Patents by Inventor Gabriella Dessole

Gabriella Dessole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridazinone derivatives as PARP inhibitors
    Patent number: 8268827
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
    Type: Grant
    Filed: November 14, 2008
    Date of Patent: September 18, 2012
    Assignee: Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA.
    Inventors: Danila Branca, Gabriella Dessole, Federica Ferrigno, Philip Jones, Olaf Kinzel, Samuele Lillini, Ester Muraglia, Giovanna Pescatore, Carsten Schultz-Fademrecht
  • Nucleoside derivatives as inhibitors of viral polymerases
    Patent number: 8183216
    Abstract: A class of nucleoside derivatives of formula (I), as defined herein, that are useful as inhibitors of RNA-dependent RNA viral replication and in particular HCV replication, are provided. Also provided are processes for the synthesis and use of such compounds for treating or preventing HCV infection. formula (I).
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: May 22, 2012
    Assignee: Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.A.
    Inventors: Maria Emilia Di Francesco, Vincenzo Summa, Gabriella Dessole
  • 1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS
    Publication number: 20110183974
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smo antagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.
    Type: Application
    Filed: July 27, 2009
    Publication date: July 28, 2011
    Inventors: Gabriella Dessole, Philip Jones, Laura Llauger Bufi, Ester Muraglia, Jesus Maria Ontoria Ontoria, Caterina Torrisi
  • PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS
    Publication number: 20100261709
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinaldamage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
    Type: Application
    Filed: November 14, 2008
    Publication date: October 14, 2010
    Inventors: Danila Branca, Gabriella Dessole, Federica Ferrigno, Philip Jones, Olaf Kinzel, Samuele Lillini, Ester Muraglia, Giovanna Pescatore, Carsten Schultz-Fademrecht
  • Nucleoside Derivatives as Inhibitors of Viral Polymerases
    Publication number: 20100210581
    Abstract: A class of nucleoside derivatives of formula (I), as defined herein, that are useful as inhibitors of RNA-dependent RNA viral replication and in particular HCV replication, are provided. Also provided are processes for the synthesis and use of such compounds for treating or preventing HCV infection.
    Type: Application
    Filed: September 16, 2008
    Publication date: August 19, 2010
    Applicant: Istitute de Ricerche di Biologia Molecolare P. Angeletti
    Inventors: Maria Emilia Di Francesco, Vincenzo Summa, Gabriella Dessole