Patents by Inventor Gaelle Saintigny
Gaelle Saintigny has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230227503Abstract: Polypeptides belonging to the family of late proteins of the cornified envelope (LCE), fragments of the polypeptide, isolated nucleotide sequences encoding the polypeptides, and cosmetic and/or pharmaceutical compositions containing such polypeptides are described. The polypeptides have cosmetic and/or therapeutic use to reinforce the barrier function of the epidermis, prevent and/or treat the signs of skin dryness and prevent and/or treat disorders of the barrier function or the weakening of the epidermis.Type: ApplicationFiled: September 20, 2022Publication date: July 20, 2023Inventors: Nathalie JONCA, Eve TOULZA, Gaelle SAINTIGNY, Guy SERRE, Marina WEBER VIVAT
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Patent number: 11479580Abstract: Polypeptides belonging to the family of late proteins of the cornified envelope (LCE), fragments of the polypeptide, isolated nucleotide sequences encoding the polypeptides, and cosmetic and/or pharmaceutical compositions containing such polypeptides are described. The polypeptides have cosmetic and/or therapeutic use to reinforce the barrier function of the epidermis, prevent and/or treat the signs of skin dryness and prevent and/or treat disorders of the barrier function or the weakening of the epidermis.Type: GrantFiled: September 21, 2018Date of Patent: October 25, 2022Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE PAUL SABATIER TOULOUSE IIIInventors: Nathalie Jonca, Eve Toulza, Gaelle Saintigny, Guy Serre, Marina Weber Vivat
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Patent number: 10837058Abstract: An in vitro method for screening for candidate compounds for preventing and/or attenuating skin ageing, and/or hydrating skin, includes: a) contacting a test compound with a sample of papillary fibroblasts; b) measuring the expression of a gene selected from PDPN, CCRL1 and NTN1, in the papillary fibroblasts; and c) selecting compounds for which an activation of at least 1.5 fold of the expression of at least one of the genes is measured in the treated papillary fibroblasts compared with untreated papillary fibroblasts. Another in vitro method includes: a) contacting a test compound with a sample of reticular fibroblasts; b) measuring the expression of a gene selected from MGP, PPP1R14A and TGM2, in the reticular fibroblasts; and c) selecting compounds for which an activation of at most 1.0 fold of the expression of at least one of the genes is measured in the treated reticular fibroblasts compared with untreated reticular fibroblasts.Type: GrantFiled: November 23, 2012Date of Patent: November 17, 2020Assignees: CHANEL PARFUMS BEAUTE, LEIDEN UNIVERSITY MEDICAL CENTERInventors: Gaelle Saintigny, Abdelouahab Elghalbzouri
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Publication number: 20190010191Abstract: Polypeptides belonging to the family of late proteins of the cornified envelope (LCE), fragments of the polypeptide, isolated nucleotide sequences encoding the polypeptides, and cosmetic and/or pharmaceutical compositions containing such polypeptides are described. The polypeptides have cosmetic and/or therapeutic use to reinforce the barrier function of the epidermis, prevent and/or treat the signs of skin dryness and prevent and/or treat disorders of the barrier function or the weakening of the epidermis.Type: ApplicationFiled: September 21, 2018Publication date: January 10, 2019Inventors: Nathalie JONCA, Eve TOULZA, Gaelle SAINTIGNY, Guy SERRE, Marina WEBER VIVAT
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Publication number: 20180216182Abstract: Disclosed is a method for identification and use of compounds which activate the expression or activity of uc.291 for improving skin barrier function, and/or for preventing and/or attenuating ageing, and/or for hydrating skin. The disclosed in vitro method for screening for candidate compounds for improving skin barrier function, and/or for preventing and/or attenuating ageing of the skin, and/or for hydrating the skin, includes: a. bringing at least one test compound in contact with a sample of keratinocytes; b. measuring the expression or the activity of uc.291 in the keratinocytes; and c. selecting the compounds for which an activation of at least 20%, preferably at least 30%, preferably at least 40% of the expression or an activation of at least 20%, preferably at least 30%, preferably at least 40% of the activity of uc.291 is measured in the keratinocytes treated in a. compared with the untreated keratinocytes.Type: ApplicationFiled: July 26, 2016Publication date: August 2, 2018Inventors: Eleonora CANDI, Gerry MELINO, Gaelle SAINTIGNY, Christian MAHE
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Publication number: 20170260235Abstract: Polypeptides belonging to the family of late proteins of the cornified envelope (LCE), fragments of the polypeptide, isolated nucleotide sequences encoding the polypeptides, and cosmetic and/or pharmaceutical compositions containing such polypeptides are described. The polypeptides have cosmetic and/or therapeutic use to reinforce the barrier function of the epidermis, prevent and/or treat the signs of skin dryness and prevent and/or treat disorders of the barrier function or the weakening of the epidermis.Type: ApplicationFiled: March 2, 2017Publication date: September 14, 2017Inventors: Nathalie JONCA, Eve TOULZA, Gaelle SAINTIGNY, Guy SERRE, Marina WEBER VIVAT
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Patent number: 9617307Abstract: Polypeptides belonging to the family of late proteins of the cornified envelope (LCE), fragments of the polypeptide, isolated nucleotide sequences encoding the polypeptides, and cosmetic and/or pharmaceutical compositions containing such polypeptides are described. The polypeptides have cosmetic and/or therapeutic use to reinforce the barrier function of the epidermis, prevent and/or treat the signs of skin dryness and prevent and/or treat disorders of the barrier function or the weakening of the epidermis.Type: GrantFiled: June 11, 2015Date of Patent: April 11, 2017Assignees: UNIVERSITE PAUL SABATIER (TOULOUSE III), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Nathalie Jonca, Eve Toulza, Gaelle Saintigny, Guy Serre, Marina Weber Vivat
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Patent number: 9568467Abstract: Identification and use of compounds which inhibit the expression or activity of micro-RNAs for preventing and/or attenuating ageing. An in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin including (a) bringing at least one test compound in contact with a sample of fibroblasts, (b) measuring the expression or the activity of at least one microRNA chosen from miR-134 and miR-152 in said fibroblasts, and (c) selecting the compounds for which an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the expression or an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the activity of at least one microRNA is measured in the fibroblasts treated in (a) compared with the untreated fibroblasts.Type: GrantFiled: August 28, 2013Date of Patent: February 14, 2017Assignee: CHANEL PARFUMS BEAUTEInventors: Eleonora Candi, Gerry Melino, Gaelle Saintigny, Christian Mahe
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Patent number: 9410152Abstract: At least one microRNA selected from among hsa-miR-330, hsa-miR-7 and hsa-miR-137, the mature forms thereof, and the precursors thereof, for depigmenting the skin, and an in vitro method for identifying depigmenting compounds, which includes the steps of: a) placing at least one test compound in contact with a sample of melanocytes; b) measuring the expression or activity of at least one microRNA selected from among miR-330, miR-7 and miR-137, the mature forms thereof, and the precursors thereof, in the melanocytes; c) selecting the compounds for which at least 20% activation of the expression or of the activity of at least one of the microRNAs is measured in the melanocytes treated in a) by an element for comparing with the untreated melanocytes.Type: GrantFiled: December 18, 2012Date of Patent: August 9, 2016Assignees: CHANEL PARFUMS BEAUTE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRSInventors: Gaelle Saintigny, Christian Mahe, Lionel Larue, Florian Rambow
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Publication number: 20150299260Abstract: Polypeptides belonging to the family of late proteins of the cornified envelope (LCE), fragments of the polypeptide, isolated nucleotide sequences encoding the polypeptides, and cosmetic and/or pharmaceutical compositions containing such polypeptides are described. The polypeptides have cosmetic and/or therapeutic use to reinforce the barrier function of the epidermis, prevent and/or treat the signs of skin dryness and prevent and/or treat disorders of the barrier function or the weakening of the epidermis.Type: ApplicationFiled: June 11, 2015Publication date: October 22, 2015Inventors: Nathalie JONCA, Eve TOULZA, Gaelle SAINTIGNY, Guy SERRE, Marina WEBER VIVAT
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Patent number: 9096852Abstract: Method of identifying and using compounds which inhibit the expression or activity of micro-RNAs for preventing and/or attenuating ageing, and/or for hydrating skin. An in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin, and/or for hydrating the skin, includes the following steps: a. bringing at least one test compound in contact with a sample of keratinocytes; b. measuring the expression or the activity of at least one microRNA in the keratinocytes; c. selecting the compounds for which an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the expression or an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the activity of at least one microRNA is measured in the keratinocytes treated in a. compared with the untreated keratinocytes.Type: GrantFiled: June 7, 2011Date of Patent: August 4, 2015Assignee: CHANEL PARFUMS BEAUTEInventors: Eleonora Candi, Gennaro Melino, Gaelle Saintigny, Christian Mahe
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Patent number: 9085635Abstract: A novel polypeptide isolated from the cornified envelope, similar polypeptides and fragments of the polypeptide, isolated nucleotide sequences encoding the polypeptides, as well as a cosmetic and/or pharmaceutical composition containing such polypeptides are described. The polypeptides have cosmetic and/or therapeutic use to reinforce the barrier function of the epidermis, prevent and/or treat the signs of skin dryness and prevent and/or treat disorders of the barrier function or the weakening of the epidermis.Type: GrantFiled: April 27, 2011Date of Patent: July 21, 2015Assignees: CHANEL PARFUMS BEAUTE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITE PAUL SABATIER TOULOUSE IIIInventors: Nathalie Jonca, Eve Toulza, Gaelle Saintigny, Guy Serre, Marina Weber Vivat
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Publication number: 20150010485Abstract: At least one microRNA selected from among hsa-miR-330, hsa-miR-7 and hsa-miR-137, the mature forms thereof, and the precursors thereof, for depigmenting the skin, and an in vitro method for identifying depigmenting compounds, which includes the steps of: a) placing at least one test compound in contact with a sample of melanocytes; b) measuring the expression or activity of at least one microRNA selected from among miR-330, miR-7 and miR-137, the mature forms thereof, and the precursors thereof, in the melanocytes; c) selecting the compounds for which at least 20% activation of the expression or of the activity of at least one of the microRNAs is measured in the melanocytes treated in a) by an element for comparing with the untreated melanocytes.Type: ApplicationFiled: December 18, 2012Publication date: January 8, 2015Applicants: CHANEL PARFUMS BEAUTE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), INSTITUTE CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRSInventors: Gaelle Saintigny, Christian Mahe, Lionel Larue, Florian Rambow
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Publication number: 20140323345Abstract: An in vitro method for screening for candidate compounds for preventing and/or attenuating skin ageing, and/or hydrating skin, includes: a) contacting a test compound with a sample of papillary fibroblasts; b) measuring the expression of a gene selected from PDPN, CCRL1 and NTN1, in the papillary fibroblasts; and c) selecting compounds for which an activation of at least 1.5 fold of the expression of at least one of the genes is measured in the treated papillary fibroblasts compared with untreated papillary fibroblasts. Another in vitro method includes: a) contacting a test compound with a sample of reticular fibroblasts; b) measuring the expression of a gene selected from MGP, PPP1R14A and TGM2, in the reticular fibroblasts; and c) selecting compounds for which an activation of at most 1.0 fold of the expression of at least one of the genes is measured in the treated reticular fibroblasts compared with untreated reticular fibroblasts.Type: ApplicationFiled: November 23, 2012Publication date: October 30, 2014Applicants: LEIDEN UNIVERSITY MEDICAL CENTER, CHANEL PARFUMS BEAUTEInventors: Gaelle Saintigny, Abdelouahab Elghalbzouri
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Publication number: 20140065250Abstract: Identification and use of compounds which inhibit the expression or activity of micro-RNAs for preventing and/or attenuating ageing. An in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin including (a) bringing at least one test compound in contact with a sample of fibroblasts, (b) measuring the expression or the activity of at least one microRNA chosen from miR-134 and miR-152 in said fibroblasts, and (c) selecting the compounds for which an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the expression or an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the activity of at least one microRNA is measured in the fibroblasts treated in (a) compared with the untreated fibroblasts.Type: ApplicationFiled: August 28, 2013Publication date: March 6, 2014Applicant: CHANEL PARFUMS BEAUTEInventors: Eleonora CANDI, Gerry MELINO, Gaelle SAINTIGNY, Christian MAHE
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Patent number: 8440624Abstract: The present invention relates to novel peptide compounds having the following formula [R1R2N—CH(Ra)—CO]a-(AA1)m-(AA2)b-X1—X2—X3—Y1—Y2—Y3—X4-(AA3)n-[NH—CH(Rb)—COOR3]c. It also pertains to cosmetic and dermatological compositions comprising one or more of these peptide compounds and to their uses in the cosmetic whitening of human skin and for the manufacture of a dermatological preparation intended to depigment human skin.Type: GrantFiled: June 16, 2008Date of Patent: May 14, 2013Assignee: Chanel Parfums BeauteInventors: Stefan Honing, Gaelle Saintigny
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Publication number: 20130071370Abstract: Method of identifying and using compounds which inhibit the expression or activity of micro-RNAs for preventing and/or attenuating ageing, and/or for hydrating skin. An in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin, and/or for hydrating the skin, includes the following steps: a. bringing at least one test compound in contact with a sample of keratinocytes; b. measuring the expression or the activity of at least one microRNA in the keratinocytes; c. selecting the compounds for which an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the expression or an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the activity of at least one microRNA is measured in the keratinocytes treated in a. compared with the untreated keratinocytes.Type: ApplicationFiled: June 7, 2011Publication date: March 21, 2013Applicant: CHANEL PARFUMS BEAUTEInventors: Eleonora Candi, Gennaro Melino, Gaelle Saintigny, Christian Mahe
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Publication number: 20130053327Abstract: A novel polypeptide isolated from the cornified envelope, polypeptides similar to the latter or fragments of the polypeptide as well as a cosmetic and/or pharmaceutical composition containing same are described. The mainly cosmetic and/or therapeutic use of the polypeptide, or similar polypeptides or fragments of the amino acid sequence of the polypeptide, or an encoding nucleotide sequence for the polypeptide, to reinforce the barrier function of the epidermis and prevent and/or treat the signs of skin dryness or prevent and/or treat disorders of the barrier function or the fragilisation of the epidermis. Finally, the isolated encoding polynucleotide for the polypeptide are also disclosed.Type: ApplicationFiled: April 27, 2011Publication date: February 28, 2013Applicants: CHANEL PARFUMS BEAUTE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S. ), UNIVERSITE PAUL SABATIER TOULOUSE IIIInventors: Nathalie Jonca, Eve Toulza, Gaelle Saintigny, Guy Serre, Marina Weber Vivat
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Patent number: 8142825Abstract: A cosmetic skincare process intended to prevent and/or treat at least one cutaneous sign of aging, includes the topical application to the skin of a composition containing at least one active agent capable of stimulating tensin 1 expression. The cosmetic use of an active agent capable of stimulating tensin 1 expression, for preventing and/or treating at least one cutaneous sign of aging, an extract of elemi or of Canarium indicum L. or of Canarium luzonicum or of Canarium commune and a cosmetic composition containing the extract are also disclosed.Type: GrantFiled: June 10, 2011Date of Patent: March 27, 2012Assignee: Chanel Parfums BeauteInventors: Yannick Maestro, Gaëlle Saintigny, François Xavier Bernard
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Publication number: 20110281274Abstract: A cosmetic skincare process intended to prevent and/or treat at least one cutaneous sign of aging, includes the topical application to the skin of a composition containing at least one active agent capable of stimulating tensin 1 expression. The cosmetic use of an active agent capable of stimulating tensin 1 expression, for preventing and/or treating at least one cutaneous sign of aging, an extract of elemi or of Canarium indicum L. or of Canarium luzonicum or of Canarium commune and a cosmetic composition containing the extract are also disclosed.Type: ApplicationFiled: June 10, 2011Publication date: November 17, 2011Applicant: CHANEL PARFUMS BEAUTEInventors: Yannick MAESTRO, Gaelle Saintigny, Francois Xavier Bernard