Patents by Inventor Gaetano Montelione

Gaetano Montelione has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transcript optimized expression enhancement for high-level production of proteins and protein domains
    Patent number: 10385350
    Abstract: The present invention relates to a system for high-level production of recombinant proteins and protein domains.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: August 20, 2019
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Thomas B. Acton, Stephen Anderson, Yuanpeng Janet Huang, Gaetano Montelione
  • TRANSCRIPT OPTIMIZED EXPRESSION ENHANCEMENT FOR HIGH-LEVEL PRODUCTION OF PROTEINS AND PROTEIN DOMAINS
    Publication number: 20160201068
    Abstract: The present invention relates to a system for high-level production of recombinant proteins and protein domains.
    Type: Application
    Filed: October 14, 2015
    Publication date: July 14, 2016
    Inventors: Thomas B. Acton, Stephen Anderson, Yuanpeng Janet Huang, Gaetano Montelione
  • TRANSCRIPT OPTIMIZED EXPRESSION ENHANCEMENT FOR HIGH-LEVEL PRODUCTION OF PROTEINS AND PROTEIN DOMAINS
    Publication number: 20140273091
    Abstract: The present invention relates to a system for high-level production of recombinant proteins and protein domains.
    Type: Application
    Filed: November 13, 2012
    Publication date: September 18, 2014
    Inventors: Thomas B. Acton, Stephen Anderson, Yuanpeng Janet Huang, Gaetano Montelione
  • Influenza A virus vaccines and inhibitors
    Patent number: 8796008
    Abstract: The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF 30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: August 5, 2014
    Assignees: Board of Regents, The University of Texas System, Rutgers, The State University of New Jersey
    Inventors: Gaetano Montelione, Kalyan Das, Edward Arnold, Li-Chung Ma, Rong Xiao, Rei-Lin Kuo, Robert M. Krug, Karen Y. Twu
  • Influenza A Virus Vaccines and Inhibitors
    Publication number: 20140044745
    Abstract: The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
    Type: Application
    Filed: May 31, 2013
    Publication date: February 13, 2014
    Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Gaetano Montelione, Kalyan Das, Edward Arnold, Li-Chung Ma, Rong Xiao, Robert M. Krug, Karen Y. Twu, Rei-Lin Kuo
  • Influenza A virus vaccines and inhibitors
    Patent number: 8455621
    Abstract: The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: June 4, 2013
    Assignees: Rutgers, The State University of New Jersery, Board of Regents, The University of Texas System
    Inventors: Robert M. Krug, Karen Y. Twu, Rei-Lin Kuo, Gaetano Montelione, Edward Arnold, Kalyan Das, LiChung Ma, Rong Xiao
  • Influenza A Virus Vaccines and Inhibitors
    Publication number: 20100247569
    Abstract: The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
    Type: Application
    Filed: February 17, 2010
    Publication date: September 30, 2010
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Gaetano Montelione, Kalyan Das, Edward Arnold, LiChung Ma, Rong Xiao, Robert M. Krug, Karen Y. Twu, Rei-Lin Kuo
  • Influenza A virus vaccines and inhibitors
    Patent number: 7709190
    Abstract: The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
    Type: Grant
    Filed: December 2, 2006
    Date of Patent: May 4, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Gaetano Montelione, Kalyan Das, Edward Arnold, LiChung Ma, Rong Xiao, Robert M. Krug, Karen Y. Twu, Rei-Lin Kuo
  • INFLUENZA A VIRUS VACCINES AND INHIBITORS
    Publication number: 20080108050
    Abstract: The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
    Type: Application
    Filed: December 2, 2006
    Publication date: May 8, 2008
    Inventors: Gaetano Montelione, Kalyan Das, Edward Arnold, LiChung Ma, Rong Xiao, Robert M. Krug, Karen Y. Twu, Rei-Lin Kuo
  • Linking gene sequence to gene function by three dimensional (3D) protein structure determination
    Publication number: 20050233357
    Abstract: The present invention provides a structure-functional analysis engine for the high-throughput determination of the biochemical function of proteins or protein domains of unknown function. The present invention uses bioinformatics, molecular biology and nuclear magnetic resonance tools for the rapid and automated determination of the three-dimensional structures of proteins and protein domains.
    Type: Application
    Filed: February 25, 2005
    Publication date: October 20, 2005
    Inventors: Stephen Anderson, Gaetano Montelione
  • LINKING GENE SEQUENCE TO GENE FUNCTION BY THREE DIMESIONAL (3D) PROTEIN STRUCTURE DETERMINATION
    Publication number: 20010016314
    Abstract: The present invention provides a structure-functional analysis engine for the high-throughput determination of the biochemical function of proteins or protein domains of unknown function. The present invention uses bioinformatics, molecular biology and nuclear magnetic resonance tools for the rapid and automated determination of the three-dimensional structures of proteins and protein domains.
    Type: Application
    Filed: October 29, 1998
    Publication date: August 23, 2001
    Inventors: STEPHEN ANDERSON, GAETANO MONTELIONE