Patents by Inventor Gaetano Palladino

Gaetano Palladino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the conversion of daunorubicin into doxorubicin
    Patent number: 5008380
    Abstract: An improved process for the preparation of doxorubicin, by means of hydrolysis of a doxorubicin ester of a dicarboxylic acid, in acid medium.
    Type: Grant
    Filed: November 9, 1988
    Date of Patent: April 16, 1991
    Assignee: Sicor Societa 'Italiana Corticosteroidi S.p.A.
    Inventors: Gaetano Palladino, Peter MacDonald, Ettore Bigatti
  • 16,17-Pyrazolino- and 16,17-isopyrazolino-1,4-pregnadiene derivatives
    Patent number: 4232013
    Abstract: New 16,17-pyrazolino- and 16,17-isopyrazolino-1,4-pregnadiene-derivatives have been prepared, useful as antiinflammatory agents on topical and/or systemic administration. An analogy process for the preparation of 16,17-pyrazolino-1,4-pregnadiene derivatives and the quite surprising conversion of the latter ones to 16,17-isopyrazolino-1,4-pregnadiene derivatives are also disclosed. The results of pharmacological comparative trails of some new products of the present invention v. fluocinolone acetonide are reported.
    Type: Grant
    Filed: November 30, 1978
    Date of Patent: November 4, 1980
    Assignee: Lark S.p.A.
    Inventors: Gaetano Palladino, Mario Micciarelli
  • Steroids and process for preparing the same
    Patent number: 4226862
    Abstract: Novel steroids are described together with processes of making them and pharmaceutical compositions containing them. The steroids have pharmaceutical activity, especially anti-inflammatory activity. They are all 2-Bromo-6.beta.-fluoro-pregna-1,4-diene-3,20-diones.
    Type: Grant
    Filed: February 26, 1975
    Date of Patent: October 7, 1980
    Assignee: Pierrel S.p.A.
    Inventors: Mario Riva, Gaetano Palladino, Lucian Toscano
  • 2-Bromo-6.beta.-fluoro-3-keto-.DELTA..sup.1,4 -steroids of the pregnane series
    Patent number: 4189440
    Abstract: Pregnane series steroids are disclosed having good anti-inflammatory and anti-rheumatoid arthritic activity with a decreased degree of side effects, e.g., weight loss and sodium retention. The compounds have the formula ##STR1## where X is a keto- or .beta.-hydroxyl group or chlorine, Y is fluorine or chlorine, Z is hydrogen, .alpha.-hydroxyl, .alpha.-methyl or .beta.-methyl, R' is hydrogen or a 2 to 8 carbon acyl group and R is hydrogen, a 2 to 8 carbon acyl group from mono- or di-carboxylic organic acids, a metasulfobenzoic acid residue or phosphoric acid residue.When R' is hydrogen, and Z is .alpha.-hydroxyl the corresponding 16.alpha., 17.alpha.-acetonides and 16.alpha.-acyl derivatives with organic carboxylic acids having from 2 to 8 carbon atoms were prepared.
    Type: Grant
    Filed: November 24, 1975
    Date of Patent: February 19, 1980
    Inventor: Gaetano Palladino
  • 16-Alpha-methyl-17 alpha-bromo-1,4-pregnadiene-21-ol-3,20-dione-derivatives
    Patent number: 4031080
    Abstract: There is disclosed 16 alpha-methyl-17 alpha-bromo-1,4-pregnadiene-21-ol-3,20-dione-type compounds of the formula ##STR1## where R is hydrogen or acyl; X is hydrogen, bromine, or fluorine; Y is hydrogen or oxygen; and Z is hydrogen or .alpha.- or .beta.-oriented fluorine. The compounds are useful in treating rheumatoid arthritis and related inflammatory disorders as well as allergic diseases.
    Type: Grant
    Filed: January 29, 1976
    Date of Patent: June 21, 1977
    Assignee: Lark S.p.A.
    Inventor: Gaetano Palladino