Patents by Inventor Gael Ronsin

Gael Ronsin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDUSTRIAL PROCESS FOR THE PREPARATION OF HEXANOIC ACID, 6-(NITROOXY)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ETHYLAMINO)-7-OXO-2-HEPTEN-1-YL]-3,5-DIHYDROXYCYCLOPENTYL]-1-(2-PHENYLETHYL)-2-PROPEN-1-YL ESTER AND HIGH PURE PRODUCT
    Publication number: 20240018096
    Abstract: The present invention relates to a process for preparing hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]-3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester In accordance with the present invention, a pharmaceutical grade Compound (I) can be efficiently prepared by a one-pot reactions preparation step that includes the esterification of the 15-OH bimatoprost by coupling bimatoprost phenyl-boronate with 6-(nitrooxy)hexanoic acid and the removal of the boronate ester protecting group, followed by an efficient purification step. The invention refers also to high purity Compound (I) substantially free of the impurity 15-(6-chlorohexanoyl) ester of bimatoprost and to ophthalmic pharmaceutical formulations containing the high purity compound.
    Type: Application
    Filed: July 6, 2023
    Publication date: January 18, 2024
    Inventors: Szabolcs KOVÁCS, Andrea Sántáné Csutor, Irén Hortobágyi, Judit Póti, Gael Ronsin, Nicoletta Almirante
  • Quinone based nitric oxide donating compounds for ophthalmic use
    Patent number: 9598349
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: March 21, 2017
    Assignee: Nicox Science Ireland
    Inventors: Nicoletta Almirante, Laura Storoni, Gael Ronsin, Elena Bastia
  • QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE
    Publication number: 20160145192
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.
    Type: Application
    Filed: April 14, 2014
    Publication date: May 26, 2016
    Inventors: Nicoletta ALMIRANTE, Laura STORONI, Gael RONSIN, Elena BASTIA
  • Quinone based nitric oxide donating compounds
    Patent number: 9079821
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: July 14, 2015
    Assignee: NICOX SCIENCE IRELAND
    Inventors: Gael Ronsin, Laura Storoni, Francesca Benedini
  • Quinone based nitric oxide donating compounds
    Patent number: 9061962
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: June 23, 2015
    Assignee: Nicox Science Ireland
    Inventors: Gael Ronsin, Laura Storoni, Francesca Benedini
  • QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS
    Publication number: 20140342998
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
    Type: Application
    Filed: October 23, 2012
    Publication date: November 20, 2014
    Applicant: NICOX S.A.
    Inventors: Gael Ronsin, Laura Storoni, Francesca Benedini
  • QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS
    Publication number: 20140135389
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
    Type: Application
    Filed: January 22, 2014
    Publication date: May 15, 2014
    Inventors: Gael RONSIN, Laura STORONI, Francesca BENEDINI
  • Compositions derived from quinoline and quinoxaline, preparation and use thereof
    Publication number: 20060183909
    Abstract: The present invention concerns compounds derived from quinoline and quinoxaline, their preparation and their uses, particularly in the field of therapeutics and vaccines or for developing active compounds. The inventive compounds are of general formula (I), and their pharmaceutically acceptable salts.
    Type: Application
    Filed: July 19, 2002
    Publication date: August 17, 2006
    Inventors: Martine Schmitt, Evelyne Klotz, Jean-Paul Macher, Jean-Jacques Bourguignon, Mustapha Abarghaz, Patrick Wagner, Gael Ronsin
  • Diaminoacid-aminoacid-polyamine based gemini surfactant compounds
    Publication number: 20060148734
    Abstract: Diaminoacid-polyamine:peptide-based gemini compounds are disclosed. The compounds are based on diaminoacid-polyamine or diaminoacid-aminoacid-polyamine backbone with peptide groups and optionally hydrocarboxyl groups linked thereto. Uses of the diaminoacid-polyamine:peptide-based gemini compounds and methods for their production are also disclosed.
    Type: Application
    Filed: March 26, 2003
    Publication date: July 6, 2006
    Inventors: Patrick Camilleri, Martinus Feiters, Anthony Kirby, Gael Ronsin, Roeland Nolte, Cristina Garcia