Patents by Inventor Gad S. Cojocaru

Gad S. Cojocaru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATMENT OF DRUG RESISTANT MULTIPLE MYELOMA
    Publication number: 20150299333
    Abstract: This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages, wherein the cancer is relates to multiple myeloma, including multiple myeloma precursor diseases. This invention further relates to extracellular domains of TMEM154 proteins and variants, and therapeutic usages thereof.
    Type: Application
    Filed: February 27, 2015
    Publication date: October 22, 2015
    Applicant: COMPUGEN LTD.
    Inventors: Gad S. COJOCARU, Haiming CHEN, James BERENSON
  • SOLUBLE VEGFR-1 VARIANTS FOR DIAGNOSIS OF PREECLAMPSIA
    Publication number: 20150132318
    Abstract: Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same.
    Type: Application
    Filed: January 12, 2015
    Publication date: May 14, 2015
    Inventors: Osnat Sella-Tavor, Sarah Pollock, Gad S. Cojocaru, Amit Novik, Lily Bazak, Elena Tsypkin, Shira Wallach, Shirley Sameah-Greenwald
  • Compositions and methods for treatment of drug resistant multiple myeloma
    Patent number: 8999335
    Abstract: This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages, wherein the cancer is relates to multiple myeloma, including multiple myeloma precursor diseases. This invention further relates to extracellular domains of TMEM154 proteins and variants, and therapeutic usages thereof.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: April 7, 2015
    Assignee: Compugen Ltd.
    Inventors: Gad S. Cojocaru, Haiming Chen, James Berenson
  • LSR ANTIBODIES, AND USES THEREOF FOR TREATMENT OF CANCER
    Publication number: 20140294765
    Abstract: This invention relates to antibodies and antigen binding fragments and conjugates containing same, and/or alternative scaffolds, specific for LSR molecules, which are suitable drugs for immunotherapy and treatment of specific cancer.
    Type: Application
    Filed: June 19, 2013
    Publication date: October 2, 2014
    Applicant: COMPUGEN LTD.
    Inventors: Gad S. Cojocaru, Liat Dassa, Galit Rotman, Ofer Levi, Andrew Pow, Shirley Sameach-Greenwald, Zurit Levine
  • COMPOSITIONS AND METHODS FOR TREATMENT OF DRUG RESISTANT MULTIPLE MYELOMA
    Publication number: 20130266510
    Abstract: This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages, wherein the cancer is relates to multiple myeloma, including multiple myeloma precursor diseases. This invention further relates to extracellular domains of TMEM154 proteins and variants, and therapeutic usages thereof.
    Type: Application
    Filed: September 16, 2011
    Publication date: October 10, 2013
    Applicant: Compugen Ltd.
    Inventors: Gad S. Cojocaru, Haiming Chen, James Berenson
  • NOVEL HEPARANASE SPLICE VARIANT
    Publication number: 20120301475
    Abstract: The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.
    Type: Application
    Filed: November 30, 2010
    Publication date: November 29, 2012
    Inventors: Ronen Shemesh, Michal Ayalon-Soffer, Zurit Levine, Sergey Nemzer, Tomer Zekharya, Gad S. Cojocaru, Uri Barash, Neta Ilan, Israel Vlodavsky, Iris Hecht
  • VARIANTS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) RECEPTOR AND USE THEREOF
    Publication number: 20110212051
    Abstract: Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
    Type: Application
    Filed: February 28, 2011
    Publication date: September 1, 2011
    Inventors: Michal Ayalon-Soffer, Zurit Levine, Osnat Sella-Tavor, Alex Diber, Ronen Shemesh, Amir Toporik, Galit Rotman, Sergey Nemzer, Avi Rosenberg, Dvir Dahary, Assaf Wool, Gad S. Cojocaru, Pinchas Akiva, Sarah Pollock, Kinneret Savitsky, Jeanne Bernstein
  • Polynucleotides encoding polypeptides and methods using same
    Patent number: 7939634
    Abstract: Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: May 10, 2011
    Assignee: Compugen Ltd.
    Inventors: Michal Ayalon-Soffer, Zurit Levine, Osnat Sella-Tavor, Alex Diber, Ronen Shemesh, Amir Toporik, Galit Rotman, Sergey Nemzer, Avi Rosenberg, Dvir Dahary, Assaf Wool, Gad S. Cojocaru, Pinchas Akiva, Sarah Pollock, Kinneret Savitsky, Jeanne Bernstein
  • METHODS AND SYSTEMS FOR ANNOTATING BIOMOLECULAR SEQUENCES
    Publication number: 20110091454
    Abstract: Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.
    Type: Application
    Filed: February 8, 2010
    Publication date: April 21, 2011
    Inventors: Alex Diber, Sarah Pollock, Zurit Levine, Sergey Nemzer, Vladimir Grebinskiy, Brian Meloon, Andrew Olson, Avi Rosenberg, Ami Haviv, Shaul Zevin, Tomer Zekharia, Zipi Shaked, Moshe Olshansky, Ariel Farkash, Eyal Privman, Amit Novik, Naomi Keren, Gad S. Cojocaru, Pinchas Akiva, Yossi Cohen, Ronen Shemesh, Osnat Sella-Tavor, Liat Mintz, Hanqing Xie, Dvir Dahary, Erez Levanon, Shiri Freilich, Nili Beck, Wei-Yong Zhu, Alon Wasserman, Chen Chermesh, Idit Azar, Rotem Sorek, Jeanne Bernstein
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer
    Patent number: 7906635
    Abstract: Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: March 15, 2011
    Assignee: Compugen Ltd.
    Inventors: Gad S. Cojocaru, Sarah Pollock, Zurit Levine, Alexander Diber, Guy Kol, Amir Toporik, Rotem Sorek, Dvir Dahary, Michal Ayalon-Soffer, Pinchas Akiva, Amit Novik, Yossi Cohen, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Maxim Shklar
  • BIOMARKERS FOR THE PREDICTION OF RENAL INJURY
    Publication number: 20110003708
    Abstract: The present invention relates to means and methods for predicting the onset of renal injury based on measuring the expression of polynucleotides and proteins, particularly on measuring the expression of sets of novel as well as known polynucleotides and proteins, and to kits utilizing same.
    Type: Application
    Filed: June 25, 2010
    Publication date: January 6, 2011
    Applicant: COMPUGEN LTD.
    Inventors: Yaron Kinar, Merav Beiman, Eve Montia, Shira Walach, Tania Pergam, Amit Novik, Shirley Sameah-Greenwald, Gad S. Cojocaru, Anat Cohen-Dayag, Yael Furman
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
    Patent number: 7842459
    Abstract: Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: November 30, 2010
    Assignee: Compugen Ltd.
    Inventors: Michal Ayalon-Soffer, Sarah Pollock, Ronen Shemesh, Rotem Sorek, Zurit Levine, Zipi Shaqed, Amir Toporik, Gad S. Cojocaru, Dvir Dahary, Guy Kol, Pinchas Akiva, Amit Novik, Sergey Nemzer, Alexander Diber, Maxim Shklar, Osnat Sella-Tavor, Lily Bazak, Ariel Farkash, Yossi Cohen
  • Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of Use Thereof for Diagnosis of Cardiac Disease
    Publication number: 20100248270
    Abstract: Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
    Type: Application
    Filed: November 23, 2009
    Publication date: September 30, 2010
    Applicant: Compugen Ltd
    Inventors: Yossi Cohen, Alexander Diber, Amir Toporik, Sarah Pollock, Zurit Levine, Michal Ayalon-Soffer, Gad S. Cojocaru, Amit Novik, Guy Kol, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Dvir Dahary, Ronen Shemesh
  • Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of use Thereof for Diagnosis of Ovarian Cancer
    Publication number: 20100124786
    Abstract: Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
    Type: Application
    Filed: January 15, 2009
    Publication date: May 20, 2010
    Applicant: Compugen LTD
    Inventors: Gad S. Cojocaru, Sarah Pollock, Zurit Levine, Alexander Diber, Guy Kol, Amir Toporik, Rotem Sorek, Dvir Dahary, Michal Ayalon-Soffer, Pinchas Akiva, Amit Novik, Yossi Cohen, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Maxim Shklar
  • Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
    Publication number: 20100120022
    Abstract: Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
    Type: Application
    Filed: January 27, 2005
    Publication date: May 13, 2010
    Inventors: Michal Ayalon-Soffer, Sarah Pollock, Ronen Shemesh, Rotem Sorek, Zurit Levine, Zipi Shaqed, Amir Toporik, Gad S. Cojocaru, Dvir Dahary, Guy Kol, Pinchas Akiva, Amit Novik, Sergey Nemzer, Alexander Diber, Maxim Shklar, Osnat Sella-Tavor, Lily Bazak, Ariel Farkash, Yossi Cohen
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease
    Patent number: 7714100
    Abstract: Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: May 11, 2010
    Assignee: Compugen LTD
    Inventors: Yossi Cohen, Alexander Diber, Amir Toporik, Sarah Pollock, Zurit Levine, Michal Ayalon-Soffer, Gad S. Cojocaru, Amit Novik, Guy Kol, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Dvir Dahary, Ronen Shemesh
  • Novel polynucleotides encoding polypeptides and methods using same
    Publication number: 20100075891
    Abstract: Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
    Type: Application
    Filed: January 27, 2005
    Publication date: March 25, 2010
    Inventors: Michal Ayalon-Soffer, Zurit Levine, Osnat Sella-Tavor, Alex Diber, Ronen Shemesh, Amir Toporik, Galit Rotman, Sergey Nemzer, Avi Rosenberg, Dvir Dahary, Assaf Wool, Gad S. Cojocaru, Pinchas Akiva, Sarah Pollock, Kinneret Savitsky, Jeanne Bernstein
  • Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of Use Thereof for Diagnosis of Lung Cancer
    Publication number: 20100068736
    Abstract: Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.
    Type: Application
    Filed: September 10, 2009
    Publication date: March 18, 2010
    Applicant: Compugen LTD.
    Inventors: Sarah Pollock, Zurit Levine, Amit Novik, Dvir Dahary, Rotem Sorek, Amir Toporik, Shirley Sameah-Greenwald, Osnat Sella-Tavor, Alexander Diber, Gad S. Cojocaru, Michal Ayalon-Soffer, Shira Walach, Pinchas Akiva, Naomi Keren, Ronen Shemesh
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer
    Patent number: 7667001
    Abstract: Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: February 23, 2010
    Assignee: Compugen Ltd.
    Inventors: Sarah Pollock, Zurit Levine, Amit Novik, Dvir Dahary, Rotem Sorek, Amir Toporik, Shirley Sameah-Greenwald, Osnat Sella-Tavor, Alexander Diber, Gad S. Cojocaru, Michal Avalon-Soffer, Shira Walach, Pinchas Akiva, Naomi Keren, Ronen Shemesh
  • NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND ASSAYS AND METHODS OF USE THEREOF FOR DIAGNOSIS
    Publication number: 20090215042
    Abstract: Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same.
    Type: Application
    Filed: June 8, 2006
    Publication date: August 27, 2009
    Inventors: Osnat Sella-Tavor, Sarah Pollock, Gad S. Cojocaru, Amit Novik, Lily Bazak, Elena Tsypkin, Shira Wallach, Shirley Sameah-Greenwald