Patents by Inventor GABRIELLE LECLERCQ

GABRIELLE LECLERCQ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PREVENTION OR MITIGATION OF NK CELL ENGAGING AGENT-RELATED ADVERSE EFFECTS
    Publication number: 20240058443
    Abstract: The present invention relates to the prevention or mitigation of adverse effects related to NK cell engaging agents, such as cytokine-related infusion reactions. Specifically, the invention relates to the prevention or mitigation of such side effects using an inhibitor of Src, JAK and/or mTOR.
    Type: Application
    Filed: October 20, 2023
    Publication date: February 22, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Hélène Cécile HAEGEL, Christian KLEIN, Gabrielle LECLERCQ, Alberto TOSO, Tina ZIMMERMANN
  • PREVENTION OR MITIGATION OF T-CELL ENGAGING AGENT-RELATED ADVERSE EFFECTS
    Publication number: 20230416412
    Abstract: The present invention relates to the prevention or mitigation of adverse effects related to T cell engaging agents, such as cytokine release syndrome. Specifically, the invention relates to the prevention or mitigation of such side effects using an inhibitor of NACHT, LRR and PYD domains-containing protein 3 (NLRP3).
    Type: Application
    Filed: May 26, 2023
    Publication date: December 28, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Gabrielle LECLERCQ-COHEN, Johannes SAM, Nathalie STEINHOFF, Pablo UMAÑA
  • PREVENTION OR MITIGATION OF T-CELL ENGAGING AGENT-RELATED ADVERSE EFFECTS
    Publication number: 20220168418
    Abstract: The present invention relates to the prevention or mitigation of adverse effects related to T cell engaging agents, such as cytokine release syndrome. Specifically, the invention relates to the prevention or mitigation of such side effects using an inhibitor of JAK and/or mTOR.
    Type: Application
    Filed: November 9, 2021
    Publication date: June 2, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Hélène Cécile HAEGEL, Christian KLEIN, Gabrielle LECLERCQ, Alberto TOSO, Tina ZIMMERMANN
  • Prevention or mitigation of T-cell bispecific antibody-related adverse effects
    Publication number: 20220088195
    Abstract: The present invention relates to the prevention or mitigation of adverse effects related to T cell bispecific antibodies, such as cytokine release syndrome. Specifically, the invention relates to the prevention or mitigation of such side effects using a tyrosine kinase inhibitor such as dasatinib.
    Type: Application
    Filed: September 24, 2021
    Publication date: March 24, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian Klein, Hélène Cécile Haegel, Alberto Toso, Gabrielle Leclercq, Tina Zimmermann
  • Methods for modulating protein galactosylation profiles of recombinant proteins using peracetyl galactose
    Patent number: 11118208
    Abstract: The present invention relates to methods and compositions for modulating glycosylation profile, such as the galactosylation profile, of recombinant proteins expressed by mammalian host cells during the cell culture process by supplementing cell culture media with a peracetyl galactose.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: September 14, 2021
    Assignee: ARES TRADING S.A.
    Inventors: Martin Jordan, Gabrielle Leclercq, Jonathan Souquet, Herve Broly, David Bruhlmann
  • METHODS FOR MODULATING PROTEIN GALACTOSYLATION PROFILES OF RECOMBINANT PROTEINS USING PERACETYL GALACTOSE
    Publication number: 20190153497
    Abstract: The present invention relates to methods and compositions for modulating glycosylation profile, such as the galactosylation profile, of recombinant proteins expressed by mammalian host cells during the cell culture process by supplementing cell culture media with a peracetyl galactose.
    Type: Application
    Filed: May 10, 2017
    Publication date: May 23, 2019
    Inventors: MARTIN JORDAN, GABRIELLE LECLERCQ, JONATHAN SOUQUET, HERVE BROLY, DAVID BRUHLMANN