Abstract: There is provided a surface functionalized with cross linking groups adapted to receive antibodies and/or fragments thereof. The surface has an antibody binding biomolecule having a linker region which is covalently crosslinked to functional groups and an antibody binding region. The surface also has a cell interacting biomolecule having a linker region which is covalently crosslinked to functional groups of the surface and a cell interacting region that imparts functional attributes including cell adhesion, spreading, proliferation, differentiation and/or a functional response. The two biomolecules are present in independently controlled concentrations and have similar small molecular weights.

Abstract: The present disclosure relates to anti-fog coatings, coated substrate comprising an anti-fog coating and a process for preparing such coatings. Said process comprising exposing a surface to be coated in a plasma, said plasma produced by exposing a carrier gas comprising an oxidant (e.g. N2/O2, N2/N2O, or air) and a alkylcyclosiloxane (e.g. tetramethylcyclotetrasiloxane) under dielectric barrier discharge (DBD) in Townsend's mode at atmospheric pressure.

Abstract: Transcutaneous intraosseous devices with enhanced antimicrobial properties, as well as their production processes are described. Particularly, the transcutaneous intraosseous device comprises an intraosseous part and a transcutaneous part, wherein at least a surface of said transcutaneous part is provided with at least one adhesion or proliferation agent and at least one antimicrobial agent. For instance, the transcutaneous intraosseous device is intraosseous transcutaneous amputation prosthesis.

Abstract: There is provided a process for manufacturing a carbonaceous anode for an electrolysis cell for the production of aluminium. The process comprises contacting coke particles with a boron-containing solution to obtain boron-impregnated coke particles, mixing the boron-impregnated coke particles with coal tar pitch to form an anode paste, and forming a green anode with the anode paste. A carbonaceous anode for an electrolysis cell for the production of aluminium is also provided, which comprises at least a first fraction of coke particle, a second fraction of coke particles and coal tar pitch, wherein at least the first faction of coke particles comprises boron-impregnated coke particles, the boron-impregnated coke particles being distributed throughout the carbonaceous anode. The carbonaceous anode presents good resistivity towards air and CO2 oxidation, which translates into less dusting of the anode, thus improving its integrity throughout its lifetime.

Abstract: A process for manufacturing magnetic and/or radioactive metal nanoparticles, the process comprising: preparing an electrolyte solution including metal ions and a stabilizer; generating a plasma at an interface of the electrolyte solution at atmospheric pressure; and recovering magnetic and/or radioactive metal nanoparticles. The magnetic metal nanoparticles can comprise magnetoradioactive nanoparticles. The magnetic metal nanoparticles can be used as MRI contrast agents and the magnetoradioactive nanoparticles can also be used as contrast agents and for dual PET/MRI applications. It also relates to a multi-plasma apparatus for synthesizing nanoparticles.

Abstract: The invention relates to an anti-fog coating for a surface of a substrate comprising: a first polymer layer resulting from covalently bonding a polyanhydride polymer to said surface; and a second polymer layer resulting from covalently bonding a polymer selected from the group consisting of polyvinyl alcohol, partially hydrolyzed polyester, polyether and cellulose derivative; said surface having nucleophilic groups. A substrate having an anti-fog coating, as well as a process for preparing said anti-fog coating to the surface of a substrate is also provided.

Abstract: The invention relates to an anti-fog coating, process for producing anti-fog coating at the surface of a substrate such as a thermoplastic polymer and a substrate having anti-fog coating thereon.

Abstract: The invention relates to an anti-fog coating for a surface of a substrate comprising: a first polymer layer resulting from covalently bonding a polyanhydride polymer to said surface; and a second polymer layer resulting from covalently bonding a polymer selected from the group consisting of polyvinyl alcohol, partially hydrolyzed polyester, polyether and cellulose derivative; said surface having nucleophilic groups. A substrate having an anti-fog coating, as well as a process for preparing said anti-fog coating to the surface of a substrate is also provided.

Abstract: In accordance with the present invention, there is provided a novel process for modifying the surface properties of a material that is suitable for contact with animal tissue so as to enhance its hemocompatibility and make it less thrombogenic when in use. This process comprises: Exposing the surface of the material to plasma treatment conditions in order to create reactive groups on said surface; activating a molecule with an activator to produce a reactive molecular species capable of forming convalent bonds with the reactive groups created on the surface of the material to form convalent bonds. The invention further encompasses the materials produced by this process as well as devices, such as vascular prosthesis, that are comprised of these process-modified materials.

Abstract: The use of collagen as a biomedical implant raises safety issues towards viruses and prions. The physicochemical changes and the in vitro and in vivo biocompatibility of collagen treated with heat, and by formic acid (FA), trifluoroacetic acid (TFA), tetrafluoroethanol (TFE) and hexafluoroiso-propanol (HFIP) were investigated. FA and TFA resulted in extensive depurination of nucleic acids while HFIP and TFE did so to a lesser degree. The molecules of FA, and most importantly of TFA, remained within collagen. Although these two acids induced modification in the secondary structure of collagen, resistance to collagenase was not affected and, in vitro, cell growth was not impaired. Severe dehydrothermal treatment, for example 110° C. for 1-3 days under high vacuum, also succeeded in removing completely nucleic acids. Since this treatment also leads to slight cross-linking, it could be advantageously used to eliminate prion and to stabilize gelatin products.