Patents by Inventor Gaetan Ladouceur

Gaetan Ladouceur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diaryl ureas for diseases mediated by PDGFR
    Patent number: 8796250
    Abstract: The present invention provides methods for treating and/or preventing conditions and diseases in humans and other mammals that are associated with and/or mediated by signal transduction pathways comprising platelet-derived growth factor receptor (PDGFR) by administering diaryl ureas of Formula I. The present invention also provides devices and methods for treating, ameliorating, preventing, or modulating restenosis following angioplastic surgery or other invasive procedures that affect or injure the vascular system, and graft rejection following transplantation of a donor tissue into a host, where a stent or other omplantable device comprises an effective amount of diaryl ureas of Formula I.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: August 5, 2014
    Assignee: Bayer Healthcare LLC
    Inventors: Scott Wilhelm, Jacques Dumas, Gaetan Ladouceur, Mark Lynch, William Scott
  • Tetrahydropyridothienopyrimidine compounds and methods of use thereof
    Patent number: 8501755
    Abstract: This invention relates to compounds of Formula (I), wherein the variables are as disclosed in the specification, to pharmaceutical compositions containing them, to methods of making the compounds and pharmaceutical compositions, and to methods of using the compounds and pharmaceutical compositions for treating or preventing disorders, in particular cancer.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: August 6, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Chengzhi Zhang, Kanwar Sidhu, Mario Lobell, Gaetan Ladouceur, Qian Zhao, Zheng Liu, Kristen M. Allegue, Chetan P. Darne, Jason Newcom
  • Substituted pyrazolyl urea derivatives useful in the treatment of cancer
    Patent number: 8207166
    Abstract: The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: June 26, 2012
    Assignee: Bayer Healthcare LLC
    Inventors: Wendy Lee, Gaetan Ladouceur, Jacques Dumas, Roger Smith, Shihong Ying, Gan Wang, Zhi Chen, Qingjie Liu, Holia Mokdad
  • Substituted Pyrazole Compounds
    Publication number: 20110318393
    Abstract: Provided are substituted pyrazole compounds which are useful as protein kinase inhibitors, compositions comprising the compounds, and methods of use thereof. The protein kinase inhibitors are particularly for inhibition of Aurora A (Aurora-2) protein kinase and are useful in the treatment of diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.
    Type: Application
    Filed: November 23, 2009
    Publication date: December 29, 2011
    Applicant: MIIKANA THERAPEUTICS, INC.
    Inventors: Gaetan Ladouceur, Gregory A. Agosto, Jamshed H. Shah, Lita Suwandi, Nnamdi Ofoegbu
  • UREA COMPOUNDS USEFUL IN THE TREATMENT OF CANCER
    Publication number: 20110195110
    Abstract: Pyrazole urea compounds, pharmaceutical compositions which contain them and methods for treating cancer using them.
    Type: Application
    Filed: December 1, 2006
    Publication date: August 11, 2011
    Inventors: Roger Smith, Holia N. Hatoum-Mokdad, Louis David Cantin, Donald E. Bierer, Wenlang Fu, Dhanapalan Nagarathnam, Gaetan Ladouceur, Yamin Wang, Herbert Ogutu, Scot Wilhelm, Ian Taylor, Sanjeeva Reddy, Richard Gedrich, Christopher Carter, Aaron Schmitt, Xiaomei Zhang
  • Substituted Pyrazolyl Urea Derivatives Useful In The Treatment Of Cancer
    Publication number: 20110136809
    Abstract: The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
    Type: Application
    Filed: November 8, 2010
    Publication date: June 9, 2011
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Wendy LEE, Gaetan LADOUCEUR, Jacques DUMAS, Roger SMITH, Shihong YING, Gan WANG, Zhi CHEN, Qingjie LIU, Holia Hatoum MOKDAD
  • Substituted pyrazolyl urea derivatives useful in the treatment of cancer
    Patent number: 7838524
    Abstract: The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
    Type: Grant
    Filed: May 2, 2005
    Date of Patent: November 23, 2010
    Assignee: Bayer Healthcare LLC
    Inventors: Wendy Lee, Gaetan Ladouceur, Jacques Dumas, Roger Smith, Shihong Ying, Gan Wang, Zhi Chen, Qingjie Liu, Holia Hatoum Mokdad
  • Benzofuran derivatives useful for treating hyper-proliferative disorders
    Patent number: 7659412
    Abstract: The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: February 9, 2010
    Assignee: Bayer Healthcare LLC
    Inventors: Chengzhi Zhang, Jacques Dumas, Gaetan Ladouceur, Qian Zhao, Martin Hentemann, Sharad Verma, Qingming Zhu, Rico Lavoie, Jianmei Fan, Barton Phillips
  • Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
    Patent number: 7585888
    Abstract: This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: September 8, 2009
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Michael J. Burke, Zhi Chen, Jacques P. Dumas, Dongping Fan, Jianmei Fan, Holia Hatoum-Mokdad, Benjamin D. Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips
  • FUROPYRIDINE AND FUROPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS
    Publication number: 20090143412
    Abstract: This invention relates to a compound of Formula I wherein Y is CH or N; Ar1 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each selected independently from (C1-C3)alkoxy, halo, OH, CF3, CN, NO2 and (C1-C3)alkyl, said alkyl being optionally substituted with CF3; Ar2 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each independently selected from halo, OH, CN, NO2, CF3, (C1-C6)alkoxy, NR1R1, S(O)2R2, C(O)R3, and (C1-C6)alkyl optionally substituted with R4, and its use in treating hyper-proliferative disorder.
    Type: Application
    Filed: September 26, 2008
    Publication date: June 4, 2009
    Applicant: Bayer HealthCare LLC
    Inventors: Chengzhi Zhang, Gaetan Ladouceur, Michael J. Burke
  • BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS
    Publication number: 20090054514
    Abstract: This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.
    Type: Application
    Filed: March 31, 2008
    Publication date: February 26, 2009
    Inventors: Chengzhi ZHANG, Michael BURKE, Zhi CHEN, Jacques DUMAS, Dongping FAN, Jianmei FAN, Holia HATOUM-MOKDAD, Benjamin JONES, Gaetan LADOUCEUR, Wendy LEE, Barton PHILLIPS
  • SUBSTITUTED PYRAZOLE COMPOUNDS
    Publication number: 20090029992
    Abstract: Disclosed are protein kinase inhibitors, compositions comprising such inhibitors, and methods of use thereof. More particularly, disclosed are inhibitors of Aurora A (Aurora-2) protein kinase. Also disclosed are methods of treating diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.
    Type: Application
    Filed: June 11, 2008
    Publication date: January 29, 2009
    Inventors: GREGORY E. AGOSTON, Anthony M. Treston, Gaetan Ladouceur, Lita Suwandi
  • Furo[2.3-b]pyridine derivatives for the treatment of hyper-proliferative disorders
    Patent number: 7429584
    Abstract: This invention relates to a compound of Formula (I) wherein Y is CH or N; Ar1 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each selected independently from (C1-C3)alkoxy halo, OH, CF3, CN, NO2 and (C1-C3)alkyl, said alkyl being optionally substituted with CF3; Ar2 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each independently selected from halo, OH, CN, NO2, CF3, (C1-C6)alkoxy, NR1R1, S(O)2R2, C(O)R3, and (C1-C6)alkyl optionally substituted with R4, and its use in treating hyper-proliferative disorders.
    Type: Grant
    Filed: July 11, 2003
    Date of Patent: September 30, 2008
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Gaetan Ladouceur, Michael J. Burke
  • Substituted Pyrazolyl Urea Derivatives Useful in the Treatment of Cancer
    Publication number: 20080214545
    Abstract: The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
    Type: Application
    Filed: May 2, 2005
    Publication date: September 4, 2008
    Inventors: Wendy Lee, Gaetan Ladouceur, Jacques Dumas, Roger Smith, Shihong Ying, Gan Wang, Zhi Chen, Qingjie Liu, Holia Hatoum Mokdad
  • Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
    Patent number: 7384947
    Abstract: This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: June 10, 2008
    Assignee: Bayer HealthCare LLC
    Inventors: Chengzhi Zhang, Michael Burke, Zhi Chen, Jacques Dumas, Dongping Fan, Benjamin D. Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips, Scott M. Wilhelm, Qian Zhao
  • Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
    Patent number: 7351735
    Abstract: This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: April 1, 2008
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Michael Burke, Zhi Chen, Jacques Dumas, Dongping Fan, Jianmei Fan, Holia Hatoum-Mokdad, Benjamin D. Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips
  • Indolyl-thienopyrazinone derivatives useful for treating hyperproliferative disorders and diseases associated with angiogenesis
    Publication number: 20070105851
    Abstract: This invention relates to a compound of Formula (I): (I) and its use in treating hyper-proliferative disorders and diseases associated with angiogenesis.
    Type: Application
    Filed: November 4, 2004
    Publication date: May 10, 2007
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: James Cook, Cheng Bi, Gaetan Ladouceur
  • Diaryl ureas with kinase inhibiting activity
    Publication number: 20070020704
    Abstract: The present invention provides methods of using aryl ureas to treat diseases and conditions associated with signal transduction pathways comprising at least one of raf, VEGFR, PDGFR, p38 and/or FLT-3. The present invention also provides compositions and methods for identifying conditions and diseases which can be modulated with compounds of the present invention. These methods facilitate the selection of subjects who can be efficiently treated with compounds of the present invention. Additionally, the invention provides methods for monitoring subjects who have been administered a compound of the present invention.
    Type: Application
    Filed: May 19, 2004
    Publication date: January 25, 2007
    Inventors: Scott Wilhelm, Jacques Dumas, Gaetan Ladouceur, Mark Lynch, William Scott
  • Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders
    Publication number: 20060293322
    Abstract: The present invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders.
    Type: Application
    Filed: July 23, 2004
    Publication date: December 28, 2006
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Gaetan Ladouceur, Catherine Brennan, Brent Chandler, Julie Dizon, Karl Miranda, Dongping Fan, Qingming Zhu, Sharad Verma, Jacques Dumas
  • Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
    Publication number: 20060287387
    Abstract: This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.
    Type: Application
    Filed: August 28, 2006
    Publication date: December 21, 2006
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Michael Burke, Zhi Chen, Jacques Dumas, Dongping Fan, Benjamin Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips, Scott Wilhelm, Qian Zhao