.sub.2 is a straight or branched C.sub.1 -C.sub.6 alkyl or an arylalkyl having from 1 to 6 carbon atoms in the alkyl moiety wherein the aryl is a phenyl, a naphthyl or a 5 or 6 membered aromatic heterocycle with one or two heteroatoms selected among nitrogen, oxygen and sulphur, optionally substituted as above indicated for the R substituent; R.sub.3 is a straight or branched C.sub.1 -C.sub.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: June 2, 1998
    Assignee: Zambon Group S.p.A.
    Inventors: Gabriele Norcini, Gabriele Morazzoni, Francesco Santangelo
  • Phosphinic acid derivatives with metallopeptidase inhibitory activity
    Patent number: 5739123
    Abstract: Compounds of formula (I), ##STR1## wherein R is a biphenyl group optionally substituted, by one or more substituents, the same or different selected among halogen atoms, hydroxy groups, alkoxy, alkyl thioalkyl or alkoxycarbonyl groups having from 1 to 6 carbon atoms in the alkyl moiety, C.sub.1 -C.sub.3 alkyl groups containing one or more fluorine atoms, carboxy groups, nitro groups, amino or aminocarbonyl groups, acylamino groups, aminosulphonyl groups, momo- or di-alkylamino groups having from 1 to 6 carbon atoms in the alkyl moiety, mono- or di-alkylamino-carbonyl groups having from 1 to 6 carbon atoms in the alkyl moiety; R.sub.1 is a hydrogen atom, a straight or branched C.sub.1 -C.sub.
    Type: Grant
    Filed: November 27, 1996
    Date of Patent: April 14, 1998
    Assignee: Zambon Group S.p.A.
    Inventors: Gabriele Norcini, Daniela Botta, Francesco Santangelo, Gabriele Morazzoni
  • Phosphinic acid derivatives with metallopeptidase inhibitory activity
    Patent number: 5716943
    Abstract: Compounds of formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and n have the meanings reported in the description are described.The compounds of formula I are endowed with a dual ACE-inhibitory and NEP-inhibitory activity and are useful in the treatment of cardiovascular diseases.
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: February 10, 1998
    Assignee: Zambon Group. S.p.A.
    Inventors: Gabriele Norcini, Daniela Botta, Francesco Santangelo, Claudio Semeraro
  • .beta.-mercapto-propanamide derivatives useful in the treatment of cardiovascular diseases
    Patent number: 5506259
    Abstract: Compounds of formula ##STR1## wherein R, R.sub.1, R.sub.2, Het and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active ingredients are described. The compounds of formula I are useful in the treatment of cardiovascular diseases.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: April 9, 1996
    Assignee: Zambon Group S.p.A.
    Inventors: Gabriele Norcini, Francesco Santangelo
  • Diphosphates of catecholamines and pharmaceutical compositions containing them
    Patent number: 5438047
    Abstract: Diphosphates of catecholamines having formula (I) wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X have the meanings reported in the description, are useful in the therapy of cardiovascular and renal diseases.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: August 1, 1995
    Assignee: Zambon Group S.p.A.
    Inventors: Francesco Santangelo, Cesare Casagrande, Gabriele Norcini
  • N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases
    Patent number: 5438046
    Abstract: Compounds of formula ##STR1## wherein Y, R.sub.1, R.sub.2, Het, X and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active ingredients are described. The compounds of formula I are useful in the treatment of cardiovascular diseases.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: August 1, 1995
    Assignee: Zambon Group S.p.A.
    Inventors: Gabriele Norcini, Francesco Santangelo
  • Steroid compounds active on the cardiovascular system
    Patent number: 5426179
    Abstract: Steroid compounds active on the cardiovascular system of formula ##STR1## wherein X, n, R, R.sub.1 and R.sub.2 have the meanings mentioned in the description are described.
    Type: Grant
    Filed: February 12, 1992
    Date of Patent: June 20, 1995
    Assignee: Zambon Group S.p.A.
    Inventors: Giorgio Bertolini, Cesare Casagrande, Stefania Montanari, Gabriele Norcini, Francesco Santangelo
  • 17-aryl-substituted steroidal compounds active on the cardiovascular system
    Patent number: 5424304
    Abstract: Cardioactive steroidal compounds of the formula I ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 have the meanings shown in the description, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: June 13, 1995
    Inventors: Giorgio Bertolini, Cesare Casagrande, Gabriele Norcini, Francesco Santangelo
  • Phenoxyethyl amine compounds active on the cardiovascular system
    Patent number: 5151414
    Abstract: Compounds of formula ##STR1## (wherein R, R.sub.1, R.sub.2, R.sub.3, n, m and p have the meanings reported in the specification), their preparation and the compositions for pharmaceutical use containing them as active ingredient are described.The compounds of formula I have dopaminergic vasodilator activity and they may be used in pharmaceutical field.
    Type: Grant
    Filed: July 31, 1991
    Date of Patent: September 29, 1992
    Assignee: SIMES Societa Italiana Medicinali e Sintetici S.p.A.
    Inventors: Cesare Casagrande, Gabriele Norcini, Francesco Santangelo, Claudio Semeraro
  • Compounds active on the cardiovascular system
    Patent number: 5070106
    Abstract: Compounds of formula ##STR1## (wherein R, R.sub.1, R.sub.2, R.sub.3, n, m, and p have the meanings reported in the specification), their preparation and the compositions for pharmaceutical use containing them as active ingredient are described.The compounds of formula I have dopaminergic vasodilator activity and they may be used in pharmaceutical field.
    Type: Grant
    Filed: February 22, 1991
    Date of Patent: December 3, 1991
    Assignee: Simes Societa Italiana Medicinali e Sintetici S.p.A.
    Inventors: Cesare Casagrande, Gabriele Norcini, Francesco Santangelo, Claudio Semeraro