Patents by Inventor Gadi Turgeman
Gadi Turgeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140105871Abstract: Disclosed is the use of mesenchymal stem cells (MSCs) and in particular MSCs pretreated with pituitary adenylate cyclase-activating polypeptide (PACAP) or analogs and fragments of PACAP, for treatment of neurodegenerative and psychiatric diseases, and for the improvement of affective and cognitive function in a normal individual or in an individual suffering from a neurodegenerative or neuropsychiatric disease.Type: ApplicationFiled: November 19, 2013Publication date: April 17, 2014Applicant: Ariel University Research and Development Company, Ltd.Inventors: Gadi Turgeman, Matanel Tfilin, Nikoli Gobshtise
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Patent number: 8197553Abstract: A composite scaffold for engineering a heterogeneous tissue is provided. The composite scaffold includes: (a) a first scaffold being capable of supporting formation of a first tissue type thereupon; and (b) a second scaffold being capable of supporting formation of a second tissue type thereupon; wherein the first scaffold and the second scaffold are arranged with respect to each other such that when the first scaffold supports the first tissue type and the second scaffold supports the second tissue type, a distance between any cell of the second tissue type and the first tissue type does not exceed 200 ?m.Type: GrantFiled: September 29, 2008Date of Patent: June 12, 2012Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Dan Gazit, Abraham J. Domb, Gadi Turgeman, Gadi Pelled, Tony Azzam
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Publication number: 20110111505Abstract: The present invention describes methods of producing cell lines which express recombinant DNA encoding bone morphogenetic proteins (BMP). The cell lines are capable of being implanted in order to enhance the regeneration of tissues through both autocrine and paracrine effects. The cells may further contain DNA encoding receptor proteins which are able to bind to BMPs or enhance or regulate BMP activity.Type: ApplicationFiled: January 19, 2011Publication date: May 12, 2011Inventors: Ioannis MOUTSATSOS, Daniel Gazit, Yoram Zilberman, Gadi Turgeman
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Publication number: 20100209400Abstract: This invention is directed to methods, nucleic acids and compositions in TAK1-mediated regulation of SMAD activity. Promotion of TAK1 interaction with MH2 domains in SMADs negatively regulates SMAD biological activity. BMP-mediated SMAD activity is subject to TAK1 effects.Type: ApplicationFiled: November 30, 2009Publication date: August 19, 2010Inventors: Dan Gazit, Gadi Pelled, Gadi Turgeman, Andrea Hoffmann, Gerhard Gross, Claas Wodarczyk, Kristin Verschueren
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Patent number: 7504099Abstract: This invention provides method for repairing, regenerating, treating, or inducing the repair of an injury, a defect or a condition of a connective tissue of a subject. This invention provides a method of regenerating, enhancing, inducing repair and/or development of connective tissue as a result of a defect, injury or condition of the connective tissue of a subject comprising the step of inserting an engineered cell which comprises a nucleic acid encoding a SMAD protein or variant thereof, so as to induce regeneration, repair and/or development of the connective tissue. This invention further provides methods of ex-vivo implantation of engineered cells into an injury, defect or condition of the connective tissue. This invention also provides a nucleic acid encoding a SMAD 8 protein variant, cells comprising such SMAD 8 variant, include mesenchymal stem cells, progenitor cells or cells derived from a connective tissue. Lastly, this invention provides SMAD 8 protein variant.Type: GrantFiled: December 30, 2002Date of Patent: March 17, 2009Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Dan Gazit, Gadi Pelled, Gadi Turgeman, Andrea Hoffmann, Peter Eberle, Gerhard Gross
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Publication number: 20090035349Abstract: A composite scaffold for engineering a heterogeneous tissue is provided. The composite scaffold includes: (a) a first scaffold being capable of supporting formation of a first tissue type thereupon; and (b) a second scaffold being capable of supporting formation of a second tissue type thereupon; wherein the first scaffold and the second scaffold are arranged with respect to each other such that when the first scaffold supports the first tissue type and the second scaffold supports the second tissue type, a distance between any cell of the second tissue type and the first tissue type does not exceed 200 ?m.Type: ApplicationFiled: September 29, 2008Publication date: February 5, 2009Applicant: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Dan Gazit, Abraham Domb, Gadi Turgeman, Gadi Pelled, Tony Azzam
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Publication number: 20070197457Abstract: This invention is directed to methods, nucleic acids and compositions in TAK1-mediated regulation of SMAD activity. Promotion of TAK1 interaction with MH2 domains in SMADs negatively regulates SMAD biological activity. BMP-mediated SMAD activity is subject to TAK1 effects.Type: ApplicationFiled: March 29, 2004Publication date: August 23, 2007Inventors: Dan Gazit, Gadi Pelled, Gadi Turgeman, Andrea Hoffmann, Gerhard Gross, Claas Wodarczyk, Kristin Verschueren
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Publication number: 20060069053Abstract: The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell, which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector, which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition-comprising cell that expresses a factor of the T-box family, which includes inter-alia the brachyury.Type: ApplicationFiled: September 12, 2005Publication date: March 30, 2006Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem, Gesellschaft Fuer Biotechnologische Forschung mbH - GBFInventors: Dan Gazit, Yoram Zilberman, Gadi Turgeman, Gadi Pelled, Gerhard Gross, Andrea Hoffmann
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Patent number: 6849255Abstract: The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition comprising cell which expresses a factor of the T-box family, which includes inter-alia the brachyury.Type: GrantFiled: February 8, 2002Date of Patent: February 1, 2005Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Gesellschaft Fuer Biotechnologische Forschung MBHInventors: Dan Gazit, Yoram Zilberman, Gadi Turgeman, Gadi Pelled, Gerhard Gross, Stefan Czichos, Andrea Hoffmann
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Publication number: 20040009157Abstract: The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell, which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector, which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition-comprising cell that expresses a factor of the T-box family, which includes inter-alia the brachyury.Type: ApplicationFiled: November 18, 2002Publication date: January 15, 2004Inventors: Dan Gazit, Yoram Zilberman, Gadi Turgeman, Gadi Pelled, Gerhard Gross, Andrea Hoffmann
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Publication number: 20030228292Abstract: This invention provides method for repairing, regenerating, treating, or inducing the repair of an injury, a defect or a condition of a connective tissue of a subject. This invention provides a method of regenerating, enhancing, inducing repair and/or development of connective tissue as a result of a defect, injury or condition of the connective tissue of a subject comprising the step of inserting an engineered cell which comprises a nucleic acid encoding a SMAD protein or variant thereof, so as to induce regeneration, repair and/or development of the connective tissue. This invention further provides methods of ex-vivo implantation of engineered cells into an injury, defect or condition of the connective tissue. This invention also provides a nucleic acid encoding a SMAD 8 protein variant, cells comprising such SMAD 8 variant, include mesenchymal stem cells, progenitor cells or cells derived from a connective tissue. Lastly, this invention provides SMAD 8 protein variant.Type: ApplicationFiled: December 26, 2002Publication date: December 11, 2003Inventors: Dan Gazit, Gadi Pelled, Gadi Turgeman, Andrea Hoffmann, Peter Eberle, Gerhard Gross
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Publication number: 20030219423Abstract: This invention provides method for repairing, regenerating, treating, or inducing the repair of an injury, a defect or a condition of a connective tissue of a subject. This invention provides a method of regenerating, enhancing, inducing repair and/or development of connective tissue as a result of a defect, injury or condition of the connective tissue of a subject comprising the step of inserting an engineered cell which comprises a nucleic acid encoding a SMAD protein or variant thereof, so as to induce regeneration, repair and/or development of the connective tissue. This invention further provides methods of ex-vivo implantation of engineered cells into an injury, defect or condition of the connective tissue. This invention also provides a nucleic acid encoding a SMAD 8 protein variant, cells comprising such SMAD 8 variant, include mesenchymal stem cells, progenitor cells or cells derived from a connective tissue. Lastly, this invention provides SMAD 8 protein variant.Type: ApplicationFiled: December 30, 2002Publication date: November 27, 2003Inventors: Dan Gazit, Gadi Pelled, Gadi Turgeman, Andrea Hoffmann, Peter Eberle, Gerhard Gross
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Publication number: 20030185807Abstract: The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition comprising cell which expresses a factor of the T-box family, which includes inter-alia the brachyury.Type: ApplicationFiled: February 8, 2002Publication date: October 2, 2003Inventors: Dan Gazit, Yoram Zilberman, Gadi Turgeman, Gadi Pelled, Gerhard Gross, Stefan Czichos, Andrea Hoffmann
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Publication number: 20030068817Abstract: The invention relates to tubularized tissue, which in one embodiment is a vascular tissue made by seeding cells on the exterior surface of a scaffold and incubating of the cells so as to form a tubular tissue with the scaffold inside. In another embodiment the invention relates to a hybrid tissue. In another embodiment, the invention relates to methods of using the same for example, for enhancing blood vessel formation in a patient, for promoting angiogenesis and vasculogenesis, for replacing damaged blood vessel and for determining cellular or tissue function of an agent.Type: ApplicationFiled: September 5, 2002Publication date: April 10, 2003Inventors: Dan Gazit, Yossi Gafni, Gadi Turgeman, Gadi Pelled
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Publication number: 20020102728Abstract: The present invention describes methods of producing cell lines which express recombinant DNA encoding bone morphogenetic proteins (BMP). The cell lines are capable of being implanted in order to enhance the regeneration of tissues through both autocrine and paracrine effects. The cells may further contain DNA encoding receptor proteins which are able to bind to BMPs or enhance or regulate BMP activity.Type: ApplicationFiled: September 4, 1998Publication date: August 1, 2002Inventors: IOANNIS MOUTSATSOS, DAN GAZIT, YORAM ZILBERMAN, GADI TURGEMAN