Patents by Inventor Gabrielle R. Neises

Gabrielle R. Neises has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Deoxygalactonojirimycin derivatives
    Patent number: 6291657
    Abstract: Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.
    Type: Grant
    Filed: August 5, 1993
    Date of Patent: September 18, 2001
    Assignee: Monsanto Company
    Inventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
  • Method of treating Tay-Sachs disease
    Patent number: 5801185
    Abstract: A method is disclosed for the treatment of Tay-Sachs disease comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
    Type: Grant
    Filed: January 13, 1997
    Date of Patent: September 1, 1998
    Assignee: Monsanto Company
    Inventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
  • Method for treatment of CNS-involved lysosomal storage diseases
    Patent number: 5798366
    Abstract: A method is disclosed for the in vivo treatment of patients having a lysosomal storage disease with a significant central nervous system (CNS) involvement. Said method comprises administration to said patient a small but storage-inhibitory effective amount of an N-alkyl derivative of a 1,5-iminosugar in which said alkyl group contains from about 2 to about 8 carbon atoms and said 1,5-iminosugar is 1,5-dideoxy-1,5-imino-D-glucitol, or 1,5-dideoxy-1,5-imino-D-galactitol, or an O-acylated pro-drug of said 1,5-iminosugar. In an illustrative example, CNS storage of GM2 ganglioside is inhibited in Tay-Sachs mice by administration of 1,5-(butylimino)-1,5-dideoxy-D-glucitol.
    Type: Grant
    Filed: January 13, 1997
    Date of Patent: August 25, 1998
    Assignee: Monsanto Company
    Inventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
  • Deoxygalactonojirimycin derivatives
    Patent number: 5786368
    Abstract: Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.
    Type: Grant
    Filed: January 17, 1996
    Date of Patent: July 28, 1998
    Assignee: Monsanto Company
    Inventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
  • Method of inhibiting the surface expression of glycolipid receptors for bacteria
    Patent number: 5786369
    Abstract: A method is disclosed for inhibiting the surface expression of glycolipid receptors for bacteria by subjecting bacteria cells to an inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
    Type: Grant
    Filed: May 20, 1996
    Date of Patent: July 28, 1998
    Assignee: Monsanto Company
    Inventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
  • Method of inhibiting glycolipid synthesis
    Patent number: 5656641
    Abstract: A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: August 12, 1997
    Assignee: Monsanto Company
    Inventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
  • Deoxygalactonojirimycin derivatives
    Patent number: 5580884
    Abstract: Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.
    Type: Grant
    Filed: March 1, 1995
    Date of Patent: December 3, 1996
    Assignee: Monsanto Company
    Inventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
  • Method of inhibiting glycolipid synthesis
    Patent number: 5525616
    Abstract: A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: June 11, 1996
    Assignee: Monsanto Company
    Inventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
  • Method of inhibiting glycolipid synthesis
    Patent number: 5472969
    Abstract: A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: December 5, 1995
    Assignee: Monsanto Company
    Inventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
  • Method of treating cholera
    Patent number: 5399567
    Abstract: This invention discloses a method of treating cholera infection in a human by administering an effective amount of 1,5-dideoxy-1,5-imino-D-glucitol or a derivative thereof.
    Type: Grant
    Filed: May 13, 1993
    Date of Patent: March 21, 1995
    Assignee: Monsanto Company
    Inventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters