Patents by Inventor Gabrielle Heilek

Gabrielle Heilek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SEQUENCING METHODS AND COMPOSITIONS FOR PRENATAL DIAGNOSES
    Publication number: 20240150828
    Abstract: The invention provides methods for determining aneuploidy and/or fetal fraction in maternal samples comprising fotal and matemal cfDNA by massively parallel sequencing. The method comprises a novel protocol for prepering sequencing libraries that unexpectedly improves the quality of library DNA while expediting the process of analysis of samples for prenatal diagnoses.
    Type: Application
    Filed: December 11, 2023
    Publication date: May 9, 2024
    Applicant: Verinata Health, Inc.
    Inventors: Richard P. Rava, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Brian Kent Rhees
  • Simultaneous determination of aneuploidy and fetal fraction
    Patent number: 11952623
    Abstract: The invention provides compositions and methods for simultaneously determining the presence or absence of fetal aneuploidy and the relative amount of fetal nucleic acids in a sample obtained from a pregnant female. The method encompasses the use of sequencing technologies and exploits the occurrence of polymorphisms to provide a streamlined noninvasive process applicable to the practice of prenatal diagnostics.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: April 9, 2024
    Assignee: VERINATA HEALTH, INC.
    Inventors: Stephen Quake, Richard P. Rava, Manjula Chinnappa, David A Comstock, Gabrielle Heilek
  • Sequencing methods and compositions for prenatal diagnoses
    Patent number: 11884975
    Abstract: The invention provides methods for determining aneuploidy and/or fetal fraction in maternal samples comprising fetal and maternal cfDNA by massively parallel sequencing. The method comprises a novel protocol for preparing sequencing libraries that unexpectedly improves the quality of library DNA while expediting the process of analysis of samples for prenatal diagnoses.
    Type: Grant
    Filed: March 5, 2021
    Date of Patent: January 30, 2024
    Assignee: VERINATA HEALTH, INC.
    Inventors: Richard P. Rava, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Brian Kent Rhees
  • SIMULTANEOUS DETERMINATION OF ANEUPLOIDY AND FETAL FRACTION
    Publication number: 20220017958
    Abstract: The invention provides compositions and methods for simultaneously determining the presence or absence of fetal aneuploidy and the relative amount of fetal nucleic acids in a sample obtained from a pregnant female. The method encompasses the use of sequencing technologies and exploits the occurrence of polymorphisms to provide a streamlined noninvasive process applicable to the practice of prenatal diagnostics.
    Type: Application
    Filed: September 2, 2021
    Publication date: January 20, 2022
    Applicant: Verinata Health, Inc.
    Inventors: Stephen Quake, Richard P. Rava, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek
  • SEQUENCING METHODS AND COMPOSITIONS FOR PRENATAL DIAGNOSES
    Publication number: 20210340613
    Abstract: The invention provides methods for determining aneuploidy and/or fetal fraction in maternal samples comprising fetal and maternal cfDNA by massively parallel sequencing. The method comprises a novel protocol for preparing sequencing libraries that unexpectedly improves the quality of library DNA while expediting the process of analysis of samples for prenatal diagnoses.
    Type: Application
    Filed: March 5, 2021
    Publication date: November 4, 2021
    Inventors: Richard P. Rava, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Brian Kent Rhees
  • Simultaneous determination of aneuploidy and fetal fraction
    Patent number: 11130995
    Abstract: The invention provides compositions and methods for simultaneously determining the presence or absence of fetal aneuploidy and the relative amount of fetal nucleic acids in a sample obtained from a pregnant female. The method encompasses the use of sequencing technologies and exploits the occurrence of polymorphisms to provide a streamlined noninvasive process applicable to the practice of prenatal diagnostics.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: September 28, 2021
    Assignee: Verinata Health, Inc.
    Inventors: Stephen Quake, Richard P Rava, Manjula Chinnappa, David A Comstock, Gabrielle Heilek
  • Sequencing methods and compositions for prenatal diagnoses
    Patent number: 10941442
    Abstract: The invention provides methods for determining aneuploidy and/or fetal fraction in maternal samples comprising fetal and maternal cfDNA by massively parallel sequencing. The method comprises a novel protocol for preparing sequencing libraries that unexpectedly improves the quality of library DNA while expediting the process of analysis of samples for prenatal diagnoses.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: March 9, 2021
    Assignee: Verinata Health, Inc.
    Inventors: Richard P. Rava, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Brian Kent Rhees
  • METHODS FOR DETERMINING FRACTION OF FETAL NUCLEIC ACIDS IN MATERNAL SAMPLES
    Publication number: 20200385810
    Abstract: The invention provides compositions and methods for determining the fraction of fetal nucleic acids in a maternal sample comprising a mixture of fetal and maternal nucleic acids. The fraction of fetal nucleic acids can be used in determining the presence or absence of fetal aneuploidy.
    Type: Application
    Filed: April 3, 2020
    Publication date: December 10, 2020
    Applicant: Verinata Health, Inc.
    Inventors: Richard P. Rava, Yue-Jen Chuu, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Michael Hunkapiller
  • Methods for determining fraction of fetal nucleic acids in maternal samples
    Patent number: 10612096
    Abstract: The invention provides compositions and methods for determining the fraction of fetal nucleic acids in a maternal sample comprising a mixture of fetal and maternal nucleic acids. The fraction of fetal nucleic acids can be used in determining the presence or absence of fetal aneuploidy.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: April 7, 2020
    Assignee: VERINATA HEALTH, INC.
    Inventors: Richard P. Rava, Yue-Jen Chuu, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Michael Hunkapiller
  • SIMULTANEOUS DETERMINATION OF ANEUPLOIDY AND FETAL FRACTION
    Publication number: 20170327883
    Abstract: The invention provides compositions and methods for simultaneously determining the presence or absence of fetal aneuploidy and the relative amount of fetal nucleic acids in a sample obtained from a pregnant female. The method encompasses the use of sequencing technologies and exploits the occurrence of polymorphisms to provide a streamlined noninvasive process applicable to the practice of prenatal diagnostics.
    Type: Application
    Filed: July 31, 2017
    Publication date: November 16, 2017
    Inventors: Stephen Quake, Richard P Rava, Manjula Chinnappa, David A Comstock, Gabrielle Heilek
  • SEQUENCING METHODS AND COMPOSITIONS FOR PRENATAL DIAGNOSES
    Publication number: 20170327881
    Abstract: The invention provides methods for determining aneuploidy and/or fetal fraction in maternal samples comprising fetal and maternal cfDNA by massively parallel sequencing. The method comprises a novel protocol for preparing sequencing libraries that unexpectedly improves the quality of library DNA while expediting the process of analysis of samples for prenatal diagnoses.
    Type: Application
    Filed: May 22, 2017
    Publication date: November 16, 2017
    Inventors: Richard P. Rava, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Brian Kent Rhees
  • Sequencing methods for prenatal diagnoses
    Patent number: 9657342
    Abstract: The invention provides methods for determining aneuploidy and/or fetal fraction in maternal samples comprising fetal and maternal cfDNA by massively parallel sequencing. The method comprises a novel protocol for preparing sequencing libraries that unexpectedly improves the quality of library DNA while expediting the process of analysis of samples for prenatal diagnoses.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: May 23, 2017
    Assignee: Verinata Health, Inc.
    Inventors: Richard P. Rava, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Brian Kent Rhees
  • METHODS FOR DETERMINING FRACTION OF FETAL NUCLEIC ACIDS IN MATERNAL SAMPLES
    Publication number: 20170037474
    Abstract: The invention provides compositions and methods for determining the fraction of fetal nucleic acids in a maternal sample comprising a mixture of fetal and maternal nucleic acids. The fraction of fetal nucleic acids can be used in determining the presence or absence of fetal aneuploidy.
    Type: Application
    Filed: October 20, 2016
    Publication date: February 9, 2017
    Applicant: VERINATA HEALTH, INC.
    Inventors: Richard P. Rava, Yue-Jen Chuu, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Michael Hunkapiller
  • Methods for determining fraction of fetal nucleic acids in maternal samples
    Patent number: 9493828
    Abstract: The invention provides compositions and methods for determining the fraction of fetal nucleic acids in a maternal sample comprising a mixture of fetal and maternal nucleic acids. The fraction of fetal nucleic acids can be used in determining the presence or absence of fetal aneuploidy.
    Type: Grant
    Filed: May 1, 2012
    Date of Patent: November 15, 2016
    Assignee: VERINATA HEALTH, INC.
    Inventors: Richard P. Rava, Yue-Jen Chuu, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Michael Hunkapiller
  • METHODS FOR DETERMINING FRACTION OF FETAL NUCLEIC ACIDS IN MATERNAL SAMPLES
    Publication number: 20120214678
    Abstract: The invention provides compositions and methods for determining the fraction of fetal nucleic acids in a maternal sample comprising a mixture of fetal and maternal nucleic acids. The fraction of fetal nucleic acids can be used in determining the presence or absence of fetal aneuploidy.
    Type: Application
    Filed: May 1, 2012
    Publication date: August 23, 2012
    Applicant: VERINATA HEALTH, INC.
    Inventors: RICHARD P. RAVA, YUE-JEN CHUU, MANJULA CHINNAPPA, DAVID A. COMSTOCK, GABRIELLE HEILEK, MICHAEL HUNKAPILLER
  • SIMULTANEOUS DETERMINATION OF ANEUPLOIDY AND FETAL FRACTION
    Publication number: 20120165203
    Abstract: The invention provides compositions and methods for simultaneously determining the presence or absence of fetal aneuploidy and the relative amount of fetal nucleic acids in a sample obtained form a pregnant female. The method encompasses the use of sequencing technologies and exploits the occurrence of polymorphisms to provide a streamlined noninvasive process applicable to the practice of prenatal diagnostics.
    Type: Application
    Filed: February 2, 2012
    Publication date: June 28, 2012
    Applicant: Verinata Health, Inc.
    Inventors: Stephen Quake, Richard P. Rava, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek
  • METHODS FOR DETERMINING FRACTION OF FETAL NUCLEIC ACIDS IN MATERNAL SAMPLES
    Publication number: 20120010085
    Abstract: The invention provides compositions and methods for determining the fraction of fetal nucleic acids in a maternal sample comprising a mixture of fetal and maternal nucleic acids. The fraction of fetal nucleic acids can be used in determining the presence or absence of fetal aneuploidy.
    Type: Application
    Filed: December 1, 2010
    Publication date: January 12, 2012
    Inventors: Richard P. RAVA, Yue-Jen CHUU, Manjula CHINNAPPA, David A. COMSTOCK, Gabrielle HEILEK, Michael HUNKAPILLER
  • SIMULTANEOUS DETERMINATION OF ANEUPLOIDY AND FETAL FRACTION
    Publication number: 20110224087
    Abstract: The invention provides compositions and methods for simultaneously determining the presence or absence of fetal aneuploidy and the relative amount of fetal nucleic acids in a sample obtained form a pregnant female. The method encompasses the use of sequencing technologies and exploits the occurrence of polymorphisms to provide a streamlined noninvasive process applicable to the practice of prenatal diagnostics.
    Type: Application
    Filed: December 1, 2010
    Publication date: September 15, 2011
    Inventors: Stephen Quake, Richard P. Rava, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek
  • SEQUENCING METHODS AND COMPOSITIONS FOR PRENATAL DIAGNOSES
    Publication number: 20110201507
    Abstract: The invention provides methods for determining aneuploidy and/or fetal fraction in maternal samples comprising fetal and maternal cfDNA by massively parallel sequencing. The method comprises a novel protocol for preparing sequencing libraries that unexpectedly improves the quality of library DNA while expediting the process of analysis of samples for prenatal diagnoses.
    Type: Application
    Filed: December 1, 2010
    Publication date: August 18, 2011
    Inventors: Richard P. Rava, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Brian Kent Rhees
  • Means and methods for monitoring non-nucleoside reverse transcriptase inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
    Publication number: 20020094522
    Abstract: This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) and further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy, particularly non-nucleoside reverse transcriptase inhibitor therapy using phenotypic susceptibility assays or genotypic assays.
    Type: Application
    Filed: September 14, 2001
    Publication date: July 18, 2002
    Inventors: Jeannette Whitcomb, Neil T. Parkin, Gabrielle Heilek-Snyder