Patents by Inventor Gabriella Romano

Gabriella Romano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7169890
    Abstract: The invention regards a process for the production of ramoplanin-like derivatives of formula (I): RAMO-NC—CO—R (I), wherein the radical R represents a hydrocarbon radical and the portion RAMO-NH— represents deacylated ramoplanin, any of its factors or ramoplanose. The compound of Formula (I) are obtained by reacting a carboxylic acid R—COOH with deacylated ramoplanin, any of its factors or ramoplanose protected on the ornitine amino groups. New compounds wherein the hydrocarbon radical R is different form those characaterizing the ramoplanin and ramoplanose natural products and their tetrahydro-derivatives are calimed. The new compounds have the same or better antinfective activity, lower haemolytic effect and better tolerability profile than ramoplanin.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: January 30, 2007
    Assignee: Vicuron Pharmaceuticals Inc.
    Inventors: Romeo Ciabatti, Sonia Maffioli, Anna Checchia, Gabriella Romano, Gianpaolo Candiani, Gianbattista Panzone
  • Publication number: 20060211603
    Abstract: Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
    Type: Application
    Filed: August 4, 2005
    Publication date: September 21, 2006
    Applicant: VICURON PHARMACEUTICALS INC.
    Inventors: Bore Raju, Romeo Ciabatti, Sonia Maffioli, Upinder Singh, Gabriella Romano, Elena Michelucci, Paolo Tiseni, Gianpaolo Candiani, Bum Kim, Hardwin O'Dowd
  • Publication number: 20050106691
    Abstract: The invention regards a process for the production of ramoplanin-like derivatives of formula (I): RAMO-NC—CO—R (I), wherein the radical R represents a hydrocarbon radical and the portion RAMO-NH— represents deacylated ramoplanin, any of its factors or ramoplanose. The compound of Formula (I) are obtained by reacting a carboxylic acid R—COOH with deacylated ramoplanin, any of its factors or ramoplanose protected on the ornitine amino groups. New compounds wherein the hydrocarbon radical R is different form those characaterizing the ramoplanin and ramoplanose natural products and their tetrahydro-derivatives are calimed. The new compounds have the same or better antinfective activity, lower haemolytic effect and better tolerability profile than ramoplanin.
    Type: Application
    Filed: February 26, 2003
    Publication date: May 19, 2005
    Applicant: VICURON PHARMACEUTICALS INC.
    Inventors: Romeo Ciabatti, Sonia Maffiolt, Anna Checchia, Gabriella Romano, Gianpaolo Candiani, Gianbattista Panzone
  • Patent number: 5752941
    Abstract: The invention relates to central venous polyurethane catheters with a thin hydrophilic coating loaded with an antibiotic of the ramoplanin group or any mixture thereof and their use in preventing catheter related infections. These catheters are useful to prevent bacterial adherence and colonization and, therefore, to lower the risk of vascular infections in catheterized patients. The method of preparing the catheter of the invention consists in incubating polyurethane catheters coated with a hydrophilic film in an aqueous solution of the selected antibiotic.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: May 19, 1998
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Gabriella Romano', Beth P. Goldstein, Rosamund Jean Williams, Maurizio Denaro