Abstract: Methods for configuring a quantum annealer to solve a QUBO problem comprises receiving data representing an initial graph representing an embedding of a QUBO problem into a qubit architecture of the quantum annealer and causing one or more GPU thread blocks to create and store a best local current graph and update the best local current graph. Updating the best current local graph comprises copying the best local current graph, modifying the best local current graph copy to form a candidate local graph, computing an evaluation rating for the candidate local graph, and, in accordance with a determination that one or more replacement criteria are met, replacing the best local current graph with the candidate local graph. An updated best local current graph may be identified in a local results array as the best global graph. The quantum annealer may be configured based on the best local graph.