Patents by Inventor Gaetano Giammona

Gaetano Giammona has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190031834
    Abstract: New amphiphilic polymers of formula (I) are described; the process for their preparation and their use as carriers for pharmaceutical drugs is also described.
    Type: Application
    Filed: October 9, 2014
    Publication date: January 31, 2019
    Inventors: Anna Rita BLANCO, Gennara CAVALLARO, Gaetano GIAMMONA, Mariano LICCIARDI, Glovanna PITARRESI, Domenico TROMBETTA
  • Publication number: 20170049896
    Abstract: The present invention relates to a composition comprising hydrogels from functionalized hyaluronic acid derivatives, said hydrogels loaded with exogenous enzymes selected in the group consisting of prolyl endopeptidase (PEP) and endoprotease (EP) intended for the oral treatment of celiac disease. Specifically, this invention concerns a one-pot methodology useful to prepare methacrylic derivatives of hyaluronic acid, through the formation of a specific active group on hydroxyl groups of hyaluronic acid, the subsequent substitution of the inserted active group with ethylenediamine and finally, the reaction with methacrylic anhydride. The obtained methacrylic hyaluronic acid derivatives are used to prepare hydrogels through irradiation and loaded with exogenous enzymes selected in the group consisting of prolyl endopeptidase (PEP) and endoprotease (EP). The ability of prepared hydrogels to allow the enzyme release, as active form in simulated gastrointestinal fluids is proved.
    Type: Application
    Filed: May 6, 2015
    Publication date: February 23, 2017
    Inventors: Giovanna Pitarresi, Fabio Salvatore Palumbo, Gaetano Giammona
  • Patent number: 9410000
    Abstract: In this invention a two steps procedure is described useful to insert functional groups to the hyaluronic acid (HA), through the formation, in organic solvent, of a particular active group on hydroxyl groups of HA and subsequent substitution, on the inserted active group, with a pendant portion containing at least in its terminal portion a nucleophilic functional group, NH2—R. The group inserted by nucleophilic substitution can contain in another its terminal portion a further nucleophilic functional group, in a way to be easily exploitable to further chemical functionalizations, such as an example to obtain the methacrylation of HA functional groups, to obtain photocrosslinkable derivatives. Both direct derivatives of the proposed process and those obtained by the further functionalization can be employed to produce hydrogels.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: August 9, 2016
    Assignee: UNIVERSITA' DEGLI STUDI DI PALERMO
    Inventors: Gaetano Giammona, Fabio Palumbo, Giovanna Pitarresi
  • Patent number: 9283283
    Abstract: The present invention relates to hydrogels based on hyaluronic acid based derivatives, that are more resistant than hyaluronic acid alone towards chemical and enzymatic degradation and are endowed with a mix of chemical and mechanical properties such that they are of optimal use in several surgeries, for instance for injection in bone fractures or cavities and for the production of coatings of prostheses in orthopedic surgery, as fillers in cosmetic and maxillo-facial surgery, as anti-adhesion barrier in the prevention of postoperative adhesions in abdominal and abdominal/pelvic surgery, and in general surgery. These hydrogels can be loaded with several different kinds of compounds having pharmacological and biological activity, that are then released from the hydrogel in the site of intervention.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: March 15, 2016
    Assignees: MERO S.R.L., NOVAGENIT S.R.L.
    Inventors: Gaetano Giammona, Giovanna Pitarresi, Fabio Palumbo, Carlo Luca Romano′, Enzo Meani, Edgardo Cremascoli
  • Publication number: 20150183891
    Abstract: In this invention a two steps procedure is described useful to insert functional groups to the hyaluronic acid (HA), through the formation, in organic solvent, of a particular active group on hydroxyl groups of HA and subsequent substitution, on the inserted active group, with a pendant portion containing at least in its terminal portion a nucleophilic functional group, NH2—R. The group inserted by nucleophilic substitution can contain in another its terminal portion a further nucleophilic functional group, in a way to be easily exploitable to further chemical functionalizations, such as an example to obtain the methacrylation of HA functional groups, to obtain photocrosslinkable derivatives. Both direct derivatives of the proposed process and those obtained by the further functionalization can be employed to produce hydrogels.
    Type: Application
    Filed: November 13, 2014
    Publication date: July 2, 2015
    Applicant: UNIVERSITA' DEGLI STUDI DI PALERMO
    Inventors: Gaetano GIAMMONA, Fabio PALUMBO, Giovanna PITARRESI
  • Patent number: 8858999
    Abstract: In this invention a two steps procedure is described useful to insert functional groups to the hyaluronic acid (HA), through the formation, in organic solvent, of a particular active group on hydroxyl groups of HA and subsequent substitution, on the inserted active group, with a pendant portion containing at least in its terminal portion a nucleophilic functional group, NH2—R. The group inserted by nucleophilic substitution can contain in another its terminal portion a further nucleophilic functional group, in a way to be easily exploitable to further chemical functionalizations, such as an example to obtain the methacrylation of HA functional groups, to obtain photocrosslinkable derivatives. Both direct derivatives of the proposed process and those obtained by the further functionalization can be employed to produce hydrogels.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: October 14, 2014
    Assignee: Universita' Degli Studi di Palermo
    Inventors: Gaetano Giammona, Fabio Palumbo, Giovanna Pitarresi
  • Patent number: 8529935
    Abstract: The present invention relates to hydrogels endowed with antibacterial properties, to be used for injection in damaged bones or in the production of antibacterial coatings of prostheses for implant in the human or animal body, obtained by loading with antibacterial agents hydrogels formed by derivatives of hyaluronic acid; the invention also relates to a kit of parts for producing the antibacterial hydrogels.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: September 10, 2013
    Assignees: Mero S.R.L., Novagenit S.R.L.
    Inventors: Gaetano Giammona, Giovanna Pitarresi, Fabio Palumbo, Carlo Luca Romano, Enzo Meani, Edgardo Cremascoli
  • Publication number: 20130129800
    Abstract: The present invention relates to hydrogels based on hyaluronic acid based derivatives, that are more resistant than hyaluronic acid alone towards chemical and enzymatic degradation and are endowed with a mix of chemical and mechanical properties such that they are of optimal use in several surgeries, for instance for injection in bone fractures or cavities and for the production of coatings of prostheses in orthopedic surgery, as fillers in cosmetic and maxillo-facial surgery, as anti-adhesion barrier in the prevention of postoperative adhesions in abdominal and abdominal/pelvic surgery, and in general surgery. These hydrogels can be loaded with several different kinds of compounds having pharmacological and biological activity, that are then released from the hydrogel in the site of intervention.
    Type: Application
    Filed: July 29, 2011
    Publication date: May 23, 2013
    Applicants: MERO S.R.L., NOVAGENIT S.R.L
    Inventors: Gaetano Giammona, Giovanna Pitarresi, Fabio Palumbo, Carlo Luca Romano', Enzo Meani, Edgardo Cremascoli
  • Publication number: 20110280921
    Abstract: The present invention relates to hydrogels endowed with antibacterial properties, to be used for injection in damaged bones or in the production of antibacterial coatings of prostheses for implant in the human or animal body, obtained by loading with antibacterial agents hydrogels formed by derivatives of hyaluronic acid; the invention also relates to a kit of parts for producing the antibacterial hydrogels.
    Type: Application
    Filed: January 29, 2010
    Publication date: November 17, 2011
    Applicants: NOVAGENIT S.R.L., MERO S.R.L
    Inventors: Gaetano Giammona, Giovanna Pitarresi, Fabio Palumbo, Carlo Luca Romano, Enzo Meani, Edgardo Cremascoli
  • Publication number: 20110236486
    Abstract: A system and method are provided for controlling an internal combustion engine driving a generator/welder or a stand-alone generator. Controlling the engine may include altering the engine speed based upon a detected demand on the generator and/or operating parameters of a welder. For example, the engine speed may be increased based on a detected draw on the generator and/or the operating parameters of the welder. In addition, the engine speed may be automatically decreased to a non-standard idle speed or the engine may be automatically turned off if no demand is detected for a period of time. Additionally, the engine speed may be increased if only frequency-insensitive demands are detected on the generator. Combinations of these and further methods may be executed. Various devices are provided for implementing the above methods.
    Type: Application
    Filed: November 30, 2009
    Publication date: September 29, 2011
    Inventors: Gaetano Giammona, Fabio Palumbo, Giovanna Pitarresi
  • Publication number: 20100247619
    Abstract: This invention relates to nanoparticles consisting of riluzole trapped in lipids, and their use to prepare medicinal products for the treatment of Amyotrophic Lateral Sclerosis and Multiple Sclerosis.
    Type: Application
    Filed: June 26, 2007
    Publication date: September 30, 2010
    Applicants: Consiglio Nazionale Delle Ricerche, Universita' Degli Studi Di Catania, Universita' Degli Studi Di Palermo
    Inventors: Maria Luisa Bondi', Gaetano Giammona, Emanuela Fabiola Craparo, Filippo Drago
  • Publication number: 20090221545
    Abstract: The present invention relates in general to the use of amphiphilic graft-type copolymers of polyaspartamide for the ophthalmic administration of drugs, such as for example steroidal and non-steroidal anti-inflammatory agents, antimicrobial agents such as aminoglycosides, macrolides, cephalosporin, tetracycline, quinolones, penicillin, beta-lactams, anti-glaucoma agents such as prostaglandins, alpha- and beta-blockers, inhibitors of carbonic anhydrase, cannabinoids, antiviral agents, diagnostic agents, anti-angiogenic agents, antioxidants.
    Type: Application
    Filed: March 15, 2007
    Publication date: September 3, 2009
    Applicant: SIFI S.P.A.
    Inventors: Gaetano Giammona, Gennara Cavallaro, Mariano Licciardi, Claudine Civiale, Grazia Maria Paladino, Maria Grazia Mazzone
  • Publication number: 20080292664
    Abstract: Compositions and products based on the chemical crosslinking of hyaluronic acid with a polyfunctional polymer having a protein-like structure, bearing hydrazido pendent groups along the polymeric chain. The polymer is preferably, alpha-beta-polyaspartylhydrazide, a biocompatible macromolecule. The materials obtained after crosslinking, specifically hydrogels, undergo a reduced chemical and enzymatic degradation, unlike the starting hyaluronic acid, and they can be used to prepare systems for applications in the biomedical and pharmaceutical field.
    Type: Application
    Filed: June 23, 2005
    Publication date: November 27, 2008
    Inventors: Gaetano Giammona, Giovanna Pitarresi, Fabio Salvatore Palumbo
  • Publication number: 20070166383
    Abstract: Compositions with pH-dependent modified release are described, consisting of hydrogel matrices containing one or more active ingredients, in which said matrices are suitable for releasing said active ingredients in a prolonged manner in given sites of the body.
    Type: Application
    Filed: February 16, 2005
    Publication date: July 19, 2007
    Applicant: SIGMA-TAU INDUSTIRE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Gaetano Giammona, Delia Mandracchia